Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Padmanava Pradhan"'
Publikováno v:
Chemical Communications. 58:1744-1747
Facile synthesis of adenosine and 2′-deoxyadenosine 8-carboxaldehydes provides a segue to diversely C8-functionalized adenine nucleoside analogues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875c7718b9d2d68231eb3d5528603cd4
https://doi.org/10.1039/d1cc06686b
https://doi.org/10.1039/d1cc06686b
Publikováno v:
The Journal of Organic Chemistry. 87:18-39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c78e28cb76ab3ff48ae51c0e236aa22
https://doi.org/10.1021/acs.joc.1c01587
https://doi.org/10.1021/acs.joc.1c01587
Autor:
Dellamol, Sebastian, Sakilam, Satishkumar, Padmanava, Pradhan, Lijia, Yang, Mahesh K, Lakshman
Publikováno v:
The Journal of organic chemistry. 87(1)
Among the C6-halo purine ribonucleosides, the readily accessible 6-chloro derivative has been known to undergo slow S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::844eaa7543c60769e6c0f133ac1c9adb
https://pubmed.ncbi.nlm.nih.gov/34905365
https://pubmed.ncbi.nlm.nih.gov/34905365
Publikováno v:
Chemistry
Mitomycin C, (MC), an antitumor drug, is a DNA alkylating agent currently used in the clinics. Inert in its native form, MC is reduced to reactive mitosenes, which undergo nucleophilic attack by guanine or adenine bases in DNA to form monoadducts as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40cdae7bae4149535cf4f0240609e3e6
https://pubmed.ncbi.nlm.nih.gov/34319608
https://pubmed.ncbi.nlm.nih.gov/34319608
Autor:
Jessica D. Hess, Mahesh K. Lakshman, Padmanava Pradhan, Robert Snoeck, Renato J. Aguilera, Dominique Schols, Tashrique A. Khandaker, Graciela Andrei
Publikováno v:
European Journal of Organic Chemistry
1,4‐Triazolyl combretacoumarins have been prepared by linking the trimethoxyarene unit of combretastatin A4 with coumarins, via a 1,2,3‐triazole. For this, 4‐azidocoumarins were accessed by a sequential two‐step, one‐pot reaction of 4‐hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397abe675193e8985ea2b9d9f9d7d589
https://doi.org/10.1002/ejoc.201900569
https://doi.org/10.1002/ejoc.201900569
Autor:
Manuel M. Paz, Elise Champeil, Maggie Zheng, William Aguilar, Sergey Tsukanov, Shu-Yuan Cheng, Padmanava Pradhan, Owen Zacarias
Publikováno v:
Chemical Research in Toxicology. 31:762-771
Mitomycin C (MC) is an anticancer agent that alkylates DNA to form monoadducts and interstrand cross-links. Decarbamoylmitomycin C (DMC) is an analogue of MC lacking the carbamate on C10. The major DNA adducts isolated from treatment of culture cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd11600dae178d963ac44704195ec93
https://doi.org/10.1021/acs.chemrestox.8b00102
https://doi.org/10.1021/acs.chemrestox.8b00102
Autor:
Siva Subrahmanyam Relangi, Narender Pottabathini, Somesh Sharma, Magdalena R. Andrzejewska, Prasanna K. Vuram, Kirill A. Korvinson, Mahesh K. Lakshman, Venkateshwarlu Gurram, Raju Doddipalla, Lothar Stahl, Michelle C. Neary, Padmanava Pradhan
Publikováno v:
Advanced Synthesis & Catalysis. 360:2503-2510
A facile and broadly applicable method for the regiospecific N-arylation of benzotriazoles is reported. Copper-mediated reactions of diverse 1-hydroxy-1H-benzotriazoles with aryl boronic acids lead to 1-aryl-1H-benzotriazole 3-oxides. A N1-OH → N3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c19c69e06bf2ba7da823ff8c9b58066
https://doi.org/10.1002/adsc.201701611
https://doi.org/10.1002/adsc.201701611
Publikováno v:
Journal of Agricultural and Food Chemistry. 66:424-431
The mechanism of the reaction of dichlorvos through hydrolysis reactions and through the reaction with polysulfide (Sn2–) and thiophenolate (PhS–) was investigated by proton nuclear magnetic resonance (1H NMR). The study confirmed product identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711e6e5bd84702631fecdce36cedb355
https://doi.org/10.1021/acs.jafc.7b04749
https://doi.org/10.1021/acs.jafc.7b04749
Autor:
Padmanava Pradhan, Dellamol Sebastian, Sakilam Satishkumar, Mahesh K. Lakshman, Narender Pottabathini, Prasanna K. Vuram, Suresh Poudapally, Venkateshwarlu Gurram, Lijia Yang
Publikováno v:
ChemCatChem. 9:4058-4069
In this work we have assessed reactions of N6-([1,1′-biaryl]-2-yl)adenine nucleosides with Pd(OAc)2 and PhI(OAc)2, via a PdII/PdIV redox cycle. The substrates are readily obtained by Pd/Xantphos-catalyzed reaction of adenine nucleosides with 2-brom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::932e414a2fc8ed4fab20dcad646e7276
https://doi.org/10.1002/cctc.201700918
https://doi.org/10.1002/cctc.201700918
Autor:
Maggie Zheng, Seokjin Hwang, Timothy Snyder, Jake Aquilina, Gloria Proni, Manuel M. Paz, Padmanava Pradhan, Shu-Yuan Cheng, Elise Champeil
Publikováno v:
Bioorg Chem
Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad4431b02bb536644de398ab3feb14
https://europepmc.org/articles/PMC6936608/
https://europepmc.org/articles/PMC6936608/
