Zobrazeno 1 - 10
of 600
pro vyhledávání: '"Pacis A"'
Autor:
Yu Gu, Tarek Taifour, Tung Bui, Dongmei Zuo, Alain Pacis, Alexandre Poirier, Sherif Attalla, Anne-Marie Fortier, Virginie Sanguin-Gendreau, Tien-Chi Pan, Vasilios Papavasiliou, Nancy U. Lin, Melissa E. Hughes, Kalie Smith, Morag Park, Michel L. Tremblay, Lewis A. Chodosh, Rinath Jeselsohn, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes. In this study, we identify tumo
Externí odkaz:
https://doaj.org/article/ce14835d262d4ceaae4ee74374578c4b
Autor:
Ipshita Nandi, Linjia Ji, Harvey W. Smith, Daina Avizonis, Vasilios Papavasiliou, Cynthia Lavoie, Alain Pacis, Sherif Attalla, Virginie Sanguin-Gendreau, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic reprogramming, a hallmark of tumorigenesis, involves alterations in glucose and fatty acid metabolism. Here, we investigate the role of Carnitine palmitoyl transferase 1a (Cpt1a), a key enzyme in long-chain fatty acid (LCFA) oxidat
Externí odkaz:
https://doaj.org/article/052dee2b00604ae3ada71ece23a9fb36
Autor:
Marco Biondini, Camille Lehuédé, Sébastien Tabariès, Matthew G. Annis, Alain Pacis, Eric H. Ma, Christine Tam, Brian E. Hsu, Yannick Audet-Delage, Afnan Abu-Thuraia, Charlotte Girondel, Valerie Sabourin, Stephanie P. Totten, Mariana de Sá Tavares Russo, Gaëlle Bridon, Daina Avizonis, Marie-Christine Guiot, Julie St-Pierre, Josie Ursini-Siegel, Russell Jones, Peter M. Siegel
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103276- (2024)
Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously
Externí odkaz:
https://doaj.org/article/9541bdda466b464aac43f308bd0b1d8e
Autor:
Biondini, Marco, Lehuédé, Camille, Tabariès, Sébastien, Annis, Matthew G., Pacis, Alain, Ma, Eric H., Tam, Christine, Hsu, Brian E., Audet-Delage, Yannick, Abu-Thuraia, Afnan, Girondel, Charlotte, Sabourin, Valerie, Totten, Stephanie P., de Sá Tavares Russo, Mariana, Bridon, Gaëlle, Avizonis, Daina, Guiot, Marie-Christine, St-Pierre, Julie, Ursini-Siegel, Josie, Jones, Russell, Siegel, Peter M.
Publikováno v:
In Redox Biology September 2024 75
Autor:
Scarlette Pacis, Anna Bolzani, Alexander Heuck, Klaus Gossens, Mathias Kruse, Björn Fritz, Ulf Maywald, Thomas Wilke, Christian Kunz
Publikováno v:
Oncology and Therapy, Vol 12, Iss 2, Pp 293-309 (2024)
Abstract Introduction The objective of this study was to investigate the prevalence, incidence, and treatment patterns (treatment regimens, switches, duration) for diffuse large B-cell lymphoma (DLBCL) in a real-world setting. Methods This was a retr
Externí odkaz:
https://doaj.org/article/44aed4df83c747c89e415344f2a2e45e
Autor:
Elena Kuzmin, Toby M. Baker, Tom Lesluyes, Jean Monlong, Kento T. Abe, Paula P. Coelho, Michael Schwartz, Joseph Del Corpo, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G. Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L. Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113988- (2024)
Summary: The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. A
Externí odkaz:
https://doaj.org/article/037f03f6925f4a5d977165ac992225f6
Autor:
Kuzmin, Elena, Baker, Toby M., Lesluyes, Tom, Monlong, Jean, Abe, Kento T., Coelho, Paula P., Schwartz, Michael, Del Corpo, Joseph, Zou, Dongmei, Morin, Genevieve, Pacis, Alain, Yang, Yang, Martinez, Constanza, Barber, Jarrett, Kuasne, Hellen, Li, Rui, Bourgey, Mathieu, Fortier, Anne-Marie, Davison, Peter G., Omeroglu, Atilla, Guiot, Marie-Christine, Morris, Quaid, Kleinman, Claudia L., Huang, Sidong, Gingras, Anne-Claude, Ragoussis, Jiannis, Bourque, Guillaume, Van Loo, Peter, Park, Morag
Publikováno v:
In Cell Reports 23 April 2024 43(4)
Autor:
Gloria Rey-Benito, Desirée Pastor, Alvaro Whittembury, Regina Durón, Carmelita Pacis-Tirso, Pamela Bravo-Alcántara, Claudia Ortiz, Jon Andrus
Publikováno v:
Vaccines, Vol 12, Iss 6, p 690 (2024)
This report reviews national data from all Member States on measles, rubella, and congenital rubella syndrome (CRS) elimination in the Region of the Americas during 2019–2023. It includes an analysis of compliance with vaccination coverage, surveil
Externí odkaz:
https://doaj.org/article/2b7aea4b495648bd92913d68b2da5556
Autor:
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura M. Williamson, Barbara Grünwald, Grainne M. O’Kane, Steven J. M. Jones, Marco. A. Marra, Julie M. Wilson, Steven Gallinger, Janessa Laskin, George Zogopoulos
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Improved predictors of T cell-inflammation are needed to identify ICI-responsive tumor
Externí odkaz:
https://doaj.org/article/8dd7df9c6c22430ba3c3588f08acd012
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 366-380 (2023)
Autosomal dominant polycystic kidney disease (ADPKD) causes renal cysts and leads to end-stage renal disease in midlife due mainly to PKD1 gene mutations. Virtually no studies have explored gene therapeutic strategies for long-term effective treatmen
Externí odkaz:
https://doaj.org/article/1ef90b1e73d44b9a81a57cf4168e4457