Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pablo de Leon"'
Publikováno v:
Life Sciences in Space Research. 38:59-66
Humans have stepped on the Lunar surface for less than 80 h of Extravehicular Activity, providing a narrow understanding of Lunar gait patterns. NASA’s Human-crewed Artemis missions are quickly approaching; understanding how fractional gravity affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df2295af2c2e3cedce49949b7872415
https://doi.org/10.1016/j.lssr.2023.05.004
https://doi.org/10.1016/j.lssr.2023.05.004
Autor:
Wenjun Fan, Hester Liu, Asma Begum, Stephanie Pitts, Brittany Ford, Tony Dorado, Pablo de Leon, Rajeshkumar NV, James C. Barrow, Marikki Laiho
Publikováno v:
Cancer Research. 82:2644-2644
RNA polymerase I inhibitors represent a new class of cancer therapeutics with potential application in many cancer types. By curbing the transcription of ribosomal RNAs they block the rate-limiting step in ribosome biogenesis and protein synthesis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f14519b1bcfbf01d97921c7a1d32a9
https://doi.org/10.1158/1538-7445.am2022-2644
https://doi.org/10.1158/1538-7445.am2022-2644
Publikováno v:
Theory and Practice of Computation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f0fad2e9adbe5fa1064327ba1ada8a
https://doi.org/10.1142/9789813234079_0011
https://doi.org/10.1142/9789813234079_0011
Publikováno v:
SIGITE/RIIT
ConnectUP is the proposed academic social networking application for the University of the Philippines (UP) System. This application may be used by students and employees of UP as an avenue for communication and finding possible collaborators with re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a35a841af4036ab7f5b0262cee458dae
https://doi.org/10.1145/2978192.2978246
https://doi.org/10.1145/2978192.2978246
Autor:
Amy S. Espeseth, Ivory D. Hills, Shawn J. Stachel, Thomas G. Steele, Georgia B. McGaughey, Sharie J. Haugabook, Samuel L. Graham, Paul Zuck, Timothy Allison, Pablo De Leon, Ashley Nomland, Katherine Tugusheva, Dennis Colussi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:17-20
A small molecule inhibitor of beta-secretase with a unique binding mode has been developed. Crystallographic determination of the enzyme-inhibitor complex shows the catalytic aspartate residues in the active site are not engaged in inhibitor binding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f34b06add72f13c29e702f2f0a1a68
https://doi.org/10.1016/j.bmcl.2008.11.027
https://doi.org/10.1016/j.bmcl.2008.11.027
Autor:
Pablo De León
¿Quién es Sergio Massa? ¿Cómo ha llegado a emerger como figura en el mapa político nacional este joven intendente de poco más de cuarenta años?'Sobre una contradicción -un oxímoron, en retórica- Sergio Massa construyó en unas pocas semanas
Autor:
Ashley Nomland, Dennis Colussi, Tim J. Allison, Samuel L. Graham, M. Katharine Holloway, Pablo De Leon, Hemaka A. Rajapakse, Hong Zhu, Sharie J. Haugabook, Sanjeev Munshi, Shawn J. Stachel, Ivory D. Hills, Beth Pietrak, Dawn Toolan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4993-4995
During our ongoing efforts to develop a small molecule inhibitor targeting the β-amyloid cleaving enzyme (BACE-1), we discovered a class of compounds bearing an aminoimidazole motif. Initial optimization led to potent compounds that have high Pgp ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21d58ec67fa0c78f7af660cdc17a4c
https://doi.org/10.1016/j.bmcl.2009.07.071
https://doi.org/10.1016/j.bmcl.2009.07.071
Autor:
Sabrina Castellano, Fuyuhiko Tamanoi, Masaru Watanabe, Ohyun Kwon, Sape S. Kinderman, Hannah D. G. Fiji, Pablo De Leon
Publikováno v:
Journal of the American Chemical Society. 129:5843-5845
Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c2ce14754fb2d0e78c0dbb55b1a077
https://doi.org/10.1021/ja070274n
https://doi.org/10.1021/ja070274n