Výsledky vyhledávání - "Pablo Nicolás de Francesco"

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Autor: Sonia Cantel, Pablo Nicolás de Francesco, Maia Uriarte, Gimena Fernandez, Vincent Prevot, Daniel Castrogiovanni, Séverine Denoyelle, Jean-Alain Fehrentz, Mario Perello, Micaela D'Arcangelo, Jeppe Praetorius, Monica Imbernon

Publikováno v: Uriarte, M, De Francesco, P N, Fernández, G, Castrogiovanni, D, D'Arcangelo, M, Imbernon, M, Cantel, S, Denoyelle, S, Fehrentz, J A, Praetorius, J, Prevot, V & Perello, M 2021, ' Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms ', Molecular and Cellular Endocrinology, vol. 538, 111449 . https://doi.org/10.1016/j.mce.2021.111449

Ghrelin is a peptide hormone mainly secreted from gastrointestinal tract that acts via the growth hormone secretagogue receptor (GHSR), which is highly expressed in the brain. Strikingly, the accessibility of ghrelin to the brain seems to be limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dcff22ede8f2ce0701db6a9b9a8bb5
https://pure.au.dk/portal/da/publications/circulating-ghrelin-crosses-the-bloodcerebrospinal-fluid-barrier-via-growth-hormone-secretagogue-receptor-dependent-and-independent-mechanisms(868ca3fa-1d36-4c76-b81d-173cf3d7698c).html

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Akademický článek

Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease

Autor: Natalia Cecilia Prymaczok, Pablo Nicolas De Francesco, Samanta Mazzetti, Marie Humbert-Claude, Liliane Tenenbaum, Graziella Cappelletti, Eliezer Masliah, Mario Perello, Roland Riek, Juan Atilio Gerez

Publikováno v: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)

Abstract Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous system. Lewy bodies can arise from the cell-to-cell propagation of αSyn, which can occur v

Externí odkaz: https://doaj.org/article/b475e19f60dc407d997399ffc8c7268c

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THE INTRIGUING LIGAND-DEPENDENT AND LIGAND-INDEPENDENT ACTIONS OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR ON REWARD-RELATED BEHAVIORS

Autor: Mario Perello, Pablo Nicolás de Francesco, Franco Barrile, Daniela Cassano, Emilio Román Mustafá, Jesica Raingo, María Paula Cornejo

Publikováno v: Neuroscience and biobehavioral reviews. 120

The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor (GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is evoked by the stomach-derived peptide hormone ghrelin and abrogated by the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a21102e0ecdab8a4b27ddc8a4d9c37
https://pubmed.ncbi.nlm.nih.gov/33157147

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Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region

Autor: Emilio Román Mustafá, Franco Barrile, Guadalupe García Romero, Sophie Mary, Céline M'Kadmi, Séverine Denoyelle, Pablo Nicolás de Francesco, Jacky Marie, Jesica Raingo, Sonia Cantel, Jean-Alain Fehrentz, Marjorie Damian, Jean Louis Banères, Agustina Cabral, Mario Perello

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2019, 498, pp.110573. ⟨10.1016/j.mce.2019.110573⟩

Liver-expressed antimicrobial peptide 2 (LEAP2) was recently recognized as an endogenous ligand for the growth hormone secretagogue receptor (GHSR), which also is a receptor for the hormone ghrelin. LEAP2 blocks ghrelin-induced activation of GHSR and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50301529834ba46d9c6fb0b01ddfbf6c
https://hal.archives-ouvertes.fr/hal-02375522

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Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: Correlation with age and insulin resistance

Autor: María F. Andreoli, Pablo Nicolás de Francesco, Adriana Fernández, J.M. Hernández, Daniela Lufrano, Daniel Castrogiovanni, María Victoria Fasano, Jean-Alain Fehrentz, Antonela Soledad Fittipaldi, Verónica Garrido, Patrick Vitaux, Mario Perello

Publikováno v: European Journal of Endocrinology
European Journal of Endocrinology, BioScientifica, In press, ⟨10.1530/EJE-19-0684⟩
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Objective: The octanoylated peptide hormone ghrelin regulates appetite and glycaemic control. Des-acyl ghrelin abolishes some effects of ghrelin, but does not bind to ghrelin receptor. LEAP2 is a novel ligand for ghrelin receptor that blocks the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe58c4acc00e29111ecb60b727fa830
https://eje.bioscientifica.com/view/journals/eje/aop/eje-19-0684/eje-19-0684.xml

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Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor-dependent manner

Autor: Gimena Fernandez, Mario Perello, Pablo Nicolás de Francesco, Gaston Diego Calfa, Agustina Cabral, Maria Jose Tolosa, Ángeles Rey Moggia

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 32, Iss, Pp 69-84 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Objective Arcuate nucleus (ARC) neurons producing Agouti-related peptide (AgRP) and neuropeptide Y (NPY; ARCAgRP/NPY neurons) are activated under energy-deficit states. ARCAgRP/NPY neurons innervate the hypothalamic paraventricular nucleus (PVH), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001a574d3c16bf7acd47424dbf2f63fa
https://pubmed.ncbi.nlm.nih.gov/32029231

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Rhinoxenus (Dactylogyridae) parasitizing piranhas (Serrasalmidae) at its southernmost limit of distribution (Paraná River, Argentina), with the description of two new species

Autor: Juan T. Timi, María Alejandra Rossin, Verónica Taglioretti, Pablo Nicolás de Francesco, Pablo Augusto Scarabotti, Manuel Marcial Irigoitia

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Anais da Academia Brasileira de Ciências, Volume: 91, Issue: 4, Article number: e20190711, Published: 02 DEC 2019
Anais da Academia Brasileira de Ciências v.91 n.4 2019
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Anais da Academia Brasileira de Ciências, Vol 91, Iss 4 (2019)

Three piranha species, Serrasalmus maculatus, S. marginatus and Pygocentrus nattereri, living sympatrically in the lower Parana River (Argentina) were examined searching for nasal monogeneans to know its diversity and distribution. Four species of mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016195a5a93b8e948e8b8908191d361
https://pubmed.ncbi.nlm.nih.gov/31800711

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Brain accessibility delineates the central effects of circulating ghrelin

Autor: Maia Uriarte, Gimena Fernandez, María Paula Cornejo, Pablo Nicolás de Francesco, Agustina Cabral, Mario Perello

Publikováno v: Journal of Neuroendocrinology. 31

Ghrelin is a hormone produced in the gastrointestinal tract that acts via the growth hormone secretagogue receptor. In the central nervous system, ghrelin signalling is able to recruit different neuronal targets that regulate the behavioural, neuroen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f118167358fe8e3cf14ab260990273c
https://doi.org/10.1111/jne.12677

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