Výsledky vyhledávání - "Padhma Ranganathan"

Supplementary Figures 1-5, Table 1 from Par-4 Binds to Topoisomerase 1 and Attenuates Its DNA Relaxation Activity

Autor: Vivek M. Rangnekar, Yves Pommier, Ravshan Burikhanov, Padhma Ranganathan, Thomas S. Dexheimer, Shirley Qiu, Anindya Goswami

Supplementary Figures 1-5, Table 1 from Par-4 Binds to Topoisomerase 1 and Attenuates Its DNA Relaxation Activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9f0c52dc85f05f7c2355d549e63429
https://doi.org/10.1158/0008-5472.22377173.v1

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Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function

Autor: Emily R. Albright, Kylee Morrison, Padhma Ranganathan, Dominique M. Carter, Masaki Nishikiori, Jeong-Hee Lee, Mark D. Slayton, Paul Ahlquist, Scott S. Terhune, Robert F. Kalejta

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(14)

Replication-dependent (RD) histones are deposited onto human cytomegalovirus (HCMV) genomes at the start of infection. We examined how HCMV affects the de novo production of RD histones and found that viral infection blocked the accumulation of RD hi

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https://pubmed.ncbi.nlm.nih.gov/35344424

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Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples

Autor: Padhma Ranganathan, Robert F. Kalejta, Paul A. Clark, M. S. Salamat, John S. Kuo

Publikováno v: Journal of Virology. 86:854-864

Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and lethal brain

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https://doi.org/10.1128/jvi.06097-11

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Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity

Autor: Padhma Ranganathan, Ravshan Burikhanov, Shirley Qiu, Yves Pommier, Thomas S. Dexheimer, Anindya Goswami, Vivek M. Rangnekar

Publikováno v: Cancer research. 68(15)

The regulation of DNA relaxation by topoisomerase 1 (TOP1) is essential for DNA replication, transcription, and recombination events. TOP1 activity is elevated in cancer cells, yet the regulatory mechanism restraining its activity is not understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef76b0b53161c49128267d4a9ba8f5f
https://pubmed.ncbi.nlm.nih.gov/18676842

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Regulation of Par-4 by oncogenic Ras

Autor: Krishna Murthi, Vasudevan, Padhma, Ranganathan, Vivek M, Rangnekar

Publikováno v: Methods in enzymology. 407

Oncogenic Ras causes down-regulation of the proapoptotic tumor suppressor gene Par-4. Replenishment of the basal levels of Par-4 results in inhibition of Ras-inducible cellular transformation. Moreover, overexpression of Par-4 (twofold to fourfold ov

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https://pubmed.ncbi.nlm.nih.gov/16757343

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The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target

Autor: Padhma Ranganathan, Anindya Goswami, Vivek M. Rangnekar

Publikováno v: Cancer research. 66(6)

Activation of the phosphoinositide 3-kinase (PI3K)/Akt cell survival pathway in many cancers makes it an appealing target for therapeutic development. However, because this pathway also has an important role in the survival of normal cells, tactics t

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https://pubmed.ncbi.nlm.nih.gov/16540633

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Regulation of Par‐4 by Oncogenic Ras

Autor: Padhma Ranganathan, Krishna Murthi Vasudevan, Vivek M. Rangnekar

Oncogenic Ras causes down‐regulation of the proapoptotic tumor suppressor gene Par‐4. Replenishment of the basal levels of Par‐4 results in inhibition of Ras‐inducible cellular transformation. Moreover, overexpression of Par‐4 (twofold to f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ddecf8c644564ec1cec83b585277ee7
https://doi.org/10.1016/s0076-6879(05)07035-7

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Regulation of cancer cell survival by Par-4

Autor: Padhma Ranganathan, Vivek M. Rangnekar

Publikováno v: Annals of the New York Academy of Sciences. 1059

Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00a091ad60455bc2217d6ec80a4c60e
https://pubmed.ncbi.nlm.nih.gov/16382046

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Exploiting the TSA connections to overcome apoptosis-resistance

Autor: Padhma Ranganathan, Vivek M. Rangnekar

Publikováno v: Cancer biologytherapy. 4(4)

Commentary to:Trichostatin A (TSA) Sensitizes the Human Prostatic Cancer Cell Line DU145 to Death Receptor Ligands TreatmentAgshin F. Taghiyev, Natalya V. Guseva, Mary T. Sturm, Oskar W. Rokhlin and Michael B. Cohen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e60e0f9c06b0d66b1c20dea68397a
https://pubmed.ncbi.nlm.nih.gov/15846101

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