Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Pablo Rivera Mejías"'
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Akademický článek
The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
Autor: Pablo Rivera-Mejías, Álvaro Jesús Narbona-Pérez, Lidwina Hasberg, Lara Kroczek, Amir Bahat, Steffen Lawo, Kat Folz-Donahue, Anna-Lena Schumacher, Sofia Ahola, Fiona Carola Mayer, Patrick Giavalisco, Hendrik Nolte, Sergio Lavandero, Thomas Langer
Publikováno v: Cell Reports, Vol 42, Iss 4, Pp 112332- (2023)
Summary: The metabolic plasticity of mitochondria ensures cell development, differentiation, and survival. The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress signaling via DELE1 and orchestrates tumorigenesis and cell survival
Externí odkaz: https://doaj.org/article/5e2ae9642b664f2ca3c93a043e5f99f6
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2
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Autor: Elias Adriaenssens, Bob Asselbergh, Pablo Rivera-Mejías, Sven Bervoets, Leen Vendredy, Vicky De Winter, Katrien Spaas, Riet de Rycke, Gert van Isterdael, Francis Impens, Thomas Langer, Vincent Timmerman
Publikováno v: NATURE CELL BIOLOGY
Nature cell biology
Adriaenssens et al. provide evidence suggesting that cytosolic small heat shock proteins localize to the mitochondrial intermembrane space, where they operate as molecular chaperones. Mitochondria are complex organelles with different compartments, e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cbe01387ed2c4591e459deb51bdd34
https://doi.org/10.1038/s41556-022-01074-9
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3
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy
Autor: Sofia Ahola, Pablo Rivera Mejías, Steffen Hermans, Srikanth Chandragiri, Patrick Giavalisco, Hendrik Nolte, Thomas Langer
Publikováno v: Cell Metab
Cardiomyopathy and heart failure are common manifestations in mitochondrial disease caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria. Here, we demonstrate that the cardiac-specific loss of the assembly factor Co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1d2307e66ad98732d671d033abd30d
https://pubmed.ncbi.nlm.nih.gov/36113464
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5
Polycystin-2-dependent control of cardiomyocyte autophagy
Autor: Joseph A. Hill, Gabriele G. Schiattarella, Stefan Somlo, Pavan K. Battiprolu, Sergio Lavandero, Eugenia Morselli, Cristian Sotomayor-Flores, Valentina Parra, Pablo Rivera-Mejías, Elisa Villalobos, Alfredo Criollo, Herman I. May, Zully Pedrozo, Thomas G. Gillette, Humbert De Smedt, Francisco Altamirano, Dan L. Li, Nan Jiang
Publikováno v: Journal of molecular and cellular cardiology. 118
National Institutes of Health HL-120732 HL-128215 HL-126012 American Heart Association 14SFRN20510023 14SFRN20670003 16POST30680016 13POST16520009 Fondation Leducq 11CVD04 Cancer Prevention and Research Institute of Texas RP110486P3 PEW Latin America
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af8834a6b2370ccf538594ce025773e
https://pubmed.ncbi.nlm.nih.gov/29518398
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6
Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1
Autor: Paola Cea, Paola Rocco, Daniel Peña-Oyarzun, Mario Chiong, Cristian Ibarra, Clara Quiroga, Sergio Lavandero, Cristian Sotomayor-Flores, Alfredo Criollo, Loreto Carrasco, Pablo Rivera-Mejías
Publikováno v: Journal of Cellular Biochemistry. 115:712-720
In the heart, insulin-like growth factor-1 (IGF-1) is a peptide with pro-hypertrophic and anti-apoptotic actions. The pro-hypertrophic properties of IGF-1 have been attributed to the extracellular regulated kinase (ERK) pathway. Recently, we reported
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b79019b1411f25fba09b30d758a2ddf
https://doi.org/10.1002/jcb.24712
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7
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
Autor: Jovan Kuzmicic, Andrea del Campo, Camila López-Crisosto, Valentina Parra, Antonio Zorzano, Tomás Gutierrez, Pablo E. Morales, Beverly A. Rothermel, Mario Chiong, Christian Pennanen, Pablo Rivera-Mejías, Sergio Lavandero
Publikováno v: JOURNAL OF CELL SCIENCE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes of fusion and fission. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcecc6fd1393382ef22673fd99e29f3
https://pubmed.ncbi.nlm.nih.gov/24777478
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8
GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling
Autor: Mario Chiong, Cristian Sotomayor-Flores, Daniel Peña-Oyarzun, Pablo E. Morales, Felipe Paredes, Gloria Torres, Pablo Rivera-Mejías
Publikováno v: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria communication, as it allo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c0b62309016e5dd8465829599f4c48
https://pubmed.ncbi.nlm.nih.gov/24613839
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