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Optical Quantal Analysis Using Ca2+ Indicators: A Robust Method for Assessing Transmitter Release Probability at Excitatory Synapses by Imaging Single Glutamate Release Events

Autor: Padamsey, Z, Tong, R, Emptage, N

Publikováno v: Frontiers in Synaptic Neuroscience
Frontiers in Synaptic Neuroscience, Vol 11 (2019)

Despite evidence that presynaptic efficacy and plasticity influence circuit function and behavior in vivo, studies of presynaptic function remain challenging owing to the difficulty of assessing transmitter release in intact tissue. Electrophysiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e27c7e2187aa7867025b6f85023aa2cb
http://europepmc.org/articles/PMC6409341

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Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber

Autor: Vasquez-Lopez, S, Turcotte, R, Koren, V, Ploschner, M, Padamsey, Z, Booth, M, Čižmár, T, Emptage, N

Publikováno v: Light, Science & Applications
Light: Science & Applications, Vol 7, Iss 1, Pp 1-6 (2018)
Vasquez-Lopez, S A, Turcotte, R, Koren, V, Plöschner, M, Padamsey, Z, Booth, M J, Čižmár, T & Emptage, N J 2018, ' Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber ', Light: Science and Applications, vol. 7, 110 . https://doi.org/10.1038/s41377-018-0111-0

Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system 1,2,3,4. Advances in wavefront-shaping method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::723103814f7275884f43543d9afcfbb6
https://ora.ox.ac.uk/objects/uuid:2795ae3f-48b3-4f12-a78c-7072d12f8db1

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Homeostatic presynaptic plasticity is specifically regulated by P/Q-type Ca2+ channels at mammalian hippocampal synapses

Autor: Jeans, A, van Heusden, F, Al-Mubarak, B, Padamsey, Z, Emptage, N

Publikováno v: Cell Reports, Vol 21, Iss 2, Pp 341-350 (2017)
Jeans, A F, van Heusden, F C, Al-Mubarak, B, Padamsey, Z & Emptage, N J 2017, ' Homeostatic Presynaptic Plasticity Is Specifically Regulated by P/Q-type Ca2+ Channels at Mammalian Hippocampal Synapses ', Cell Reports, vol. 21, no. 2, pp. 341-350 . https://doi.org/10.1016/j.celrep.2017.09.061

Summary: Voltage-dependent Ca2+ channels (VGCC) represent the principal source of Ca2+ ions driving evoked neurotransmitter release at presynaptic boutons. In mammals, presynaptic Ca2+ influx is mediated mainly via P/Q-type and N-type VGCC, which dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8fe049c651be3301c0d718f97c9b8db3
http://ora.ox.ac.uk/objects/uuid:

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Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity

Autor: Costa, R, Padamsey, Z, D’Amour, J, Emptage, N, Froemke, R, Vogels, T

Publikováno v: Costa, R P, Padamsey, Z, D'Amour, J A, Emptage, N J, Froemke, R C & Vogels, T P 2017, ' Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity ', Neuron, vol. 96, no. 1, pp. 177-189.e7 . https://doi.org/10.1016/j.neuron.2017.09.021
Neuron

Summary Long-term modifications of neuronal connections are critical for reliable memory storage in the brain. However, their locus of expression—pre- or postsynaptic—is highly variable. Here we introduce a theoretical framework in which long-ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed92060960b402430bb257756b34dadf
https://www.pure.ed.ac.uk/ws/files/138856750/Padamsey_Z_Synaptic_Transmission...pdf

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Mechanisms of long-term presynaptic plasticity at Schaffer-collateral synapses

Autor: Padamsey, Z

Synaptic plasticity is thought to be integral to learning and memory. The two most common forms of plasticity are long-term potentiation (LTP) and long-term depression (LTD), both of which can be supported either by presynaptic changes in transmitter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::d76aaef494fdd2b1061980e5db3a7082
https://ora.ox.ac.uk/objects/uuid:02614738-e51e-41e6-9f45-b07c797ed14a

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Activity-dependent exocytosis of lysosomes regulates structural plasticity of dendritic spines

Autor: Padamsey, Z, McGuinness, L, Bardo, S, Reinhart, M, Tong, R, Hedegaard, A, Hart, M, Emptage, N

Publikováno v: Neuron. 93(1)

Lysosomes have traditionally been viewed as degradative organelles, though a growing body of evidence suggests that they can function as Ca2+ stores. Here, we examined the function of these stores in hippocampal pyramidal neurons. We found that back-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cbba427ffffd52b378872c64957ee8ff
http://ora.ox.ac.uk/objects/uuid:

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