Výsledky vyhledávání - "Pablo José Sáez"

Akademický článek

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

Autor: Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I. Cancino, Nuria Matías, Pablo José Sáez, Alexis Martínez, Alejandra R. Álvarez, Carmen Garcia-Ruiz, José C. Fernandez-Checa, Silvana Zanlungo

Publikováno v: Redox Biology, Vol 12, Iss , Pp 274-284 (2017)

MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in mitochondrial dysfunction. Down-

Externí odkaz: https://doaj.org/article/494d1c1146744392a9897e0212a73156

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Akademický článek

Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity?

Autor: Pablo José Sáez, Roberto eVillalobos-Labra, Francisco eWestermeier, Luis eSobrevia, Marcelo eFarías-Jofré

Publikováno v: Frontiers in Pharmacology, Vol 5 (2014)

Adverse microenvironmental stimuli can trigger the endoplasmic reticulum (ER) stress pathway, which initiates the unfolded protein response (UPR), to restore protein-folding homeostasis. Several studies show induction of ER stress during obesity. Chr

Externí odkaz: https://doaj.org/article/e98ab951575b468581bac1ad03de16dc

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