Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Pablo Lorenzano Menna"'
Autor:
Nazareno González, Georgina A. Cardama, Patricio Chinestrad, Javier Robles-Valero, Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Xosé R. Bustelo, Pablo Lorenzano Menna, Daniel E. Gomez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that
Externí odkaz:
https://doaj.org/article/f2d956e6c0694d8b9d53c1dc93810789
Autor:
Laura Lucía Trebucq, Georgina Alexandra Cardama, Pablo Lorenzano Menna, Diego Andrés Golombek, Juan José Chiesa, Luciano Marpegan
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1091 (2021)
The Ras homologous family of small guanosine triphosphate-binding enzymes (GTPases) is critical for cell migration and proliferation. The novel drug 1A-116 blocks the interaction site of the Ras-related C3 botulinum toxin substrate 1 (RAC1) GTPase wi
Externí odkaz:
https://doaj.org/article/8ffd49b9073b41ae8fb5b2e53f8e8aec
Autor:
Romina Gabriela Armando, Diego Luis Mengual Gómez, Ezequiel Ivan Juritz, Pablo Lorenzano Menna, Daniel Eduardo Gomez
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3216 (2018)
Immortality is one of the main features of cancer cells. Tumor cells have an unlimited replicative potential, principally due to the holoenzyme telomerase. Telomerase is composed mainly by dyskerin (DKC1), a catalytic retrotranscriptase (hTERT) and a
Externí odkaz:
https://doaj.org/article/27363e3377ba4e598b144f6795b7adb0
Autor:
Romina Armando, Maia Cabrera, Roman Vilarullo, Patricio Chinestrad, Julian Maggio, Camila Paderta, Pablo Lorenzano Menna, Daniel Gomez, Diego Mengual Gómez
Publikováno v:
Oncology Reports. 48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c6096086d96d3012efdfce67a24581
https://doi.org/10.3892/or.2022.8403
https://doi.org/10.3892/or.2022.8403
Autor:
Julian Maggio, Maia Diana Eliana Cabrera, Patricio Chinestrad, Pablo Lorenzano Menna, Daniel E. Gomez, Diego Luis Mengual Gómez, Romina Gabriela Armando, Marina Pifano
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:5858-5867
The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs. PIN1 binds to a subset of proteins and plays an essential role in regulating pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd23a2fed5204af0e1c8a1317abdb3ad
https://doi.org/10.1080/07391102.2021.1874531
https://doi.org/10.1080/07391102.2021.1874531
Autor:
Pablo Lorenzano Menna, Martina Bevilacqua, Mariane Gonçalves Kulik, Alexander Miguel Monzon, Lisanna Paladin, José Luis López, Martin Gonzalez Buitron, Javier Rios, Marco Necci, Sara Errigo, Layla Hirsh, Ivan Mičetić, Juliet F. Nilsson, Andrey V. Kajava, María Silvina Fornasari, Antonio Lagares, Damiano Piovesan, Sebastian Fernandez-Alberti, Maia Diana Eliana Cabrera, Gustavo Parisi, María Laura Fabre, Miguel A. Andrade-Navarro, Silvio C. E. Tosatto
Publikováno v:
Nucleic Acids Research
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa1097⟩
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa1097⟩
The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life. The accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588bf86faec4b1890cf5cf27d81eb86a
http://europepmc.org/articles/PMC7778985
http://europepmc.org/articles/PMC7778985
Autor:
Paula Maloberti, María T. Torres, Facundo José Salinas, Natalia Raquel Salvetti, Pablo Lorenzano Menna, Graciela Caroca, Daniel E. Gomez, Ulises Daniel Orlando, María Mercedes Bigi, Hugo Hector Ortega, Jesica Giselle Prada, Ana Fernanda Castillo, Juan B. Rodriguez, Angela Rosario Solano, Melina Andrea Dattilo, Belkis Ester Marelli, Mayra Agustina Ríos Medrano, Ernesto J. Podestá, Sebastián Indo, Sergio H. Szajnman, Héctor R. Contreras
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved in the development of tumor aggressiveness in breast and prostate tumors throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39674d4ecf3f1fcea02ce8833b25ddb
https://doi.org/10.1007/s00018-020-03679-5
https://doi.org/10.1007/s00018-020-03679-5
Autor:
Miguel A. Pavón, Sonia Zumalave, Myriam Cuadrado, Antonio Abad, Carmen Segrelles, Xosé R. Bustelo, Gloria Pascual, Natalia Fernández-Parejo, María C. García-Macías, Salvador Aznar Benitah, Rogelio González-Sarmiento, Salvatore Fabbiano, Juan P. Rodrigo, Sonia Rodríguez-Fdez, Nazareno González, Mauricio Menacho-Márquez, L. Francisco Lorenzo-Martín, Javier Robles-Valero, Juana M. García-Pedrero, Pablo Lorenzano-Menna, Jesús M. Paramio, Jose M. C. Tubio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
© The Author(s) 2020.
Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-
Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f9e862d0c51daed5c4d0a59fb3a9f7
https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c
https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c
Preclinical Efficacy and Toxicology Evaluation of RAC1 Inhibitor 1A-116 in Human Glioblastoma Models
Autor:
Georgina A. Cardama, Julian Maggio, Lucas Valdez Capuccino, Nazareno Gonzalez, Valentina Matiller, Hugo H. Ortega, German R. Perez, Ignacio A. Demarco, Eduardo Spitzer, Daniel E. Gomez, Pablo Lorenzano Menna, Daniel F. Alonso
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4810
Malignant gliomas are the most common primary central nervous system tumor in adults. Despite current therapeutics, these tumors are associated with poor prognosis and a median survival of 16 to 19 months. This highlights the need for innovative trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b867e11cecc8e1336a18f1ef060382
https://doi.org/10.3390/cancers14194810
https://doi.org/10.3390/cancers14194810
Publikováno v:
2020 IEEE Congreso Bienal de Argentina (ARGENCON).
This work presents an interdisciplinary end-to-end development applied to the computer-based rational design of drugs, in a context of heterogeneous high-performance computing. For that end it integrates the ARM big.LITTLE and Intel/AMD x64 architect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d43eafda6c8c72f0a841945912ed6f
https://doi.org/10.1109/argencon49523.2020.9505328
https://doi.org/10.1109/argencon49523.2020.9505328