Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Pablo Lara-Gonzalez"'
Autor:
Laura Bel Borja, Flavie Soubigou, Samuel J P Taylor, Conchita Fraguas Bringas, Jacqueline Budrewicz, Pablo Lara-Gonzalez, Christopher G Sorensen Turpin, Joshua N Bembenek, Dhanya K Cheerambathur, Federico Pelisch
Publikováno v:
eLife, Vol 9 (2020)
Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore–
Externí odkaz:
https://doaj.org/article/46c49bf47cba45a7810f3a56ede9e085
Autor:
Julien Espeut, Pablo Lara-Gonzalez, Mélanie Sassine, Andrew K. Shiau, Arshad Desai, Ariane Abrieu
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 58-65 (2015)
The spindle checkpoint safeguards against chromosome loss during cell division by preventing anaphase onset until all chromosomes are attached to spindle microtubules. Checkpoint signal is generated at kinetochores, the primary attachment site on chr
Externí odkaz:
https://doaj.org/article/fc73bbd3d699428ca29316d41833a503
Autor:
Pablo Lara-Gonzalez, Stephen S Taylor
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49041 (2012)
The Spindle Assembly Checkpoint (SAC) delays the onset of anaphase in response to unattached kinetochores by inhibiting the activity of the Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. Once all the chromosomes have bioriented
Externí odkaz:
https://doaj.org/article/776ae346698449ae94ece13fb2c650b0
Autor:
Jack Houston, Midori Ohta, J. Sebastián Gómez-Cavazos, Amar Deep, Kevin D. Corbett, Karen Oegema, Pablo Lara-Gonzalez, Taekyung Kim, Arshad Desai
Publikováno v:
Current Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ba77c0aea0ef22196917e527818397
https://doi.org/10.1016/j.cub.2023.04.021
https://doi.org/10.1016/j.cub.2023.04.021
Autor:
Helder Rocha, Patrícia A. Simões, Jacqueline Budrewicz, Pablo Lara-Gonzalez, Ana Xavier Carvalho, Julien Dumont, Arshad Desai, Reto Gassmann
Publikováno v:
Journal of Cell Biology. 222
A landmark event in the transition from interphase to mitosis in metazoans is nuclear envelope breakdown (NEBD). Many events important for mitosis occur prior to NEBD, including condensation of replicated chromosomes and assembly of kinetochores to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a56de3597c7b9fee68e2bb1017d7e87
https://doi.org/10.1083/jcb.202208154
https://doi.org/10.1083/jcb.202208154
Autor:
Lu Wang, Caleb Heffner, Keng loi Vong, Chelsea Barrows, Yoo-Jin Ha, Sangmoon Lee, Pablo Lara-Gonzalez, Ishani Jhamb, Dennis Van Der Meer, Robert Loughnan, Nadine Parker, David Sievert, Swapnil Mittal, Mahmoud Y. Issa, Ole A. Andreassen, Anders Dale, William B. Dobyns, Maha S. Zaki, Stephen A. Murray, Joseph G. Gleeson
Publikováno v:
Proceedings of the National Academy of Sciences. 120
TMEM161B encodes an evolutionarily conserved widely expressed novel 8-pass transmembrane protein of unknown function in human. Here we identify TMEM161B homozygous hypomorphic missense variants in our recessive polymicrogyria (PMG) cohort. Patients c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8004bd7e6132dcf8e746b9e59549b72b
https://doi.org/10.1073/pnas.2209983120
https://doi.org/10.1073/pnas.2209983120
Autor:
Jack Houston, Midori Ohta, J. Sebastián Gómez-Cavazos, Amar Deep, Kevin D. Corbett, Karen Oegema, Pablo Lara-Gonzalez, Taekyung Kim, Arshad Desai
During mitosis chromosomes assemble kinetochores in order to dynamically couple with spindle microtubules (Cheeseman, 2014; Musacchio & Desai, 2017). Kinetochores also function as signaling hubs directing mitotic progression by recruiting and control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b55993a6245f7c91966ac3e5e55ead
https://doi.org/10.1101/2022.10.07.511323
https://doi.org/10.1101/2022.10.07.511323
Autor:
Pablo Lara-Gonzalez, Christian O. De Groot, Andrew K. Shiau, Arshad Desai, Jack Houston, Joost Monen, Adina Gerson-Gurwitz, Karen Oegema, Bethany Davis
Publikováno v:
Molecular Biology of the Cell. 32:1193-1201
Caenorhabditis elegans builds centromeres using the histone H3 variant CENP-A but lacks a CENP-A-specific chaperone. This article shows that the extended N-terminal tail of C. elegans CENP-A, which interacts with the conserved loading factor KNL-2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d92fa5f26e311c5361f3c09c5c80572d
https://doi.org/10.1091/mbc.e20-12-0798
https://doi.org/10.1091/mbc.e20-12-0798
Publikováno v:
Science
Science (New York, N.Y.), vol 371, iss 6524
Science (New York, N.Y.), vol 371, iss 6524
Checking fidelity in cell division Everything has to go right during cell division, so a checkpoint mechanism known as the spindle-assembly checkpoint prevents mitosis from proceeding unless the kinetochores that attach chromosomes to the spindle mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb47d24513a557ea90ceaa83654ff75
https://doi.org/10.1126/science.abc1424
https://doi.org/10.1126/science.abc1424
Autor:
Cole J. Ferguson, Olivia Urso, Tatyana Bodrug, Brandon M. Gassaway, Edmond R. Watson, Jesuraj R. Prabu, Pablo Lara-Gonzalez, Raquel C. Martinez-Chacin, Dennis Y. Wu, Karlla W. Brigatti, Erik G. Puffenberger, Cora M. Taylor, Barbara Haas-Givler, Robert N. Jinks, Kevin A. Strauss, Arshad Desai, Harrison W. Gabel, Steven P. Gygi, Brenda A. Schulman, Nicholas G. Brown, Azad Bonni
Publikováno v:
Mol Cell
Neurodevelopmental cognitive disorders provide insights into mechanisms of human brain development. Here, we report an intellectual disability syndrome caused by the loss of APC7, a core component of the E3 ubiquitin ligase anaphase promoting complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ad0480e0b0e927001ea091afcbd10e
https://europepmc.org/articles/PMC8741739/
https://europepmc.org/articles/PMC8741739/