Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pablo Serrano Fernandez"'
Autor:
Natasha L. Patel‐Murray, Luqing Zhang, Brian L. Claggett, Dongchu Xu, Pablo Serrano‐Fernandez, Margaret Healey, Simon Wandel, Chien‐Wei Chen, Jaison Jacob, Huilei Xu, Gordon M. Turner, William Chutkow, Denise P. Yates, Christopher J. O'Donnell, Margaret F. Prescott, Martin Lefkowitz, Claudio R. Gimpelewicz, Michael T. Beste, Faye Zhao, Liangke Gou, Akshay S. Desai, Pardeep S. Jhund, Milton Packer, Marc A. Pfeffer, Margaret M. Redfield, Jean L. Rouleau, Faiez Zannad, Michael R. Zile, John J. V. McMurray, Michael M. Mendelson, Scott D. Solomon, Jonathan W. Cunningham
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background Prognostic markers and biological pathways linked to detrimental clinical outcomes in heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. Methods and Results We measured serum levels of 4123 unique proteins
Externí odkaz:
https://doaj.org/article/e39880796038474e881ba373a0b6c360
Autor:
Sergio Kaiser, Luqing Zhang, Brit Mollenhauer, Jaison Jacob, Simonne Longerich, Jorge Del-Aguila, Jacob Marcus, Neha Raghavan, David Stone, Olumide Fagboyegun, Douglas Galasko, Mohammed Dakna, Bilada Bilican, Mary Dovlatyan, Anna Kostikova, Jingyao Li, Brant Peterson, Michael Rotte, Vinicius Sanz, Tatiana Foroud, Samantha J. Hutten, Mark Frasier, Hirotaka Iwaki, Andrew Singleton, Ken Marek, Karen Crawford, Fiona Elwood, Mirko Messa, Pablo Serrano-Fernandez
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract The pathogenesis and clinical heterogeneity of Parkinson’s disease (PD) have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of cerebrospinal fluid (CSF) opened new opportuni
Externí odkaz:
https://doaj.org/article/8a3707f40aec4528b1d8d9e56c321bac
Autor:
Luqing Zhang, Jonathan W. Cunningham, Brian L. Claggett, Jaison Jacob, Michael M. Mendelson, Pablo Serrano-Fernandez, Sergio Kaiser, Denise P. Yates, Margaret Healey, Chien-Wei Chen, Gordon M. Turner, Natasha L. Patel-Murray, Faye Zhao, Michael T. Beste, Jason M. Laramie, William T. Abraham, Pardeep S. Jhund, Lars Kober, Milton Packer, Jean Rouleau, Michael R. Zile, Margaret F. Prescott, Martin Lefkowitz, John J.V. McMurray, Scott D. Solomon, William Chutkow
BackgroundSystematically characterizing associations between circulating proteins and risk for subsequent clinical events may improve clinical risk prediction and shed light on unrecognized biological pathways in heart failure (HF). Large-scale assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f96fa9885a01159b17fe145ef22cf3c
https://eprints.gla.ac.uk/276213/1/276213.pdf
https://eprints.gla.ac.uk/276213/1/276213.pdf
Autor:
Kazuto Tsukita, Haruhi Sakamaki-Tsukita, Sergio Kaiser, Luqing Zhang, Mirko Messa, Pablo Serrano-Fernandez, Ryosuke Takahashi
The proteome encodes for various information. By quantifying 4071 human proteins in the cerebrospinal fluid using high-throughput affinity proteomics, this study aimed to extract proteomic signatures associated with Parkinson’s disease using unbias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a737e0e7ce676c3a143e1c26180311ae
https://doi.org/10.1101/2022.06.08.22276035
https://doi.org/10.1101/2022.06.08.22276035
Autor:
Mirko Messa, Sergio Kaiser, Luqing Zhang, Brit Mollenhauer, Jaison Jacob, Simonne Longerich, Jorge Del-Aguila, Jacob Marcus, Neha Raghavan, David Stone, Olumide Fagboyegun, Douglas Galasko, Mohammed Dakna, Bilada Bilican, Mary Dovlatyan, Anna Kostikova, Jingyao Li, Brant Peterson, Michael Rotte, Vinicius Sanz, Tatiana Foroud, Samantha Hutten, Mark Frasier, Hirotaka Iwaki, Andrew Singleton, Ken Marek, Karen Crawford, Fiona Elwood, Pablo Serrano-Fernandez
The pathogenesis and clinical heterogeneity of Parkinson’s disease have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of CSF has opened new opportunities for scrutinizing this heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9403f02e95fb814b3145723ee4cdca8
https://doi.org/10.1101/2022.03.09.22272131
https://doi.org/10.1101/2022.03.09.22272131
Autor:
Claudia Hon, Ma’en Obeidat, Jason M. Laramie, Philippe Marc, Pablo Serrano-Fernandez, Paul M. Ridker, Margaret L Healey, Michael T. Beste, Arkady I Gusev, Aviv Madar, Huilei Xu, Nicole Hartmann, Denise Yates, Scott Kennedy, Sergio Kaiser, Eric C. Svensson
Publikováno v:
Circulation: Genomic and Precision Medicine. 14
No formal abstract in format we plan to submit to journal (a short report). Informally, the work presented here adds to a body of evidence that shows how polygenic risk scores (PRS) for coronary artery disease (CAD) can be used to inform on patient's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19417bb8b0b5ac6a5dcd436b2108d314
https://doi.org/10.1161/circgen.121.003440
https://doi.org/10.1161/circgen.121.003440
Autor:
Pablo Serrano-Fernandez, Dagmara Dymerska, Grzegorz Kurzawski, Róża Derkacz, Tatiana Sobieszczańska, Zbigniew Banaszkiewicz, Hanno Roomere, Eneli Oitmaa, Andres Metspalu, Ramūnas Janavičius, Pavel Elsakov, Mindaugas Razumas, Kestutis Petrulis, Arvīds Irmejs, Edvīns Miklaševičs, Rodney J. Scott, Jan Lubiński
Publikováno v:
Gastroenterology Research and Practice, Vol 2015 (2015)
The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs69832
Externí odkaz:
https://doaj.org/article/0e84904d762f45cbb8bf659e1271863b
Autor:
Mark R, Morris, David J, Hughes, Ya-Min, Tian, Christopher J, Ricketts, Kah Weng, Lau, Dean, Gentle, Salwati, Shuib, Pablo, Serrano-Fernandez, Jan, Lubinski, Michael S, Wiesener, Christopher W, Pugh, Farida, Latif, Peter J, Ratcliffe, Eamonn R, Maher
Publikováno v:
Anticancer research. 29(11)
Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1alpha and -2alpha is a critical event in the pathogenesis of most clear cell renal cell carcinomas (RCC). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b4705ef800705f56a6913e7543d9532
https://pubmed.ncbi.nlm.nih.gov/20032376
https://pubmed.ncbi.nlm.nih.gov/20032376
Autor:
Steffen, Möller, Dirk, Koczan, Pablo, Serrano-Fernandez, Uwe K, Zettl, Hans-Jürgen, Thiesen, Saleh M, Ibrahim
Publikováno v:
In silico biology. 4(4)
Common complex polygenic diseases as autoimmune diseases have not been completely understood on a molecular level. While many genes are known to be involved in the pathways responsible for the phenotype, explicit causes for the susceptibility of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07b8903e59231e084d353cfec5978a0b
https://pubmed.ncbi.nlm.nih.gov/15506992
https://pubmed.ncbi.nlm.nih.gov/15506992
Autor:
Dagmara Dymerska, Pablo Serrano Fernandez, Ryszard Słomski, Krzysztof Kąklewski, Tomasz Byrski, Grzegorz Kurzawski, Jacek Gronwald, Tomasz Huzarski, Rodney J. Scott, Andrzej Pławski, Józef Kładny, Jan Lubinski, Janina Suchy
Publikováno v:
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice, Vol 9, Iss Suppl 2, p A9 (2011)
BASE-Bielefeld Academic Search Engine
Hereditary Cancer in Clinical Practice, Vol 9, Iss Suppl 2, p A9 (2011)
BASE-Bielefeld Academic Search Engine
Mutations of genes associated with the mismatch repair mechanism and mutations of the APC gene are the most frequent causes of hereditary colorectal cancer. An iPLEX test combined with TaqMan genotyping assays was therefore developed to identify comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8f67d5e0da49771b8cd521d5b7da47
http://europepmc.org/articles/PMC3108174
http://europepmc.org/articles/PMC3108174