Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pablo R. Freire"'
Autor:
Samuel O Skinner, Heng Xu, Sonal Nagarkar-Jaiswal, Pablo R Freire, Thomas P Zwaka, Ido Golding
Publikováno v:
eLife, Vol 5 (2016)
Transcription is a highly stochastic process. To infer transcription kinetics for a gene-of-interest, researchers commonly compare the distribution of mRNA copy-number to the prediction of a theoretical model. However, the reliability of this procedu
Externí odkaz:
https://doaj.org/article/a50ec689bdd14cb0a8eaf4f0ea82da76
Autor:
Loc Nguyen, Anil K. Panigrahi, Pablo R. Freire, Ryan P. Duren, Orla M. Conneely, Cristian Coarfa, S. Greg Call, Sandra L. Grimm
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Epigenetic reprogramming in Acute Myeloid Leukemia (AML) leads to the aberrant activation of super enhancer (SE) landscapes that drive the expression of key oncogenes, including the oncogenic MYC pathway. These SEs have been identified as promising t
Autor:
Marion Dejosez, Michael D. Schneider, Thomas P. Zwaka, Preethi H. Gunaratne, Cristian Coarfa, Pablo R. Freire, Jun Fujita, Ashley Benham
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1562-1573 (2017)
Cell Reports
Cell Reports
Summary Ronin (THAP11), a DNA-binding protein that evolved from a primordial DNA transposon by molecular domestication, recognizes a hyperconserved promoter sequence to control developmentally and metabolically essential genes in pluripotent stem cel
Autor:
Michele S. Redell, Steven G Call, Ryan P. Duren, Loc Nguyen, Pablo R. Freire, Seth P. Boudreaux, Orla M. Conneely, Padmini Narayanan
Publikováno v:
Leukemia
NR4As are AML tumor suppressors that are frequently silenced in human acute myeloid leukemia (AML). Despite their potential as novel targets for therapeutic intervention, mechanisms of NR4A silencing and strategies for their reactivation remain poorl
Autor:
Orla M. Conneely, Pablo R. Freire
Members of the NR4A subfamily of nuclear receptors have complex, overlapping roles during hematopoietic cell development and also function as tumor suppressors of hematologic malignancies. We previously identified NR4A1 and NR4A3 (NR4A1/3) as functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42228224ae759b89bbefc1c5ab4db205
https://europepmc.org/articles/PMC5863701/
https://europepmc.org/articles/PMC5863701/
Publikováno v:
Zootaxa. 2107:41-52
Fossil record of penaeids indicates that the family exists since the Triassic period, but extant genera appeared only recently in Tertiary strata. Molecular based divergence time estimates on the matter of penaeid radiation were never properly addres
Autor:
Se Hoon Kim, Dimpy Koul, W. K. Alfred Yung, Kenneth D. Aldape, Jonas S. Almeida, Agda Karina Lucio-Eterovic, Yong Wan Kim, Jing Wang, Pablo R. Freire, Jun Yao
Publikováno v:
Neuro-oncology. 15(7)
Glioblastomas (GBMs) are aggressive brain tumors for which there are few prognostic markers and predictors of therapeutic response.1–3 Although clinical and pathological subtype study of GBM has been increasing in recent years,4–6 identification
Autor:
Kenneth Aldape, Pablo R. Freire, W. K. Alfred Yung, Gordon B. Mills, Kevin R. Coombes, Marco Vilela, Oliver Bogler, Jonas S. Almeida, Howard Colman, Ana Tereza Ribeiro de Vasconcelos, Helena F. Deus, Dimpy Koul, Yong Wan Kim
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4076 (2008)
PLoS ONE
PLoS ONE
Background The Cancer Genome Atlas project (TCGA) has initiated the analysis of multiple samples of a variety of tumor types, starting with glioblastoma multiforme. The analytical methods encompass genomic and transcriptomic information, as well as d
Publikováno v:
Genetics and molecular research : GMR. 4(4)
Penaeid shrimps are an important resource in crustacean fisheries, representing more than the half of the gross production of shrimp worldwide. In the present study, we used a sample of wide-ranging diversity (41 shrimp species) and two mitochondrial