Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pablo R Sacasa"'
Autor:
Jennifer C Drew, Monika W Oli, Kelly C Rice, Alexandria N Ardissone, Sebastian Galindo-Gonzalez, Pablo R Sacasa, Heather J Belmont, Allen F Wysocki, Mark Rieger, Eric W Triplett
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0119548 (2015)
Although initial interest in science, technology, engineering and mathematics (STEM) is high, recruitment and retention remains a challenge, and some populations are disproportionately underrepresented in STEM fields. To address these challenges, the
Externí odkaz:
https://doaj.org/article/2753cd747de345cd92b16aa0a6939327
Autor:
Pablo R. Sacasa
OF THE DISSERTATION DEVELOPING OF GERMYLDESULFONYLATION AND THIODESULFONYLATION REACTIONS FOR THE SYNTHESIS OF NOVEL NUCLEOSIDE ANALOGUES. EFFICIENT SYNTHESIS OF NOVEL (α-FLUORO)VINYL SULFIDES. by Pablo R. Sacasa Florida International University, 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63e34b7cce8fe619a634292ba0c3bcd4
https://doi.org/10.25148/etd.fi10081201
https://doi.org/10.25148/etd.fi10081201
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 28:537-549
Treatment of the protected (E)-5'-deoxy-5'-[(p-toluenesulfonyl)methylene]uridine and adenosine derivatives with tributyl- or triphenylgermane hydride (AIBN/toluene/Delta) effected radical-mediated germyldesulfonylations to give 5'-(tributyl- or triph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b272041030a2f116d242dbd80982886
https://doi.org/10.1080/15257770903054340
https://doi.org/10.1080/15257770903054340
Autor:
Ronald T. Borchardt, Stanislaw F. Wnuk, Leigh N. Crain, Erik De Clercq, Elzbieta Lewandowska, Pablo R. Sacasa, Jinsong Zhang
Publikováno v:
Journal of Medicinal Chemistry. 47:5251-5257
Sonogashira coupling of (E)-6‘-iodohomovinyl nucleosides 1 with (trimethylsilyl)acetylene gave the conjugated 8‘-(trimethylsilyl)enyne derivatives of the adenosine 2a and uridine 2b with expected E-stereochemistry. Desilylation of 2a,b with tetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38e4ed3e925a785cd23cf28e42c1b90d
https://doi.org/10.1021/jm040054+
https://doi.org/10.1021/jm040054+
Autor:
Ronald T. Borchardt, Carlos A. Valdez, Bong-Oh Ro, Erik De Clercq, Stanislaw F. Wnuk, Pablo R. Sacasa, Neida X. Valdez, Dan Yin, Jinsong Zhang, Elzbieta Lewandowska
Publikováno v:
Journal of Medicinal Chemistry. 45:2651-2658
Moffatt oxidation of 2',3'-O-isopropylideneuridine (1a) and treatment of the crude 5'-aldehyde with formylmethylene-stabilized Wittig reagent gave the vinylogously extended 7'-aldehyde2a. Condensation of 2a with ethoxycarbonyl- or dibromomethylene ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9596fbc4fa88117be3ff14c2302944cc
https://doi.org/10.1021/jm020064f
https://doi.org/10.1021/jm020064f
Autor:
Sebastian Galindo-Gonzalez, Monika W. Oli, Heather J. Belmont, Alexandria N. Ardissone, Mark Rieger, Jennifer C. Drew, Allen F. Wysocki, Kelly C. Rice, Eric W. Triplett, Pablo R. Sacasa
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0119548 (2015)
PLoS ONE, Vol 10, Iss 4, p e0119548 (2015)
Although initial interest in science, technology, engineering and mathematics (STEM) is high, recruitment and retention remains a challenge, and some populations are disproportionately underrepresented in STEM fields. To address these challenges, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d70fc0f3ad0386045bda6db35a0f3ee
https://pubmed.ncbi.nlm.nih.gov/25875606
https://pubmed.ncbi.nlm.nih.gov/25875606
Autor:
Ronald T. Borchardt, Carlos A. Valdez, Pablo R. Sacasa, Bong-Oh Ro, Neida X. Valdez, Stanislaw F. Wnuk, Elzbieta Lewandowska, Jinsong Zhang, Erik De Clercq, Dan Yin
Publikováno v:
ChemInform. 33
Moffatt oxidation of 2',3'-O-isopropylideneuridine (1a) and treatment of the crude 5'-aldehyde with formylmethylene-stabilized Wittig reagent gave the vinylogously extended 7'-aldehyde2a. Condensation of 2a with ethoxycarbonyl- or dibromomethylene ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a609dbd3291a7c76c7245f8dea69223
https://doi.org/10.1002/chin.200238220
https://doi.org/10.1002/chin.200238220
Publikováno v:
ChemInform. 41
Treatment of the protected (E)-5′-deoxy-5′-[(p-toluenesulfonyl)methylene]uridine and adenosine derivatives with tributyl- or triphenylgermane hydride (AIBN/toluene/Δ) effected radical-mediated germyldesulfonylations to give 5′-(tributyl- or tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f2bcff52689ce33e6f6a7c8d795282
https://doi.org/10.1002/chin.201002213
https://doi.org/10.1002/chin.201002213
Publikováno v:
ChemInform. 40
Radical-mediated thiodesulfonylation of the vinyl and (α-fluoro)vinyl sulfones, derived from aldehydes and ketones, with aryl thiols in organic or aqueous medium provided access to vinyl and (α-fluoro)vinyl sulfides. The vinyl sulfides were formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059d2f1a69e12356702a7645ce1919f0
https://doi.org/10.1002/chin.200952096
https://doi.org/10.1002/chin.200952096
Radical-mediated thiodesulfonylation of the vinyl and (α-fluoro)vinyl sulfones, derived from aldehydes and ketones, with aryl thiols in organic or aqueous medium provided access to vinyl and (α-fluoro)vinyl sulfides. The vinyl sulfides were formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1183bc5b92fd776c272b236e11ab50
https://europepmc.org/articles/PMC2748331/
https://europepmc.org/articles/PMC2748331/