Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Pablo Scharf"'
1
Akademický článek
GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients
Autor: Pablo Scharf, Silvana Sandri, Felipe Rizzetto, Luana Filippi Xavier, Daniela Grosso, Rebeca D. Correia-Silva, Pedro S. Farsky, Cristiane D. Gil, Sandra Helena Poliselli Farsky
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
IntroductionG-protein coupled receptors (GPCRs) expressed on neutrophils regulate their mobilization from the bone marrow into the blood, their half-live in the circulation, and their pro- and anti-inflammatory activities during inflammation. Chronic
Externí odkaz: https://doaj.org/article/5edfdded248342dca59b426ce59b6330
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2
Akademický článek
Neutrophil depletion in the pre-implantation phase impairs pregnancy index, placenta and fetus development
Autor: Cristina Bichels Hebeda, Anna Carolina Savioli, Pablo Scharf, Marina de Paula-Silva, Cristiane Damas Gil, Sandra Helena Poliselli Farsky, Silvana Sandri
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Maternal neutrophils cells are players in gestational tolerance and fetus delivery. Nonetheless, their actions in each phase of the pregnancy are unknown. We here investigated the role of maternal neutrophil depletion before the blastocyst implantati
Externí odkaz: https://doaj.org/article/661d09eaa11f45ca905c2675da0dd902
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3
Akademický článek
Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
Autor: Airton C. Martins, Miriam B. Virgolini, Daiana Silva Ávila, Pablo Scharf, Jung Li, Alexey A. Tinkov, Anatoly V. Skalny, Aaron B. Bowman, João B. T. Rocha, Michael Aschner
Publikováno v: Cells, Vol 12, Iss 17, p 2124 (2023)
Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of int
Externí odkaz: https://doaj.org/article/1d40ef63f0b148978e059548aa3ac2af
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4
Akademický článek
Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease
Autor: Pablo Scharf, Felipe Rizzetto, Luana Filippi Xavier, Sandra Helena Poliselli Farsky
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 18, p 10293 (2022)
Chronic kidney disease (CKD) is characterized as sustained damage to the renal parenchyma, leading to impaired renal functions and gradually progressing to end-stage renal disease (ESRD). Diabetes mellitus (DM) and arterial hypertension (AH) are unde
Externí odkaz: https://doaj.org/article/3ad647f985c2428396072bf98b5c90ab
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5
Akademický článek
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis
Autor: Pablo Scharf, Milena Fronza Broering, Gustavo Henrique Oliveira da Rocha, Sandra Helena Poliselli Farsky
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 19, p 6996 (2020)
Hematopoiesis is a complex and intricate process that aims to replenish blood components in a constant fashion. It is orchestrated mostly by hematopoietic progenitor cells (hematopoietic stem cells (HSCs)) that are capable of self-renewal and differe
Externí odkaz: https://doaj.org/article/42eb04c053954978ab9666580e7bfcd8
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6
Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis
Autor: Sandra Helena Poliselli Farsky, Tiago Franco de Oliveira, Ayda Henriques Schneider, Fernando Q. Cunha, Cíntia Scucuglia Heluany, Pablo Scharf, Walter dos Reis Pedreira Filho, Paula B. Donate
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Tobacco combustion exposure worsens rheumatoid arthritis (RA). Non-combustible tobacco devices, as heat-not-burn tobacco (HNBT), are emerging as harm reduction to smokers by releasing nicotine and lower combustible tobacco products. Nevertheless, HNB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd672f33203f8b6845f3477058b6c62c
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8
Pioglitazone-Mediated Attenuation of Experimental Colitis Relies on Cleaving of Annexin A1 Released by Macrophages
Autor: Silvya Stuchi Maria-Engler, Pablo Scharf, Sandra Helena Poliselli Farsky, Gustavo Henrique Oliveira da Rocha, Larissa Satiko Alcântara Sekimoto Matsuyama, Marina de Paula-Silva, Milena Fronza Broering
Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Ulcerative colitis and Crohn’s disease are chronic inflammatory bowel diseases (IBDs) which burden health systems worldwide; available pharmacological therapies are limited and cost-intensive. Use of peroxisome proliferator activated-receptor γ (P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482918d8644264744cc997e0b251b67
https://doi.org/10.3389/fphar.2020.591561
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9
Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functions
Autor: Pablo Scharf, Cíntia Scucuglia Heluany, Silvana Sandri, Walter dos Reis Pedreira Filho, Sandra Helena Poliselli Farsky, Gustavo Henrique Oliveira da Rocha
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cigarette smoke (CS) affects immune functions, leading to severe outcomes in smokers. Robust evidence addresses the immunotoxic effects of combustible tobacco products. As heat-not-burn tobacco products (HNBT) vaporize lower levels of combustible pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd59df03db74f601d64ea8f1134772f4
https://pubmed.ncbi.nlm.nih.gov/33126161
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10
Red light-emitting diode treatment improves tissue recovery in DSS-induced colitis in mice
Autor: Adriana Lino-dos-Santos-Franco, Sandra Helena Poliselli Farsky, Pablo Scharf, Milena Fronza Broering, Gustavo Henrique Oliveira da Rocha, Marina de Paula-Silva
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Inflammatory bowel diseases are debilitating illnesses characterized by severe inflammation of the gastrointestinal tract. Treatments currently available are expensive and ineffective. We here investigated the role of red-light emitting diode (LED) o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5214c8fb1b9b3024a7d1c91f14b72b40
https://pubmed.ncbi.nlm.nih.gov/32957067
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