Zobrazeno 1 - 10
of 1 322
pro vyhledávání: '"Pacak P"'
Autor:
Oluigboa, David C., Santra, Bikash, Mathai, Tejas Sudharshan, Mukherjee, Pritam, Liu, Jianfei, Jha, Abhishek, Patel, Mayank, Pacak, Karel, Summers, Ronald M.
Pheochromocytomas and Paragangliomas (PPGLs) are rare adrenal and extra-adrenal tumors which have the potential to metastasize. For the management of patients with PPGLs, CT is the preferred modality of choice for precise localization and estimation
Externí odkaz:
http://arxiv.org/abs/2402.08697
Publikováno v:
BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Thymic neuroendocrine tumor as a cause of Cushing syndrome is extremely rare in children. Case presentation We report a case of a 10-year-old girl who presented with typical symptoms and signs of hypercortisolemia, including bone
Externí odkaz:
https://doaj.org/article/3fdbe77b3fd1486084cca3584631b063
Autor:
Monika Chauhan, Audrey L. Daugherty, Fatemeh (Ellie) Khadir, Ozgun F. Duzenli, Alexandra Hoffman, Jennifer A. Tinklenberg, Peter B. Kang, George Aslanidi, Christina A. Pacak
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Highly efficient adeno associated viruses (AAVs) targeting the central nervous system (CNS) are needed to deliver safe and effective therapies for inherited neurological disorders. The goal of this study was to compare the organ-specific tra
Externí odkaz:
https://doaj.org/article/cafeb29b8b2c4e6c854217899ac3adad
Publikováno v:
Clinical Case Reports, Vol 12, Iss 10, Pp n/a-n/a (2024)
Key Clinical Message Pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries, paragangliomas, and syringomyelia are uncommon diseases. Furthermore, in the absence of any genetic link and with less than five repor
Externí odkaz:
https://doaj.org/article/4d64c180f9d347a58e89f872f2a4735a
Autor:
Briana N. Cortez, Mickey J. M. Kuo, Abhishek Jha, Mayank Patel, Jorge A. Carrasquillo, Tamara Prodanov, Kailah M. Charles, Sara Talvacchio, Alberta Derkyi, Frank I. Lin, David Taïeb, Jaydira Del Rivero, Karel Pacak
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Few reports have highlighted the rare presence of somatic ATRX variants in clinically aggressive, metastatic pheochromocytoma/paraganglioma (PCC/PGL); however, none have addressed detailed clinical presentation (including biochemistry and imaging) an
Externí odkaz:
https://doaj.org/article/24454dee70a44c98a12a8b2e8affd5e7
Autor:
Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova, Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova, Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K. Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini, T. M. Iverson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Complex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the le
Externí odkaz:
https://doaj.org/article/a63f5096183a4241a866d4154beb8b16
Autor:
Herui Wang, Rogelio Medina, Juan Ye, Yaping Zhang, Samik Chakraborty, Alex Valenzuela, Ondrej Uher, Katerina Hadrava Vanova, Mitchell Sun, Xueyu Sang, Deric M. Park, Jan Zenka, Mark R. Gilbert, Karel Pacak, Zhengping Zhuang
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract Despite strides in immunotherapy, glioblastoma multiforme (GBM) remains challenging due to low inherent immunogenicity and suppressive tumor microenvironment. Converting “cold” GBMs to “hot” is crucial for immune activation and impro
Externí odkaz:
https://doaj.org/article/402be77c1897447c8a899980d3ead908
Autor:
Feiqiong Gao, Qigu Yao, Jiaqi Zhu, Wenyi Chen, Xudong Feng, Bing Feng, Jian Wu, Karel Pacak, Jared Rosenblum, Jiong Yu, Zhengping Zhuang, Hongcui Cao, Lanjuan Li
Publikováno v:
Pharmacological Research, Vol 202, Iss , Pp 107135- (2024)
Externí odkaz:
https://doaj.org/article/b0437a71e28744fb90f180ab576558f6
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract JUNO-IZUMO1 binding is the first known physical link created between the sperm and egg membranes in fertilization, however, how this initiates sperm-egg fusion remains elusive. As advanced structural insights will help to combat the infertil
Externí odkaz:
https://doaj.org/article/1090dd0ecbbc4ad8aa88def8ba9915ac
Autor:
Christina A. Pacak, Silveli Suzuki-Hatano, Fatemeh Khadir, Audrey L. Daugherty, Mughil Sriramvenugopal, Bennett J. Gosiker, Peter B. Kang, William Todd Cade
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Introduction The promising potential of adeno-associated virus (AAV) gene delivery strategies to treat genetic disorders continues to grow with an additional three AAV-based therapies recently approved by the Food and Drug Administration and
Externí odkaz:
https://doaj.org/article/f69833ae695641cf9607659cc8cf2067