Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Pablo Montañés"'
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Akademický článek
Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers
Autor: Auriane C. Ernault, Makiri Kawasaki, Benedetta Fabrizi, Pablo Montañés-Agudo, Shirley C. M. Amersfoorth, Rushd F. M. Al-Shama, Ruben Coronel, Joris R. De Groot
Publikováno v: Frontiers in Physiology, Vol 13 (2022)
Background: Atrial fibrosis plays an important role in the development and persistence of atrial fibrillation by promoting reentry. Primary cilia have been identified as a regulator of fibroblasts (FB) activation and extracellular matrix (ECM) deposi
Externí odkaz: https://doaj.org/article/ebebcfbda4be4769afb87a318b921dd0
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2
Akademický článek
Plk1 overexpression induces chromosomal instability and suppresses tumor development
Autor: Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocío Sotillo
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act
Externí odkaz: https://doaj.org/article/624e442f805148c5bac60f63e764f010
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3
Secretome of atrial epicardial adipose tissue facilitates reentrant arrhythmias by myocardial remodeling
Autor: Auriane C. Ernault, Arie O. Verkerk, Jason D. Bayer, Kedar Aras, Pablo Montañés-Agudo, Rajiv A. Mohan, Marieke Veldkamp, Mathilde R. Rivaud, Rosan de Winter, Makiri Kawasaki, Shirley C.M. van Amersfoorth, Eva R. Meulendijks, Antoine H.G. Driessen, Igor R. Efimov, Joris R. de Groot, Ruben Coronel
Publikováno v: Heart rhythm, 19(9), 1461-1470. Elsevier
Background: Epicardial adipose tissue (EAT) accumulation is associated with cardiac arrhythmias. The effect of EAT secretome (EATs) on cardiac electrophysiology remains largely unknown. Objective: The purpose of this study was to investigate the arrh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee2afabe8f87e36a8b16c0fbd1933b6
https://doi.org/10.1016/j.hrthm.2022.05.011
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4
Splicing factors in the heart: Uncovering shared and unique targets
Autor: Pablo Montañés-Agudo, Yigal M. Pinto, Esther E. Creemers
Publikováno v: Journal of molecular and cellular cardiology, 179, 72-79. Academic Press Inc.
Alternative splicing generates specialized protein isoforms that allow the heart to adapt during development and disease. The recent discovery that mutations in the splicing factor RNA-binding protein 20 (RBM20) cause a severe form of familial dilate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2f02de2b348fd195acbd039ec4b8e2
https://pure.amc.nl/en/publications/splicing-factors-in-the-heart(bcaef91f-bf13-4478-a2d4-f8bb8a48b4ed).html
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5
The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes
Autor: Pablo Montañés-Agudo, Simona Aufiero, Eva N Schepers, Ingeborg van der Made, Lucia Cócera-Ortega, Auriane C Ernault, Stéphane Richard, Diederik W D Kuster, Vincent M Christoffels, Yigal M Pinto, Esther E Creemers
Publikováno v: Cardiovascular research, 119(5), 1161-1174. Oxford University Press
Montañés-Agudo, P, Aufiero, S, Schepers, E N, van der Made, I, Cócera-Ortega, L, Ernault, A C, Richard, S, Kuster, D W D, Christoffels, V M, Pinto, Y M & Creemers, E E 2023, ' The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes ', Cardiovascular Research, vol. 119, no. 5, pp. 1161-1174 . https://doi.org/10.1093/cvr/cvad007
Cardiovascular Research, 119(5), 1161-1174. Oxford University Press
Aims In the heart, splicing factors orchestrate the functional properties of cardiomyocytes by regulating the alternative splicing of multiple genes. Work in embryonic stem cells has shown that the splicing factor Quaking (QKI) regulates alternative
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50ebc788e68dadde46220d5ca49892c
https://pure.amc.nl/en/publications/the-rnabinding-protein-qki-governs-a-musclespecific-alternative-splicing-program-that-shapes-the-contractile-function-of-cardiomyocytes(48df7777-6df4-415c-856b-d4c9b3858e67).html
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9
Inhibition of minor intron splicing reduces Na+ and Ca2+ channel expression and function in cardiomyocytes
Autor: Auriane C Ernault, Ingeborg van der Made, Simona Casini, Simona Aufiero, Pablo Montañés-Agudo, Carol Ann Remme, Yigal M. Pinto, Esther E. Creemers
Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science, 135(1):jcs259191. Company of Biologists Ltd
Eukaryotic genomes contain a tiny subset of ‘minor class’ introns with unique sequence elements that require their own splicing machinery. These minor introns are present in certain gene families with specific functions, such as voltage-gated Na+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d72f7abfae575d196f3a28d5755a17
http://www.scopus.com/inward/record.url?scp=85123376557&partnerID=8YFLogxK
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Plný text Recenzováno Digitální knihovna AV ČR
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