Pharmacokinetic-pharmacodynamic correlation of imipenem in pediatric burn patients using a bioanalytical liquid chromatographic method

Autor: Carlindo Vieira da Silva Junior, Silvia Regina Cavani Jorge Santos, Cristina Sanches-Giraud, David de Souza Gomez

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 51, Iss 2, Pp 305-315 (2015)
Brazilian Journal of Pharmaceutical Sciences, Volume: 51, Issue: 2, Pages: 305-315, Published: JUN 2015
Brazilian Journal of Pharmaceutical Sciences; Vol. 51 No. 2 (2015); 305-315
Brazilian Journal of Pharmaceutical Sciences; Vol. 51 Núm. 2 (2015); 305-315
Brazilian Journal of Pharmaceutical Sciences; v. 51 n. 2 (2015); 305-315
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

A bioanalytical method was developed and applied to quantify the free imipenem concentrations for pharmacokinetics and PK/PD correlation studies of the dose adjustments required to maintain antimicrobial effectiveness in pediatric burn patients. A re

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