Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes.

Autor: Geny S; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden., Moreno PM; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden INEB-Instituto de Engenharia Biomedica, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal., Krzywkowski T; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-171 21, Sweden., Gissberg O; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden., Andersen NK; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., Isse AJ; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., El-Madani AM; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., Lou C; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., Pabon YV; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden., Anderson BA; Department of Chemistry, University of Idaho, Moscow, ID 83844, USA., Zaghloul EM; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden., Zain R; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden Centre for Rare Diseases, Department of Clinical Genetics, Karolinska University Hospital, SE-171 76 Stockholm, Sweden., Hrdlicka PJ; Department of Chemistry, University of Idaho, Moscow, ID 83844, USA., Jørgensen PT; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., Nilsson M; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-171 21, Sweden., Lundin KE; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden., Pedersen EB; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., Wengel J; Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, Nucleic Acid Centre, University of Southern Denmark, 5230 Odense, Denmark., Smith CI; Department of Laboratory Medicine, Karolinska Institutet and Clinical Research Center, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden edvard.smith@ki.se.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2016 Mar 18; Vol. 44 (5), pp. 2007-19. Date of Electronic Publication: 2016 Feb 08.

Cyclodextrin-peptide conjugates for sequence specific DNA binding.

Autor: Ruiz García Y; Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 (S4), B-9000 Ghent, Belgium. annemieke.madder@ugent.be., Zelenka J, Pabon YV, Iyer A, Buděšínský M, Kraus T, Smith CI, Madder A

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2015 May 14; Vol. 13 (18), pp. 5273-8.

Artificial genetic polymers against human pathologies.

Autor: Ivanov, Gleb S.^1,2 (AUTHOR), Tribulovich, Vyacheslav G.² (AUTHOR), Pestov, Nikolay B.^3,4,5,6 (AUTHOR), David, Temitope I.⁴ (AUTHOR), Amoah, Abdul-Saleem⁴ (AUTHOR), Korneenko, Tatyana V.⁵ (AUTHOR), Barlev, Nikolai A.^1,6,7 (AUTHOR) nick.a.barlev@gmail.com

Publikováno v: Biology Direct. 12/6/2022, Vol. 17 Issue 1, p1-21. 21p.

Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)n Repeats by PNA or LNA Targeting.

Autor: Bergquist, Helen^1,2, Rocha, Cristina S. J.², Álvarez-Asencio, Rubén³, Nguyen, Chi-Hung⁴, Rutland, Mark. W.³, Smith, C. I. Edvard², Good, Liam⁵, Nielsen, Peter E.⁶, Zain, Rula^2,7 rula.zain@ki.se

Publikováno v: PLoS ONE. 11/15/2016, Vol. 11 Issue 11, p1-24. 24p.

Chemistry of Nucleic Acids

Autor: Harri Lönnberg

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synt