Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Paco S. Herson"'
Autor:
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson
Publikováno v:
Frontiers in Stroke, Vol 3 (2024)
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and m
Externí odkaz:
https://doaj.org/article/72552ed10298439ca0b525e2e9a0ba77
Autor:
Alexander Keister, Arianna Carfora, Mayur S. Patel, Amanda S. Zakeri, Lillian Mannix, Debra G. Wheeler, Paco S. Herson, Shahid M. Nimjee
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 4, Iss 4 (2024)
Preclinical models of large‐vessel occlusion (LVO) stroke play an important role in testing novel thrombolytic and neuroprotective agents, as well as assessing endovascular devices for endovascular thrombectomy. Depending on the modality used to mo
Externí odkaz:
https://doaj.org/article/8ec01e23c2d040e395e240449fd17395
Autor:
Layne Dylla, Hannah M. Higgins, Christi Piper, Sharon N. Poisson, Paco S. Herson, Andrew A. Monte
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Women continue to face a greater lifetime morbidity and mortality from stroke and have been shown to respond differently to stroke treatments compared to men. Since 2016, updated National Institutes of Health (NIH) policies require research studies t
Externí odkaz:
https://doaj.org/article/aa47c320f0984225931903e12fea9c8c
Publikováno v:
Neurobiology of Disease, Vol 165, Iss , Pp 105647- (2022)
Ischemic stroke is a devastating health problem, affecting approximately 800,000 patients in the US every year, making it the leading cause of combined death and disability in the country. Stroke has historically been thought of as predominantly impa
Externí odkaz:
https://doaj.org/article/3baca8df43ff42e2a2a2b98449169845
Autor:
Jonathan E. Tullis, Olivia R. Buonarati, Steven J. Coultrap, Ashley M. Bourke, Erika L. Tiemeier, Matthew J. Kennedy, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103214- (2021)
Summary: Binding of two different CaM kinases, CaMKII and DAPK1, to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 has been implicated in excitotoxic/ischemic neuronal cell death. The GluN2BΔCaMKII mutation (L1298A, R1300Q) is ne
Externí odkaz:
https://doaj.org/article/f415611452a44fc8862991682f4e7cfa
Autor:
Giuseppe Giannotti, Sheng Gong, Nicholas Fayette, Jasper A. Heinsbroek, James E. Orfila, Paco S. Herson, Christopher P. Ford, Jamie Peters
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109605- (2021)
Summary: Here, we use optogenetics and chemogenetics to investigate the contribution of the paraventricular thalamus (PVT) to nucleus accumbens (NAc) pathway in aversion and heroin relapse in two different heroin self-administration models in rats. I
Externí odkaz:
https://doaj.org/article/871e82e44d15409d9fd6859a44b79a3a
Autor:
Robert M. Dietz, James E. Orfila, Nicholas Chalmers, Crystal Minjarez, Jose Vigil, Guying Deng, Nidia Quillinan, Paco S. Herson
Publikováno v:
Neural Plasticity, Vol 2021 (2021)
Hippocampal cell death and cognitive dysfunction are common following global cerebral ischemia across all ages, including children. Most research has focused on preventing neuronal death. Restoration of neuronal function after cell death is an altern
Externí odkaz:
https://doaj.org/article/ad771fd826114abfbaf35764d9da482c
Autor:
Francesca M. Manzella, Srdjan M. Joksimovic, James E. Orfila, Brier R. Fine, Robert M. Dietz, Dayalan Sampath, Hanna K. Fiedler, Vesna Tesic, Navya Atluri, Yogendra H. Raol, Vesna Jevtovic-Todorovic, Paco S. Herson, Slobodan M. Todorovic
Publikováno v:
Frontiers in Systems Neuroscience, Vol 14 (2020)
Exposure to sedative/hypnotic and anesthetic drugs, such as ketamine, during the critical period of synaptogenesis, causes profound neurotoxicity in the developing rodent and primate brains and is associated with poor cognitive outcomes later in life
Externí odkaz:
https://doaj.org/article/6400fe4506a6401cba3fada97de7ec1f
Autor:
Olivia R. Buonarati, Sarah G. Cook, Dayton J. Goodell, Nicholas E. Chalmers, Nicole L. Rumian, Jonathan E. Tullis, Susana Restrepo, Steven J. Coultrap, Nidia Quillinan, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 1-8.e4 (2020)
Summary: DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here, we show that mutating the binding region on GluN2B (L129
Externí odkaz:
https://doaj.org/article/0747266e16f346cea222f1e38a2efe82
Autor:
Guiying Deng, James E. Orfila, Robert M. Dietz, Myriam Moreno-Garcia, Krista M. Rodgers, Steve J. Coultrap, Nidia Quillinan, Richard J. Traystman, K. Ulrich Bayer, Paco S. Herson
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1109-1117 (2017)
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of physiological glutamate signaling, but its role in pathological glutamate signaling (excitotoxicity) remains less clear, with indications for both neuro-toxic and neuro-p
Externí odkaz:
https://doaj.org/article/03641caf92b14ff7b118d94776af0722