Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Pablo Pérez-Durán"'
Autor:
Arantxa Pérez‐García, Pablo Pérez‐Durán, Thomas Wossning, Isora V Sernandez, Sonia M Mur, Marta Cañamero, Francisco X Real, Almudena R Ramiro
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 10, Pp 1327-1336 (2015)
Abstract Activation‐induced deaminase (AID) initiates secondary antibody diversification in germinal center B cells, giving rise to higher affinity antibodies through somatic hypermutation (SHM) or to isotype‐switched antibodies through class swi
Externí odkaz:
https://doaj.org/article/f845f41e876b414eaa2cf320fdb7f77d
GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia
Autor:
Ramya Raviram, Clara Reglero, Francesco Gavino Brundu, Raul Rabadan, Pedro P. Rocha, Jose R. Cortes, Alexander Y. Yang, Daniel Herranz, S. Aidan Quinn, Jules P.P. Meijerink, Pablo Pérez-Durán, Valentina Cordo, Agnieszka A. Wendorff, Francesca Gianni, Silvia Alvarez, Marissa Rashkovan, Robert Albero, Adolfo A. Ferrando, Devya Gurung, Laura Belver, Anisha J. Cooke
Publikováno v:
Cancer Discovery. 9:1774-1791
Long-range enhancers govern the temporal and spatial control of gene expression; however, the mechanisms that regulate enhancer activity during normal and malignant development remain poorly understood. Here, we demonstrate a role for aberrant chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561896251e36b0020d1af41cb92deed0
https://doi.org/10.1158/2159-8290.cd-19-0471
https://doi.org/10.1158/2159-8290.cd-19-0471
Autor:
Martin S. Tallman, Junfei Zhao, Mignon L. Loh, Giuseppe Basso, Motohiro Kato, Meenakshi Devidas, Pablo Pérez-Durán, Timothy Chu, Julie M. Gastier-Foster, Maddalena Paganin, Alberto Ambesi-Impiombato, Katsuyoshi Koh, Zhengqiang Wang, Adolfo A. Ferrando, Laura Belver, Mark R. Litzow, Jessie A. Brown, Raul Rabadan, Concepcion Nicolas, Jules P.P. Meijerink, Elisabeth Paietta, Thomas Gunning, Aidan Quinn, Maria Luisa Sulis, Valeria Tosello, Juan Ángel Patiño-Galindo, Mark D. Minden, Jacob M. Rowe, Koichi Oshima, Milagros Balbín
Publikováno v:
Nat Cancer
Multiagent combination chemotherapy can be curative in acute lymphoblastic leukemia (ALL). Still, patients with primary refractory disease or with relapsed leukemia have a very poor prognosis. Here we integrate an in-depth dissection of the mutationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d235c8267fce444ac87f8ec6d3465fef
https://pubmed.ncbi.nlm.nih.gov/33796864
https://pubmed.ncbi.nlm.nih.gov/33796864
Autor:
Laura, Belver, Alexander Y, Yang, Robert, Albero, Daniel, Herranz, Francesco G, Brundu, S Aidan, Quinn, Pablo, Pérez-Durán, Silvia, Álvarez, Francesca, Gianni, Marissa, Rashkovan, Devya, Gurung, Pedro P, Rocha, Ramya, Raviram, Clara, Reglero, Jose R, Cortés, Anisha J, Cooke, Agnieszka A, Wendorff, Valentina, Cordó, Jules P, Meijerink, Raúl, Rabadan, Adolfo A, Ferrando
Publikováno v:
Cancer Discov
Long-range enhancers govern the temporal and spatial control of gene expression, however the mechanisms that regulate enhancer activity during normal and malignant development remain poorly understood. Here we demonstrate a role for aberrant chromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a32651d688d6d30ca15e6f36806c59a
https://pubmed.ncbi.nlm.nih.gov/31519704
https://pubmed.ncbi.nlm.nih.gov/31519704
Autor:
Alberto Benguria, Ángel F. Álvarez-Prado, Carlos Torroja, Pablo Pérez-Durán, Almudena R. Ramiro, Arantxa Pérez-García, Virginia G. de Yébenes
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
The Journal of Experimental Medicine
Instituto de Salud Carlos III (ISCIII)
The Journal of Experimental Medicine
Álvarez-Prado et al. report a detailed map of AID-induced off-target mutations and identify molecular features that predict gene mutability. They identify a novel AID hotspot and demonstrate that base excision and mismatch repair back up each other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8ffa466ca93d363095195e4b9d43c5
https://hdl.handle.net/20.500.12105/6545
https://hdl.handle.net/20.500.12105/6545
Autor:
Lauren M. Young, Dylan A. Reid, Eli Rothenberg, Domenico Roberti, Michele Pagano, Daniel N. Meredith, Ayelet Star, Antonio Marzio, Pablo Pérez-Durán, Beatrix Ueberheide
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 451-459 (2015)
Cell reports
Cell reports
SUMMARY PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22013a4a894b12c07d9b0f749cea5ad
Autor:
David G. Pisano, Pablo Pérez-Durán, Virginia G. de Yébenes, Almudena R. Ramiro, Pilar Delgado, Laura Belver
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine
UNG activity repairs activation-induced deaminase-generated U:G mismatches via error-prone or error-free repair, depending on the sequence context of the deaminated cytosine.
Secondary diversification of antibodies through somatic hypermutation
Secondary diversification of antibodies through somatic hypermutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c045557c89ead69662039c9a1dfa9c8
http://europepmc.org/articles/PMC3405504
http://europepmc.org/articles/PMC3405504
Autor:
Francesco Gavino Brundu, Alexander Y. Yang, Pedro P. Rocha, Devya Gurung, Adolfo A. Ferrando, Pablo Pérez-Durán, Raul Rabadan, Ramya Raviram, Marissa Rashkovan, Daniel Herranz, Laura Belver, Silvia Alvarez, Aidan Quinn
Publikováno v:
Blood. 132:545-545
Long range enhancers play critical roles in the control of gene expression during development and have emerged as key regulators of lineage commitment and oncogenic programs in hematopoiesis and leukemia. The MYC oncogene is dynamically regulated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd432e8236e03fc9ebdb52d5e5b5876a
https://doi.org/10.1182/blood-2018-99-119423
https://doi.org/10.1182/blood-2018-99-119423
Autor:
Marta Cañamero, Rubén Nogales-Cadenas, Almudena R. Ramiro, Nahikari Bartolomé-Izquierdo, Virginia G. de Yébenes, Miguel A. Piris, Nerea Martinez, Lorena Di Lisio, Pablo Pérez-Durán, Sonia M. Mur, Davide F. Robbiani, Alberto Pascual-Montano
Publikováno v:
Blood
microRNAs are a class of regulators of gene expression that have been shown critical for a great number of biological processes; however, little is known of their role in germinal center (GC) B cells. Although the GC reaction is crucial to ensure a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c314e3cef4c195fc9faaf2118ec4b17d
Publikováno v:
Europe PubMed Central
The generation of an efficient immune response depends on highly refined mechanisms of antibody diversification. Two of these mechanisms, somatic hypermutation (SHM) and class switch recombination (CSR), are initiated by activation-induced cytidine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2011488f9e343efa464bc4c473d6d0f0
https://pubmed.ncbi.nlm.nih.gov/17804422
https://pubmed.ncbi.nlm.nih.gov/17804422