Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Pablo M. Linares"'
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Akademický článek
Endothelial MT1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis
Autor: Sergio Esteban, Cristina Clemente, Agnieszka Koziol, Pilar Gonzalo, Cristina Rius, Fernando Martínez, Pablo M Linares, María Chaparro, Ana Urzainqui, Vicente Andrés, Motoharu Seiki, Javier P Gisbert, Alicia G Arroyo
Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-22 (2019)
Abstract Pathological angiogenesis contributes to cancer progression and chronic inflammatory diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive angiogenesis (IA), a poorly characterized mechanism involving incre
Externí odkaz: https://doaj.org/article/9afa1d17714c4eba8342c3b1e489a00e
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2
Endothelial MT1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis
Autor: María Chaparro, Pilar Gonzalo, Agnieszka Koziol, Fernando Martínez, Ana Urzainqui, Javier P. Gisbert, Vicente Andrés, Alicia G. Arroyo, Pablo M. Linares, Cristina Clemente, Sergio Esteban, Motoharu Seiki, Cristina Rius
Publikováno v: EMBO Molecular Medicine
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
22 p.-9 fig.
Pathological angiogenesis contributes to cancer progression and chronic inflammatory diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive angiogenesis (IA), a poorly characterized mechanism involv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75185155c26116c42bd03050622edbd
http://europepmc.org/articles/PMC7005619
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3
Ratio of Circulating Estrogen Receptors Beta and Alpha (ERβ/ERα) Indicates Endoscopic Activity in Patients with Crohn’s Disease
Autor: Iván Guerra, Fernando Bermejo, Ana Urzainqui, Jesús Garrido, Pablo M. Linares, Mercedes Guijarro-Rojas, Víctor M Castellano, Rafael González-Tajuelo, María Chaparro, Alicia Algaba, María-Encarnación Fernández-Contreras, Javier P. Gisbert
Publikováno v: Digestive Diseases and Sciences. 62:2744-2754
Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammato
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c2323c32a45f0bc032fa161c09a8c9
https://doi.org/10.1007/s10620-017-4717-5
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4
Effect of Chondroitin Sulphate on Pro-Inflammatory Mediators and Disease Activity in Patients with Inflammatory Bowel Disease
Autor: Iván Guerra, Dolores Ochoa, F. Abad Santos, Fernando Bermejo, I. Moreno Arza, Javier P. Gisbert, María Chaparro, Alicia Algaba, Manuel Román, Pablo M. Linares
Publikováno v: Digestion. 92:203-210
Background/Aims: To evaluate the incidence rate of relapse in patients with inflammatory bowel disease (IBD) undergoing chondroitin sulphate (CS) treatment and its effect on the concentrations of several pro-inflammatory proteins. Methods: Prospectiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be8c4af3b9ae16e07f0451a5d1ffc2b
https://doi.org/10.1159/000439522
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5
The Effects of Infliximab or Adalimumab on Vascular Endothelial Growth Factor and Angiopoietin 1 Angiogenic Factor Levels in Inflammatory Bowel Disease
Autor: Alicia Algaba, Fernando Bermejo, Xavier Calvet, Javier P. Gisbert, I. D. Pousa, Ariadna Figuerola, Iván Guerra, M. Encarnación Fernández-Contreras, María Chaparro, Pablo M. Linares
Publikováno v: Inflammatory Bowel Diseases. 20:695-702
BACKGROUND Infliximab and adalimumab effectiveness might be related with changes in angiogenic factors. The aim of the study was to compare the concentrations of angiogenic proteins in patients with inflammatory bowel disease (IBD) and healthy contro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b67cc4720137cfdc7d7fa681b365a31
https://doi.org/10.1097/mib.0000000000000004
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6
Angiopoietins in inflammation and their implication in the development of inflammatory bowel disease. A review
Autor: Javier P. Gisbert, Pablo M. Linares, María Chaparro
Publikováno v: Journal of Crohn's and Colitis. 8:183-190
Background Angiopoietins are essential angiogenic mediators. Since inflammatory bowel disease (IBD) involves inflammation, ulceration and regeneration of the intestinal mucosa, the angiopoietin system has been proposed as a factor to maintain patholo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfc6778cbbdac67fb288eff8a4d9932
https://doi.org/10.1016/j.crohns.2013.06.013
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Role of growth factors in the development of lymphangiogenesis driven by inflammatory bowel disease
Autor: Pablo M. Linares, Javier P. Gisbert
Publikováno v: Inflammatory Bowel Diseases. 17:1814-1821
Studies on angiogenesis and lymphangiogenesis have gained special relevance in research into factors potentially influencing the pathogenesis and course of inflammatory bowel disease (IBD). The results of the few existing studies on the distribution
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d371cce12e46419228f64c5b8fcb0ede
https://doi.org/10.1002/ibd.21554
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8
Outcomes of Pregnancies Fathered by Inflammatory Bowel Disease Patients Exposed to Thiopurines
Autor: Pilar López-Serrano, Antonio Roman, Alfonso Muriel, Jesús Estellés, Ángel Ponferrada, Pablo M. Linares, Carlos Teruel, José Lázaro Pérez-Calle, Javier P. Gisbert, Alicia Algaba, Carlos Taxonera, Manuel Van Domselaar, Fernando Bermejo, María Dolores Martín-Arranz
Publikováno v: American Journal of Gastroenterology. 105:2003-2008
Immunomodulators are used as maintenance treatment of inflammatory bowel disease (IBD). Data regarding their possible effects in the course of pregnancy when the father is exposed at the time of conception are limited.To evaluate the outcomes of preg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f55e8409becbbe3ae60ee5ba349e66
https://doi.org/10.1038/ajg.2010.138
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9
Corticosteroids Modulate Angiogenic Soluble Factors in Ulcerative Colitis Patients
Autor: Javier P. Gisbert, Paloma Sanz-Cameno, Pablo M. Linares, I. D. Pousa, Fernando Bermejo, Alicia Algaba, Jose Luis Mate, Ricardo Moreno-Otero
Publikováno v: Digestive Diseases and Sciences. 56:871-879
The aim of this study was to compare angiogenic factors in serum levels of active ulcerative colitis (UC) patients and in healthy controls, and to analyze these angiogenic levels depending on the achievement of remission after oral corticosteroid tre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40dd33a999e496cca3f928479d37e33
https://doi.org/10.1007/s10620-010-1327-x
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10
Meta-analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis
Autor: Adrian G. McNicholl, Javier P. Gisbert, Fernando Gomollón, Pablo M. Linares, J. Maté
Publikováno v: Alimentary Pharmacology & Therapeutics. 30:126-137
Summary Background Debate exists regarding to whether thiopurine therapy is as effective in ulcerative colitis (UC) as it is in Crohn's disease. Aim To review systematically the efficacy of azathioprine (AZA) and mercaptopurine (MP) in UC, and to con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fbfc19249d06e46eb2e2753a13c307d
https://doi.org/10.1111/j.1365-2036.2009.04023.x
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