Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pablo Rayff da Silva"'
Autor:
Caroline Leal Rodrigues Soares, Polrat Wilairatana, Larissa Rodrigues Silva, Polyanna Silva Moreira, Nayana Maria Medeiros Vilar Barbosa, Pablo Rayff da Silva, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115764- (2023)
Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical, and physio
Externí odkaz:
https://doaj.org/article/87dfe823d7cd4c0897553bc8275a5303
Autor:
Pablo Rayff da Silva, Nadjaele de Melo Apolinário, Simone Ângela Soares da Silva, Maria Elaine Cristina Araruna, Thássia Borges Costa, Yvnni M. S. de Medeiros e Silva, Teresinha Gonçalves da Silva, Ricardo Olímpio de Moura, Vanda Lucia dos Santos
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1415 (2023)
The N-acylhydrazone function has been reported as a pharmacophore group of molecules with diverse pharmacological activities, including anti-inflammatory effects. Therefore, this study was designed to evaluate the anti-inflammatory potential of the c
Externí odkaz:
https://doaj.org/article/6b05fe073dbc46118837537e5ecd7711
Autor:
Mayara dos Santos Maia, Francisco Jaime Bezerra Mendonça-Junior, Gabriela Cristina Soares Rodrigues, Adriano Soares da Silva, Niara Isis Pereira de Oliveira, Pablo Rayff da Silva, Cícero Francisco Bezerra Felipe, Ana Pavla Almeida Diniz Gurgel, Anuraj Nayarisseri, Marcus Tullius Scotti, Luciana Scotti
Publikováno v:
Molecules, Vol 28, Iss 16, p 6011 (2023)
Cancer is a multifactorial disease that continues to increase. Lignans are known to be important anticancer agents. However, due to the structural diversity of lignans, it is difficult to associate anticancer activity with a particular subclass. Ther
Externí odkaz:
https://doaj.org/article/8563f1c2169c44e1bfcb835e11365213
Autor:
Sonaly Lima Albino, Willian Charles da Silva Moura, Malu Maria Lucas dos Reis, Gleyton Leonel Silva Sousa, Pablo Rayff da Silva, Mayara Gabriele Carvalho de Oliveira, Tatiana Karla dos Santos Borges, Lucas Fraga Friaça Albuquerque, Sinara Mônica Vitalino de Almeida, Maria do Carmo Alves de Lima, Selma Aparecida Souza Kuckelhaus, Igor José dos Santos Nascimento, Francisco Jaime Bezerra Mendonca Junior, Teresinha Gonçalves da Silva, Ricardo Olímpio de Moura
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 204 (2023)
The present study proposed the synthesis of a novel acridine derivative not yet described in the literature, chemical characterization by NMR, MS, and IR, followed by investigations of its antileishmanial potential. In vitro assays were performed to
Externí odkaz:
https://doaj.org/article/247a914686cf4e85b890a1e5e5bd4db8
Autor:
Pablo Rayff da Silva, Renan Fernandes do Espírito Santo, Camila de Oliveira Melo, Fábio Emanuel Pachú Cavalcante, Thássia Borges Costa, Yasmim Vilarim Barbosa, Yvnni M. S. de Medeiros e Silva, Natália Ferreira de Sousa, Cristiane Flora Villarreal, Ricardo Olímpio de Moura, Vanda Lucia dos Santos
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 188 (2022)
The compound (E)-2-cyano-N,3-diphenylacrylamide (JMPR-01) was structurally developed using bioisosteric modifications of a hybrid prototype as formed from fragments of indomethacin and paracetamol. Initially, in vitro assays were performed to determi
Externí odkaz:
https://doaj.org/article/85db4375e4404b08839ab18499a6d0a8
Autor:
Luciana Scotti, Pablo Rayff da Silva, Jéssica Cabral de Andrade, Natália Ferreira de Sousa, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Maria Caroline Rodrigues Bezerra Remígio, Danielle da Nóbrega Alves, Humberto Hugo Nunes de Andrade, Arthur Lins Dias, Mirian Graciela da Silva Stiebbe Salvadori, Adriana Maria Fernandes de Oliveira Golzio, Ricardo Dias de Castro, Marcus T. Scotti, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida
Publikováno v:
Current Neuropharmacology. 21:842-866
Abstract: Alzheimer's and Parkinson's are neurodegenerative disorders that affect a great number of people around the world, seriously compromising the quality of life of individuals, due to motor and cognitive damage. In these diseases, pharmacologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e3777989d6ff89ff3d7d19327fd331
https://doi.org/10.2174/1570159x21666230221123059
https://doi.org/10.2174/1570159x21666230221123059
Autor:
Rayana Elias Maia, Bagnólia Araújo da Silva, Thallita Karla Silva do Nascimento Gonzaga, Pablo Rayff da Silva
Publikováno v:
Current Neuropharmacology. 20:1834-1849
Autism spectrum disorder (ASD) is a neurological condition that directly affects brain functions and can culminate in delayed intellectual development, problems in verbal communication, difficulties in social interaction, and stereotyped behaviors. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3c7bcd94aa153b578a73c5d664bd2a
https://doi.org/10.2174/1570159x19666210809102547
https://doi.org/10.2174/1570159x19666210809102547
Autor:
Luciana Scotti, Pablo Rayff da Silva, Natalia Diniz NunesPazos, Thallita Karla Silva do Nascimento Gonzaga, Jéssica Cabral de Andrade, Álefe Brito Monteiro, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara dos Santos Maia, Diogo Vilar da Fonsêca, Marcus T. Scotti, José Maria Barbosa Filho, Damião Pergentino de Sousa, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida
Publikováno v:
Current Topics in Medicinal Chemistry. 22:1530-1552
Introduction: Although drugs currently available for the treatment of anxiety and de-pression act through modulation of the neurotransmission systems involved in the neurobiology of the disorder, yet they often present side effects, which can impair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3772eaa31796d78622945b9b934bd509
https://doi.org/10.2174/1568026622666220505104726
https://doi.org/10.2174/1568026622666220505104726
Autor:
Ana Cláudia Dantas de Medeiros, Vanda Lucia Dos Santos, Raiff Dantas, Maria do Socorro Oliveira de Almeida, Francinalva Dantas de Medeiros, Hilton Albuquerque, Pablo Rayff Da Silva, Nadjaele Apolinário, Maria Elaine Cristina Araruna, Ingrid Cabral, Renaly Ivyna de Araújo Rêgo
Publikováno v:
Molecules
Volume 26
Issue 6
Molecules, Vol 26, Iss 1581, p 1581 (2021)
Volume 26
Issue 6
Molecules, Vol 26, Iss 1581, p 1581 (2021)
Spondias mombin L. (Anacardiaceae) has a worldwide distribution and is present in all regions of Brazil. Its leaves, flowers and bark are used as teas in folk medicine to treat diseases of the digestive system. This study aimed to evaluate the acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24b6086a42da17fc598cb33e101c77e
http://europepmc.org/articles/PMC8001497
http://europepmc.org/articles/PMC8001497
Autor:
Ricardo Dias de Castro, Reinaldo Nóbrega de Almeida, Marcus Tullius Scotti, Humberto Hugo Nunes de Andrade, Pablo Rayff da Silva, Damião Pergentino de Sousa, Thallita Karla Silva do Nascimento Gonzaga, Danielle da Nóbrega Alves, Mayara Dos Santos Maia, Álefe Brito Monteiro, Jéssica Cabral de Andrade
Publikováno v:
BioMed Research International, Vol 2021 (2021)
Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evaluate the pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ce427ebb41fdca6842ace4ac016147
https://doaj.org/article/b62716d047a645a2b417ae2cc9c510f5
https://doaj.org/article/b62716d047a645a2b417ae2cc9c510f5