Phosphorylation of cytosolic hPGK1 affects protein stability and ligand binding: implications for its subcellular targeting in cancer.

Autor: Pacheco-García JL; Departamento de Química Física, Universidad de Granada, Spain., Cano-Muñoz M; Departamento de Química Física, Universidad de Granada, Spain., Loginov DS; Institute of Microbiology - BioCeV, Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Vankova P; Institute of Biotechnology - BioCeV, Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Man P; Institute of Microbiology - BioCeV, Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Pey AL; Departamento de Química Física, Unidad de Excelencia en Química Aplicada a Biomedicina y Medioambiente e Instituto de Biotecnología, Universidad de Granada, Spain.

Publikováno v: The FEBS journal [FEBS J] 2024 Nov; Vol. 291 (21), pp. 4775-4795. Date of Electronic Publication: 2024 Sep 06.

Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme.

Autor: Pacheco-García JL; Departamento de Química Física, Universidad de Granada, Spain., Anoz-Carbonell E; Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI) (GBsC-CSIC Joint Unit), Universidad de Zaragoza, Spain., Loginov DS; Institute of Microbiology - BioCeV, Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Kavan D; Institute of Microbiology - BioCeV, Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Salido E; Center for Rare Diseases (CIBERER), Hospital Universitario de Canarias, Universidad de la Laguna, Tenerife, Spain., Man P; Institute of Microbiology - BioCeV, Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Medina M; Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI) (GBsC-CSIC Joint Unit), Universidad de Zaragoza, Spain., Pey AL; Departamento de Química Física, Unidad de Excelencia en Química Aplicada a Biomedicina y Medioambiente e Instituto de Biotecnología, Universidad de Granada, Spain.

Publikováno v: The FEBS journal [FEBS J] 2023 Apr; Vol. 290 (7), pp. 1855-1873. Date of Electronic Publication: 2022 Nov 25.

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1.

Autor: Salido E; Centre for Biomedical Research on Rare Diseases (CIBERER), Hospital Universitario de Canarias, 38320 Tenerife, Spain., Timson DJ; School of Pharmacy and Biomolecular Sciences, The University of Brighton, Brighton BN2 4GJ, UK., Betancor-Fernández I; Centre for Biomedical Research on Rare Diseases (CIBERER), Hospital Universitario de Canarias, 38320 Tenerife, Spain., Palomino-Morales R; Department of Biochemistry and Molecular Biology I, Faculty of Sciences and Biomedical Research Center (CIBM), University of Granada, 18071 Granada, Spain., Anoz-Carbonell E; Department of Biochemistry and Molecular and Cellular Biology, Faculty of Sciences, Institute of Biocomputation and Physics of Complex Systems (GBsC-CSIC Joint Unit), University of Zaragoza, 50009 Zaragoza, Spain., Pacheco-García JL; Department of Physical Chemistry, University of Granada, 18071 Granada, Spain., Medina M; Department of Biochemistry and Molecular and Cellular Biology, Faculty of Sciences, Institute of Biocomputation and Physics of Complex Systems (GBsC-CSIC Joint Unit), University of Zaragoza, 50009 Zaragoza, Spain., Pey AL; Unit of Excellence in Chemistry, Department of Physical Chemistry, Institute of Biotechnology, University of Granada, 18071 Granada, Spain.

Publikováno v: Journal of personalized medicine [J Pers Med] 2022 May 05; Vol. 12 (5). Date of Electronic Publication: 2022 May 05.

Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability.

Autor: Medina-Carmona E; Department of Physical Chemistry, University of Granada, 18071 Granada, Spain., Rizzuti B; CNR-NANOTEC, Licryl-UOS Cosenza and CEMIF.Cal, Department of Physics, University of Calabria, 87036 Rende, Italy., Martín-Escolano R; Department of Parasitology, Instituto de Investigación Biosanitaria (ibs.Granada), Hospitales Universitarios De Granada/University of Granada, 18071 Granada, Spain., Pacheco-García JL; Department of Physical Chemistry, University of Granada, 18071 Granada, Spain., Mesa-Torres N; Department of Physical Chemistry, University of Granada, 18071 Granada, Spain., Neira JL; Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Avda. del Ferrocarril s/n, 03202 Elche, Alicante, Spain; Instituto de Biocomputación y Física de los Sistemas Complejos (BIFI), 50009 Zaragoza, Spain., Guzzi R; CNR-NANOTEC, Licryl-UOS Cosenza and CEMIF.Cal, Department of Physics, University of Calabria, 87036 Rende, Italy; Molecular Biophysics Laboratory, Department of Physics, University of Calabria, 87036 Rende, Italy., Pey AL; Department of Physical Chemistry, University of Granada, 18071 Granada, Spain. Electronic address: angelpey@ugr.es.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2019 Mar 15; Vol. 125, pp. 1275-1288. Date of Electronic Publication: 2018 Sep 19.