Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Pablo M. Casillas Espinosa"'
Autor:
Rishabh Sharma, Wai Lam Leung, Akram Zamani, Terence J. O’Brien, Pablo M. Casillas Espinosa, Bridgette D. Semple
Publikováno v:
Brain Sciences, Vol 9, Iss 11, p 318 (2019)
Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug-resistant in at least one-third of patients, there is a clear need for
Externí odkaz:
https://doaj.org/article/471cc09fcdad435c871236fc8be4b8e2
Autor:
Glenn R. Yamakawa, Meshwa Patel, Runxuan Lin, Terence J. O'Brien, Richelle Mychasiuk, Pablo M. Casillas‐Espinosa
Publikováno v:
Epilepsia Open, Vol 8, Iss 4, Pp 1523-1531 (2023)
Abstract Objectives Growing evidence demonstrates a relationship between epilepsy and the circadian system. However, relatively little is known about circadian function in disease states, such as epilepsy. This study aimed to characterize brain and p
Externí odkaz:
https://doaj.org/article/b09075573573429ab4e896b4a16c581d
Autor:
Patricia G. Saletti, Wenzhu B. Mowrey, Wei Liu, Qianyun Li, Jesse McCullough, Roxanne Aniceto, I‐Hsuan Lin, Michael Eklund, Pablo M. Casillas‐Espinosa, Idrish Ali, Cesar Santana‐Gomez, Lisa Coles, Sandy R. Shultz, Nigel Jones, Richard Staba, Terence J. O'Brien, Solomon L. Moshé, Denes V. Agoston, Aristea S. Galanopoulou, for the EpiBioS4Rx Study Group
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 586-608 (2023)
Abstract Objective We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post‐traumatic seizures or neuromotor functional recover
Externí odkaz:
https://doaj.org/article/0fa6ea6ae33d4d8783473bb3574a6e08
Autor:
Zining Liu, Peravina Thergarajan, Ana Antonic‐Baker, Zhibin Chen, Paul B. Sparks, Natasha A. Lannin, Patrick Kwan, Nigel C. Jones, Pablo M. Casillas‐Espinosa, Piero Perucca, Terence J. O'Brien, Shobi Sivathamboo
Publikováno v:
Epilepsia Open, Vol 8, Iss 1, Pp 46-59 (2023)
Abstract Objective Epilepsy is associated with an increased risk of cardiovascular disease and mortality. Whether cardiac structure and function are altered in epilepsy remains unclear. To address this, we conducted a systematic review and meta‐ana
Externí odkaz:
https://doaj.org/article/41d28ae52732432281edd50736966a1d
Autor:
Pablo M. Casillas-Espinosa, Runxuan Lin, Rui Li, Nanditha M. Nandakumar, Georgia Dawson, Emma L. Braine, Benoît Martin, Kim L. Powell, Terence J. O'Brien
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106217- (2023)
Rationale: Low-voltage-activated or T-type Ca2+ channels play a key role in the generation of seizures in absence epilepsy. We have described a homozygous, gain of function substitution mutation (R1584P) in the CaV3.2 T-type Ca2+ channel gene (Cacna1
Externí odkaz:
https://doaj.org/article/b0a167a094254b4caaf3662017799fba
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
Publikováno v:
eLife, Vol 12 (2023)
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of sodium sel
Externí odkaz:
https://doaj.org/article/4e8722171a41474ebb674b4e800efafa
Autor:
Kim L. Powell, Zining Liu, Claire L. Curl, Antonia J.A. Raaijmakers, Pragati Sharma, Emma L. Braine, Flavia M. Gomes, Shobi Sivathamboo, Vaughan G. Macefield, Pablo M. Casillas-Espinosa, Nigel C. Jones, Lea M. Delbridge, Terence J. O’Brien
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105505- (2021)
Objective: This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic acquired temporal lobe epilepsy (TLE), specifically to examine for changes between th
Externí odkaz:
https://doaj.org/article/2f278a222be74d4a903bacd65e7a477e
Autor:
Patricia G. Saletti, Idrish Ali, Pablo M. Casillas-Espinosa, Bridgette D. Semple, Christos Panagiotis Lisgaras, Solomon L. Moshé, Aristea S. Galanopoulou
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 86-99 (2019)
Post-traumatic epilepsy (PTE) is diagnosed in 20% of individuals with acquired epilepsy, and can impact significantly the quality of life due to the seizures and other functional or cognitive and behavioral outcomes of the traumatic brain injury (TBI
Externí odkaz:
https://doaj.org/article/befb89fe79c14fd7b707fccd4ff52fc2
Autor:
Rhys D. Brady, Pablo M. Casillas-Espinosa, Denes V. Agoston, Edward H. Bertram, Alaa Kamnaksh, Bridgette D. Semple, Sandy R. Shultz
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 8-19 (2019)
Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human p
Externí odkaz:
https://doaj.org/article/040d54ea0a0248159b467b6e2ac74915
Autor:
Anna Harutyunyan, Debbie Chong, Rui Li, Anup D. Shah, Zahra Ali, Cheng Huang, Christopher K. Barlow, Piero Perucca, Terence J. O’Brien, Nigel C. Jones, Ralf B. Schittenhelm, Alison Anderson, Pablo M. Casillas-Espinosa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6063 (2022)
Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, although a polygenic architecture is presumed. Current focus on single molecule or gene identification to elucidate epilep
Externí odkaz:
https://doaj.org/article/f97e819b694a4e54817e1b21a02300b1