Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Pablo Penaloza-MacMaster"'
Autor:
Gabriel Arellano, Eric Acuña, Eileah Loda, Lindsay Moore, Juan E. Tichauer, Cristian Castillo, Fabian Vergara, Paula I. Burgos, Pablo Penaloza-MacMaster, Stephen D. Miller, Rodrigo Naves
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Cumulative evidence has established that Interferon (IFN)-γ has both pathogenic and protective roles in Multiple Sclerosis and the animal model, Experimental Autoimmune Encephalomyelitis (EAE). However, the underlying mechanisms to the bene
Externí odkaz:
https://doaj.org/article/7bd9295b9dc447cc99f375e5061ee3ef
Autor:
Lavanya Visvabharathy, Barbara A. Hanson, Zachary S. Orban, Patrick H. Lim, Nicole M. Palacio, Millenia Jimenez, Jeffrey R. Clark, Edith L. Graham, Eric M. Liotta, George Tachas, Pablo Penaloza-MacMaster, Igor J. Koralnik
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/87d9e70e1451439d8f6cb4686c6369ba
Autor:
Lavanya Visvabharathy, Barbara A. Hanson, Zachary S. Orban, Patrick H. Lim, Nicole M. Palacio, Millenia Jimenez, Jeffrey R. Clark, Edith L. Graham, Eric M. Liotta, George Tachas, Pablo Penaloza-MacMaster, Igor J. Koralnik
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMany people with long COVID symptoms suffer from debilitating neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro-PASC are widely documented, it is still unclear whether PASC symptoms impact vir
Externí odkaz:
https://doaj.org/article/7f1b637bb0e34dbf94d086e05a051b3c
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Within the inflammatory immune response to viral infection, the distribution and cell type-specific profiles of immune cell populations and the immune-mediated viral clearance pathways vary according to the specific virus. Uncovering th
Externí odkaz:
https://doaj.org/article/39c46221630844139b82af54c6727311
Autor:
Tanushree Dangi, Sarah Sanchez, Min Han Lew, Bakare Awakoaiye, Lavanya Visvabharathy, Justin M. Richner, Igor J. Koralnik, Pablo Penaloza-MacMaster
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112167- (2023)
Summary: mRNA vaccines are effective in preventing severe COVID-19, but breakthrough infections, emerging variants, and waning immunity warrant the use of boosters. Although mRNA boosters are being implemented, the extent to which pre-existing immuni
Externí odkaz:
https://doaj.org/article/7c8ddd98073c4f82ba7249389c71d584
Autor:
Tanushree Dangi, Sarah Sanchez, Jacob Class, Michelle Richner, Lavanya Visvabharathy, Young Rock Chung, Kirsten Bentley, Richard J. Stanton, Igor J. Koralnik, Justin M. Richner, Pablo Penaloza-MacMaster
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main antigen in all approved COVID-19 vaccines and is also the only target for monoclonal antibody (mAb) therapies. Immune responses to other viral antigens are gen
Externí odkaz:
https://doaj.org/article/c6f05bf9be5d495988ce89845a418e01
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored. To study the effect of B cell therapy, we adoptively transferred virus-specific B cells i
Externí odkaz:
https://doaj.org/article/946676fcb7fd4b0fb0a863dc50412bdd
Autor:
Xiaolei Cai, Min Chen, Aleksander Prominski, Yiliang Lin, Nicholas Ankenbruck, Jillian Rosenberg, Mindy Nguyen, Jiuyun Shi, Anastasia Tomatsidou, Glenn Randall, Dominique Missiakas, John Fung, Eugene B. Chang, Pablo Penaloza‐MacMaster, Bozhi Tian, Jun Huang
Publikováno v:
Advanced Science, Vol 9, Iss 2, Pp n/a-n/a (2022)
Abstract The outbreak of 2019 coronavirus disease (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has resulted in a global pandemic. Despite intensive research, the current treatment options show limited cura
Externí odkaz:
https://doaj.org/article/5a87e165b630476b9dfcd6664dc1a5eb
Autor:
Tobias Neef, Igal Ifergan, Sara Beddow, Pablo Penaloza-MacMaster, Kathryn Haskins, Lonnie D. Shea, Joseph R. Podojil, Stephen D. Miller
Publikováno v:
Cells, Vol 10, Iss 12, p 3445 (2021)
We have shown that PLG nanoparticles loaded with peptide antigen can reduce disease in animal models of autoimmunity and in a phase 1/2a clinical trial in celiac patients. Clarifying the mechanisms by which antigen-loaded nanoparticles establish tole
Externí odkaz:
https://doaj.org/article/4e8e07533efb4ca1b02b3300c04e13ab
Autor:
Yidan Wang, Young Rock Chung, Simon Eitzinger, Nicole Palacio, Shana Gregory, Mitra Bhattacharyya, Pablo Penaloza-MacMaster
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007583 (2019)
CD8 T cells are necessary for the elimination of intracellular pathogens, but during chronic viral infections, CD8 T cells become exhausted and unable to control the persistent infection. Programmed cell death-1 (PD-1) blockade therapies have been sh
Externí odkaz:
https://doaj.org/article/30237f5b3d054476a1436a4834bfd388