Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Pablo Sanz de la Torre"'
Autor:
Cornelia Wagner, Hendrik-Jan Brouwer, Kasper D. Rand, Gerard Comamala, Pablo Sanz de la Torre, Rasmus U. Jakobsen, Maximiliane Hilger
Publikováno v:
Comamala, G, Wagner, C, de la Torre, P S, Jakobsen, R U, Hilger, M, Brouwer, H-J & Rand, K D 2020, ' Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor ', Analytica Chimica Acta, vol. 1115, pp. 41-51 . https://doi.org/10.1016/j.aca.2020.04.014
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has become a popular method for analysis of the conformational dynamics and interactions of proteins. Disulfide-bonded proteins, however, present a challenge to HDX-MS as they require efficient d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc0d61cc3a40329c5d0be218d8c8f2c
https://doi.org/10.1016/j.aca.2020.04.014
https://doi.org/10.1016/j.aca.2020.04.014
Autor:
Martijn M. Vanduijn, Hendrik-Jan Brouwer, Pablo Sanz de la Torre, Jean-Pierre Chervet, Theo M. Luider
Publikováno v:
Analytical Chemistry, 94(7), 3120-3125. American Chemical Society
Electrochemical reduction of intermolecular disulfide bridges has previously been demonstrated in immunoglobulins but failed to achieve reduction of intramolecular bonds. We now report an improved method that achieves the full reduction of both inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407c0d8c9237b360e9a32120f82596b9
https://pure.eur.nl/en/publications/521ae391-3f8c-4619-8461-31a4eec87f7d
https://pure.eur.nl/en/publications/521ae391-3f8c-4619-8461-31a4eec87f7d
