Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Padma K Narayanan"'
Autor:
Marjory B Brooks, James R Turk, Abraham Guerrero, Padma K Narayanan, John P Nolan, Elizabeth G Besteman, Dennis W Wilson, Roberta A Thomas, Cindy E Fishman, Karol L Thompson, Heidrun Ellinger-Ziegelbauer, Jennifer B Pierson, April Paulman, Alan Y Chiang, Albert E Schultze
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Externí odkaz:
https://doaj.org/article/d1a2148f4656495f9cebe693e28738c6
Autor:
Madeline M. Fort, Nancy E. Everds, Mai Phuong Nguyen, Linda O. Narhi, Darcey Clark, Yan Bin Yu, Padma K. Narayanan, Nianyu Li, Yao Zhuang, Riki Stevenson, Kannan Gunasekaran, Jeanine L. Bussiere, Ling Liu, Kei Kim, Frederick W. Jacobsen
Publikováno v:
Journal of Biological Chemistry. 292:1876-1883
The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability to interact with Fcγ receptors. The engineering and stability and pharmacokinetic assessments of the SEFL scaffold is des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a204efe86df5cc245649bcfd88de2ae9
https://doi.org/10.1074/jbc.m116.748707
https://doi.org/10.1074/jbc.m116.748707
Publikováno v:
Current protocols in toxicology. 80(1)
Macrophages are innate immune cells that play important roles in various physiological and pathological processes. Evaluation of pro-inflammatory effects of drugs on macrophages has become commonplace in preclinical drug development prior to human cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1684fa956a85bba94302f2f5dae300ee
https://pubmed.ncbi.nlm.nih.gov/30982234
https://pubmed.ncbi.nlm.nih.gov/30982234
Autor:
Nianyu Li, Padma K. Narayanan
Publikováno v:
Current protocols in toxicology. 79(1)
Phagocytosis of platelets by monocytes and macrophages is a primary mechanism of platelet clearance in vivo and has been increasingly implicated in playing an important role in thrombocytopenia mediated by monoclonal antibodies intended for therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76966c832763885aab395f6c0e958cb
https://pubmed.ncbi.nlm.nih.gov/30673165
https://pubmed.ncbi.nlm.nih.gov/30673165
Autor:
Samuel A Stoner, Abraham Guerrero, Padma K. Narayanan, James R. Turk, Erika Duggan, John P. Nolan, Danilo Condello
Publikováno v:
Cytometry Part A. 89:196-206
Extracellular vesicles (EVs) are attracting attention as vehicles for inter-cellular signaling that may have value as diagnostic or therapeutic targets. EVs are released by many cell types and by different mechanisms, resulting in phenotypic heteroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9739ca83b4c94ebe5ae77ac884409401
https://doi.org/10.1002/cyto.a.22787
https://doi.org/10.1002/cyto.a.22787
Autor:
John P. Nolan, Jennifer B. Pierson, Marjory B. Brooks, James R. Turk, Cindy E. Fishman, Dennis W Wilson, Heidrun Ellinger-Ziegelbauer, Albert E. Schultze, April Paulman, Karol L. Thompson, Padma K. Narayanan, Abraham Guerrero, Elizabeth G. Besteman, Roberta A. Thomas, Alan Y. Chiang
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
PLoS ONE
PLoS ONE
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f0f7b6e886f341ea0b64779bd07d26
http://europepmc.org/articles/PMC5233421?pdf=render
http://europepmc.org/articles/PMC5233421?pdf=render
Autor:
Ruth Lightfoot-Dunn, Roderick A. Capaldi, Padma K. Narayanan, Cynthia A. Afshari, Nianyu Li, J. Paul Robinson, Yudong D. He, Hisham K. Hamadeh, C. Elisa Oquendo
Publikováno v:
Toxicological Sciences. 142:261-273
Mitochondrial perturbation has been recognized as a contributing factor to various drug-induced organ toxicities. To address this issue, we developed a high-throughput flow cytometry-based mitochondrial signaling assay to systematically investigate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca9589f884f37577676d709a18c5e56
https://doi.org/10.1093/toxsci/kfu176
https://doi.org/10.1093/toxsci/kfu176
Autor:
Carla Forte, Darcey Clark, Padma K. Narayanan, Daniel T. Mytych, M. Benjamin Hock, Faith Shiota
Publikováno v:
Journal of Immunological Methods. 392:29-37
Immunoglobulin E (IgE) is the least abundant immunoglobulin in serum. However, development of an IgE immune response can induce IgE receptor-expressing cells to carry out potent effector functions. A reliable antigen-specific IgE biomarker method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cac628124ab6c41b07fa43916ef38e
https://doi.org/10.1016/j.jim.2013.03.007
https://doi.org/10.1016/j.jim.2013.03.007
Autor:
Ching He, Nancy Doyle, Erin Stevens, Padma K. Narayanan, Remi Jawando, Cen Xu, Nianyu Li, Madeline M. Fort, Kevin Salyers, Florence Poitout-Belissent, Riki Stevenson, Mai Phuong Nguyen, Katherine Sprugel, Vibha Jawa, Nancy E. Everds, Keith Bailey, Sam M Tran, Jacquelin Jolette
Publikováno v:
Toxicologic Pathology. 41:951-969
Cynomolgus monkeys dosed with a therapeutic monoclonal antibody (mAbY.1) at ≥50 mg/kg had unexpected acute thrombocytopenia (nadir ∼3,000 platelets/µl), sometimes with decreases in red cell mass. Increased activated macrophages, mitotic figures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705a5085d5ece89e6d49152525d560d7
https://doi.org/10.1177/0192623312474727
https://doi.org/10.1177/0192623312474727
Publikováno v:
Toxicologic Pathology. 40:107-112
Regulatory T cells (Tregs) are a rare subset of lymphocytes that inhibit the activation and effector functions of T cells and are important regulators of immune responses. Although Tregs are well characterized in humans and rodents, little is known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c7a2d42d978ff0722f54864683360b
https://doi.org/10.1177/0192623311425056
https://doi.org/10.1177/0192623311425056