Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Padma Akkapeddi"'
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Autor:
Shohei Koide, Benjamin G. Neel, Injin Bang, Padma Akkapeddi, James Hayman, Akiko Koide, Kiyomi Y. Araki, Lorenzo Maso, Takamitsu Hattori
Intracellular oncoproteins can be inhibited with targeted therapy, but responses are not durable. Immune therapies can be curative, but most oncogene-driven tumors are unresponsive to these agents. Fragments of intracellular oncoproteins can act as n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e832e5573620213e2f0cc7d655291b
https://doi.org/10.1158/2159-8290.c.6549729.v1
https://doi.org/10.1158/2159-8290.c.6549729.v1
Autor:
Shohei Koide, Benjamin G. Neel, Injin Bang, Padma Akkapeddi, James Hayman, Akiko Koide, Kiyomi Y. Araki, Lorenzo Maso, Takamitsu Hattori
Supplementary Figure S1 shows size exclusion chromatography profiles of products of the refolding reactions for p/MHCs utilized in this study. Supplementary Figure S2 shows binding properties of antibodies to sotorasib-KRAS(G12C) peptide conjugates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dd38cd406cacd8bb0922190f85887e
https://doi.org/10.1158/2159-8290.22541703.v1
https://doi.org/10.1158/2159-8290.22541703.v1
Autor:
Takamitsu Hattori, Lorenzo Maso, Kiyomi Y. Araki, Akiko Koide, James Hayman, Padma Akkapeddi, Injin Bang, Benjamin G. Neel, Shohei Koide
Publikováno v:
Cancer discovery.
Intracellular oncoproteins can be inhibited with targeted therapy, but responses are not durable. Immune therapies can be curative, but most oncogene-driven tumors are unresponsive to these agents. Fragments of intracellular oncoproteins can act as n
Autor:
Takamitsu Hattori, Padma Akkapeddi, Imran Khan, Akiko Koide, Eliezra Glasser, Gayatri Ketavarapu, Michael Whaby, Mariyam Zuberi, Kai Wen Teng, Julia Lefler, Lorenzo Maso, Injin Bang, Michael C. Ostrowski, John P. O’Bryan, Shohei Koide
Publikováno v:
Molecular Cancer Research. 21:B013-B013
The G12D mutation is among the most common KRAS mutations associated with cancer, in particular pancreatic cancer. Here, we have developed monobodies, small synthetic binding proteins, that are highly selective to KRAS(G12D) over KRAS(wild type) and
Autor:
Lorenzo Maso, Takamitsu Hattori, Kiyomi Araki, Akiko Koide, Epsa Rajak, James Hayman, Padma Akkapeddi, Injin Bang, Benjamin G. Neel, Shohei Koide
Publikováno v:
Molecular Cancer Research. 21:B020-B020
Covalent inhibitors against KRAS(G12C) represent major breakthroughs in the effort to directly and selectively target oncogenic RAS mutants. However, similar to other targeted therapies, they lack durability. Immune therapy can be curative, and fragm
Publikováno v:
RSC Medicinal Chemistry
Despite increased investment and technological advancement, new drug approvals have not proportionally increased. Low drug approval rates, particularly for new targets, are linked to insufficient target validation at early stages. Thus, there remains
Autor:
Catherine Diefenbach, Huilin J Li, Kai Wen Teng, Marie I. Samanovic, Jessica Caro, Sara A Thannickal, Mark J. Mulligan, Larizbeth A. Romero, Akiko Koide, Francesca-Zhoufan Li, Chan Wang, Padma Akkapeddi, Takamitsu Hattori, Kenneth A. Stapleford, Alexis D. Corrado, Shohei Koide, Tatyana Panchenko
Publikováno v:
bioRxiv
SUMMARYAntibody responses serve as the primary protection against SARS-CoV-2 infection through neutralization of viral entry into cells. We have developed a two-dimensional multiplex bead binding assay (2D-MBBA) that quantifies multiple antibody isot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b82493c3a5118ffb897478ca68691f
https://doi.org/10.1101/2021.08.03.454782
https://doi.org/10.1101/2021.08.03.454782
Autor:
Rita Fragoso, Mattia Matasci, Julie A. Hixon, Gonçalo J. L. Bernardes, Scott K. Durum, Padma Akkapeddi, João T. Barata, Francisco Corzana, Mariana L. Oliveira, Dario Neri, Ana Sofia Ramalho, Tânia Carvalho, Andreas Gloger
Publikováno v:
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Leukemia
Leukemia, 33 (9)
instname
Leukemia
Leukemia, 33 (9)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer for which treatment options often result in incomplete therapeutic efficacy and long-term side-effects. Interleukin 7 (IL-7) and its receptor IL-7Rα promote T-ALL deve