Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry.

Autor: Kalaba, Predrag¹ (AUTHOR) predrag.kalaba@univie.ac.at, Pacher, Katharina¹ (AUTHOR) katharina.pacher@gmx.net, Neill, Philip John¹ (AUTHOR) phneill@gmx.at, Dragacevic, Vladimir¹ (AUTHOR) dragacevicvladimir@gmail.com, Zehl, Martin^2,3 (AUTHOR) martin.zehl@univie.ac.at, Wackerlig, Judith¹ (AUTHOR) judith.wackerlig@univie.ac.at, Kirchhofer, Michael¹ (AUTHOR) mikey.k.mb@gmail.com, Sartori, Simone B.⁴ (AUTHOR) simone.sartori@uibk.ac.at, Gstach, Hubert¹ (AUTHOR) hubert.gstach@univie.ac.at, Kouhnavardi, Shima¹ (AUTHOR) shima.kouhnavardi@gmail.com, Fabisikova, Anna² (AUTHOR) anna.fabisikova@univie.ac.at, Pillwein, Matthias¹ (AUTHOR) matthias.pillwein@icloud.com, Monje-Quiroga, Francisco⁵ (AUTHOR) francisco.monjequiroga@meduniwien.ac.at, Ebner, Karl⁴ (AUTHOR) karl.ebner@uibk.ac.at, Prado-Roller, Alexander⁶ (AUTHOR) alexander.roller@univie.ac.at, Singewald, Nicolas⁴ (AUTHOR) nicolas.singewald@uibk.ac.at, Urban, Ernst¹ (AUTHOR) ernst.urban@univie.ac.at, Langer, Thierry¹ (AUTHOR) thierry.langer@univie.ac.at, Pifl, Christian⁷ (AUTHOR) christian.pifl@meduniwien.ac.at, Lubec, Jana⁸ (AUTHOR) jana.aradska@gmail.com

Publikováno v: Biomolecules (2218-273X). Sep2023, Vol. 13 Issue 9, p1415. 40p.

Pre-clinical evaluation of the binding properties of potential muscarinic acetylcholine receptor ligands

Autor: Pacher, Katharina

Die muskarinischen Acetylcholinrezeptoren (mAChR) gehören zur Familie der G-Protein- gekoppelten Rezeptoren und befinden sich hauptsächlich im zentralen Nervensystem. Die mAChR spielen eine wichtige Rolle in verschiedenen neuronalen Funktionen un

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