Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Pablo M Paez"'
Autor:
Araceli Espinosa-Jeffrey, Pablo M Paez, Veronica T Cheli, Vilma Spreuer, Ina Wanner, Jean de Vellis
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e76963 (2013)
We have recently established a culture system to study the impact of simulated microgravity on oligodendrocyte progenitor cells (OPCs) development. We subjected mouse and human OPCs to a short exposure of simulated microgravity produced by a 3D-Clino
Externí odkaz:
https://doaj.org/article/ece039879a234d5bb307b55af9bec7ab
Publikováno v:
ASN Neuro, Vol 2 (2009)
It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′, 3′-cyclic nucle
Externí odkaz:
https://doaj.org/article/637ee98386344366910eb84d8dd737c1
Autor:
Pablo M Paez, Daniel J Fulton, Vilma Spreuer, Vance Handley, Celia W Campagnoni, Anthony T Campagnoni
Publikováno v:
ASN Neuro, Vol 1 (2009)
OPCs (oligodendrocyte precursor cells) express golli proteins which, through regulation of Ca 2+ influx, appear to be important in OPC process extension/retraction and migration. The aim of the present study was to examine further the role of golli i
Externí odkaz:
https://doaj.org/article/a45df08d017f434a81ff7447389a35b2
Autor:
Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein
Publikováno v:
ASN Neuro, Vol 14 (2022)
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage. Previous studies showed that lanthionine ketenamine ethyl ester (LKE) reduc
Externí odkaz:
https://doaj.org/article/3641087f2b974803ace5d745e6ad5564
Autor:
Pablo M. Paez, Veronica T. Cheli, Rensheng Wan, Shaina L. Rosenblum, Qiuchen Wan, Diara A. Santiago-González
Publikováno v:
J Neurosci
To define the importance of iron storage in oligodendrocyte development and function, the ferritin heavy subunit (Fth) was specifically deleted in oligodendroglial cells. Blocking Fth synthesis in Sox10 or NG2-positive oligodendrocytes during the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e231302166cfd9ffce86bca20b494d
https://doi.org/10.1523/jneurosci.1281-20.2020
https://doi.org/10.1523/jneurosci.1281-20.2020
Publikováno v:
J Neurosci
To determine whether Cav1.2 voltage-gated Ca2+channels contribute to astrocyte activation, we generated an inducible conditional knock-out mouse in which the Cav1.2 α subunit was deleted in GFAP-positive astrocytes. This astrocytic Cav1.2 knock-out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e704932981a0979fd8241fe74deb404e
https://doi.org/10.1523/jneurosci.1644-19.2020
https://doi.org/10.1523/jneurosci.1644-19.2020
Publikováno v:
Redox Biology
Redox Biology, Vol 46, Iss, Pp 102118-(2021)
Redox Biology, Vol 46, Iss, Pp 102118-(2021)
Ceruloplasmin (Cp) is a ferroxidase enzyme that is essential for cell iron efflux and has been postulated to have a neuroprotective role. During the myelination process, oligodendrocytes (OLs) and Schwann cells (SCs) express high levels of Cp, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fba72f690f83888388ea8e23971924
https://pubmed.ncbi.nlm.nih.gov/34474395
https://pubmed.ncbi.nlm.nih.gov/34474395
Publikováno v:
J Neurosci
Iron is an essential cofactor for many cellular enzymes involved in myelin synthesis, and iron homeostasis unbalance is a central component of peripheral neuropathies. However, iron absorption and management in the PNS are poorly understood. To study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39b80efee1acab2ee6f449fae2f9ecb
https://doi.org/10.1523/jneurosci.1409-19.2019
https://doi.org/10.1523/jneurosci.1409-19.2019
Autor:
Mariapaola Sidoli, M. Laura Feltri, Chelsey B. Reed, Cristina Scapin, Pablo M. Paez, Randal J. Kaufman, Maurizio D'Antonio, Douglas R. Cavener, Lawrence Wrabetz
Publikováno v:
J Neurosci
Schwann cells produce a considerable amount of lipids and proteins to form myelin in the PNS. For this reason, the quality control of myelin proteins is crucial to ensure proper myelin synthesis. Deletion of serine 63 from P0 (P0S63del) protein in my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee5e3ce1df07bd861f3418a822c20e5
https://pubmed.ncbi.nlm.nih.gov/33879538
https://pubmed.ncbi.nlm.nih.gov/33879538
Publikováno v:
ASN Neuro, Vol 12 (2020)
ASN NEURO
ASN NEURO
Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron excess may result in harmful effects in the CNS. Oligodendrocytes and astrocytes are crucial players in brain iron equilibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded43d8da0ec0fb743a8fc60dd130d39
https://doaj.org/article/e689bab1393a4e4781a5a50e085e7d3e
https://doaj.org/article/e689bab1393a4e4781a5a50e085e7d3e