Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pablo Lazcano"'
Autor:
Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke, Pablo Lazcano, Simone W. Denis, Mária Balážová, Nevton Teixeira da Rosa, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H. Houtkooper, Miriam L. Greenberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Barth syndrome (BTHS) is a rare disorder caused by mutations in the TAFAZZIN gene. Previous studies from both patients and model systems have established metabolic dysregulation as a core component of BTHS pathology. In particular, features
Externí odkaz:
https://doaj.org/article/0764c46ec838464c99b44c7af0e10035
Autor:
Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke, Pablo Lazcano, Simone W. Denis, Mária Balážová, Nevton Teixeira da Rosa, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H. Houtkooper, Miriam L. Greenberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/69d323fe70974129940cd583a5da7ab1
TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons
Autor:
Rodrigo Sandoval, Pablo Lazcano, Franco Ferrari, Nicolás Pinto-Pardo, Christian González-Billault, Elías Utreras
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. We reported earlier a key
Externí odkaz:
https://doaj.org/article/87065accbdb349418e48df58e3cf4f5f
Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::601c2bdd5c586c2fc9ae3403222c71eb
https://doi.org/10.1101/2022.02.21.481348
https://doi.org/10.1101/2022.02.21.481348
Publikováno v:
Journal of Biological Chemistry. 298:102363
Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff25ea2534b89d3f6811727f4b2b29fa
https://doi.org/10.1016/j.jbc.2022.102363
https://doi.org/10.1016/j.jbc.2022.102363
Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells
Autor:
Mahmoud Suliman, Kendall C. Case, Michael W. Schmidtke, Pablo Lazcano, Chisom J. Onu, Miriam L. Greenberg
Publikováno v:
Biochim Biophys Acta Mol Cell Biol Lipids
Inositol plays a significant role in cellular function and signaling. Studies in yeast have demonstrated an “inositol-less death” phenotype, suggesting that inositol is an essential metabolite. In yeast, inositol synthesis is highly regulated, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f96072b5dfc3f1e8ded511f4ee7ac1
https://doi.org/10.1016/j.bbalip.2022.159137
https://doi.org/10.1016/j.bbalip.2022.159137
Autor:
Maureen Tarsio, Michael W. Schmidtke, Pablo Lazcano, Patricia M. Kane, Michael Salsaa, Miriam L. Greenberg, Christian A. Reynolds, Kerestin Aziz, Maik Hüttemann
Publikováno v:
The Journal of biological chemistry. 297(4)
Valproate (VPA) is a widely used mood stabilizer, but its therapeutic mechanism of action is not understood. This knowledge gap hinders the development of more effective drugs with fewer side effects. Using the yeast model to elucidate the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0e5083a9dc67c2eef9dbc0015887d3
https://pubmed.ncbi.nlm.nih.gov/34428448
https://pubmed.ncbi.nlm.nih.gov/34428448
Autor:
Jiajia Ji, Deena Damschroder, Denise Bessert, Pablo Lazcano, Robert Wessells, Christian A. Reynolds, Miriam L. Greenberg
Publikováno v:
Biochim Biophys Acta Mol Cell Biol Lipids
Cardiolipin (CL) deficiency causes mitochondrial dysfunction and aberrant metabolism that are associated in humans with the severe disease Barth syndrome (BTHS). Several metabolic abnormalities are observed in BTHS patients and model systems, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24918bb78377fad86d3b4fc488998d91
https://doi.org/10.1016/j.bbalip.2021.159094
https://doi.org/10.1016/j.bbalip.2021.159094
Autor:
Rodrigo Sandoval, Bradford Hall, Elias Utreras, Patricio A. Castro, Stanko S. Stojilkovic, Ashok B. Kulkarni, Christian Gonzalez-Billault, Anita Terse, Milos B. Rokic, Pablo Lazcano, Claudio Coddou, María José Hevia
Publikováno v:
Pain
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (TPKH), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fb12dc4fe5e866389b17b689281aae
https://doi.org/10.1097/j.pain.0000000000001021
https://doi.org/10.1097/j.pain.0000000000001021
Autor:
Yiran Li, Vaishnavi Raja, Smiti V. Gupta, Pablo Lazcano, Amit S. Joshi, Miriam L. Greenberg, Michael W. Schmidtke, Michael Salsaa, Ronald J.A. Wanders, Nadia Saadat, Carlo W.T. van Roermund, Maik Hüttemann
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1864(8)
The authors regret to report an error in Table 1 of this publication. The mating type of yeast strain BY4741 should have been listed as MATa rather than MATα as printed. All additional information in this table is correct. The authors would like to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb457987b296c9cc0605f5e543bda3ed
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064994195&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064994195&origin=inward