Sex-specific resilience of neocortex to food restriction.

Autor: Padamsey Z; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom., Katsanevaki D; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, United Kingdom., Maeso P; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom., Rizzi M; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom., Osterweil EE; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, United Kingdom.; Rosamund Stone Zander Translational Neuroscience Center, F.M. Kirby Center, Boston Children's Hospital, Harvard Medical School, Boston, United States., Rochefort NL; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, United Kingdom.

Publikováno v: ELife [Elife] 2024 Jul 08; Vol. 12. Date of Electronic Publication: 2024 Jul 08.

Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber

Autor: Vasquez-Lopez, S, Turcotte, R, Koren, V, Ploschner, M, Padamsey, Z, Booth, M, Čižmár, T, Emptage, N

Publikováno v: Light, Science & Applications
Light: Science & Applications, Vol 7, Iss 1, Pp 1-6 (2018)
Vasquez-Lopez, S A, Turcotte, R, Koren, V, Plöschner, M, Padamsey, Z, Booth, M J, Čižmár, T & Emptage, N J 2018, ' Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber ', Light: Science and Applications, vol. 7, 110 . https://doi.org/10.1038/s41377-018-0111-0

Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system 1,2,3,4. Advances in wavefront-shaping method

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Homeostatic presynaptic plasticity is specifically regulated by P/Q-type Ca2+ channels at mammalian hippocampal synapses

Autor: Jeans, A, van Heusden, F, Al-Mubarak, B, Padamsey, Z, Emptage, N

Publikováno v: Cell Reports, Vol 21, Iss 2, Pp 341-350 (2017)
Jeans, A F, van Heusden, F C, Al-Mubarak, B, Padamsey, Z & Emptage, N J 2017, ' Homeostatic Presynaptic Plasticity Is Specifically Regulated by P/Q-type Ca2+ Channels at Mammalian Hippocampal Synapses ', Cell Reports, vol. 21, no. 2, pp. 341-350 . https://doi.org/10.1016/j.celrep.2017.09.061

Summary: Voltage-dependent Ca2+ channels (VGCC) represent the principal source of Ca2+ ions driving evoked neurotransmitter release at presynaptic boutons. In mammals, presynaptic Ca2+ influx is mediated mainly via P/Q-type and N-type VGCC, which dif

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Neocortex saves energy by reducing coding precision during food scarcity.

Autor: Padamsey Z; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address: zahid.padamsey@ed.ac.uk., Katsanevaki D; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK., Dupuy N; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK., Rochefort NL; Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address: n.rochefort@ed.ac.uk.

Publikováno v: Neuron [Neuron] 2022 Jan 19; Vol. 110 (2), pp. 280-296.e10. Date of Electronic Publication: 2021 Nov 05.

Activity-dependent exocytosis of lysosomes regulates structural plasticity of dendritic spines

Autor: Padamsey, Z, McGuinness, L, Bardo, S, Reinhart, M, Tong, R, Hedegaard, A, Hart, M, Emptage, N

Publikováno v: Neuron. 93(1)

Lysosomes have traditionally been viewed as degradative organelles, though a growing body of evidence suggests that they can function as Ca2+ stores. Here, we examined the function of these stores in hippocampal pyramidal neurons. We found that back-

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