Current challenges in the treatment of severe Clostridium difficile infection:Early treatment potential of fecal microbiota transplantation

Autor: Abraham Goorhuis, Yvette H. van Beurden, Pablo J. E. J. van de Berg, Chris J. J. Mulder, Max Nieuwdorp

Publikováno v: Van Beurden, Y H, Nieuwdorp, M, Van De Berg, P J E J, Mulder, C J J & Goorhuis, A 2017, ' Current challenges in the treatment of severe Clostridium difficile infection : Early treatment potential of fecal microbiota transplantation ', Therapeutic Advances in Gastroenterology, vol. 10, no. 4, pp. 373-381 . https://doi.org/10.1177/1756283X17690480

Fecal microbiota transplantation (FMT) is a very effective treatment for recurrent Clostridium difficile infection (CDI). Less is known about the application of FMT as a curative treatment of severe or complicated CDI. In this review, we present and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15a3fdb8deb7b1f4aadc21e3682161f
https://research.vumc.nl/en/publications/beaa0cce-35a9-4291-82fc-ea65728ab494

Human Cytomegalovirus Induces Systemic Immune Activation Characterized by a Type 1 Cytokine Signature

Autor: Robert C. Minnee, René A. W. van Lier, Ineke J. M. ten Berge, Si La Young, Kirstin M. Heutinck, Karlijn A. van Donselaar-van der Pant, Robin Raabe, Frederike J. Bemelman, Pablo J. E. J. van de Berg

Publikováno v: Journal of infectious diseases, 202(5), 690-699. Oxford University Press

Mechanisms underlying the onset and perpetuation of chronic immune activation in individuals without overt infectious or autoimmune diseases are unclear. Cytomegalovirus (CMV) is a persistent virus that induces a permanent increase of highly differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0699507fb152613f3e037bfb8335ba
https://doi.org/10.1086/655472

Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia

Autor: Ineke J. M. ten Berge, Marie José Kersten, René A. W. van Lier, Sanne H. Tonino, Marinus H. J. van Oers, Pablo J. E. J. van de Berg, Si La Yong, Arnon P. Kater

Publikováno v: Leukemia & lymphoma, 53(9), 1785-1794. Informa Healthcare

In patients with chronic lymphocytic leukemia (CLL), numbers of CD8 + CD45RA +/- CD27- effector T cells are expanded. We investigated whether this expansion is also present in other B cell malignancies and the possible mechanism underlying these chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf3b6a2ccad842a8aedbd66c407795d
https://pure.amc.nl/en/publications/expansion-of-effector-t-cells-associated-with-decreased-pd1-expression-in-patients-with-indolent-b-cell-lymphomas-and-chronic-lymphocytic-leukemia(9cc86336-bd5f-4819-bfef-c352e6ed2443).html

Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool

Autor: Stephen J. Griffiths, S. L. Yong, Richard Macaulay, René A. W. van Lier, Sarah E. Jackson, Frederike J. Bemelman, Pablo J. E. J. van de Berg, Ineke J. M. ten Berge, Sian M. Henson, Arne N. Akbar

Publikováno v: Journal of immunology (Baltimore, Md., 184(7), 3417-3423. American Association of Immunologists

Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations in telomere length are unknown. We hypothesized that induction of differentiated T cells dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7c2a17372d917eb8e1d9a76d74a89e
https://pure.amc.nl/en/publications/cytomegalovirus-infection-reduces-telomere-length-of-the-circulating-t-cell-pool(14916702-c45f-4c84-a67a-09d0c54f7c88).html

A fingerprint left by cytomegalovirus infection in the human T cell compartment

Autor: Pablo J. E. J. van de Berg, Amber van Stijn, René A. W. van Lier, Ineke J. M. ten Berge

Publikováno v: Journal of clinical virology, 41(3), 213-217. Elsevier

Latent infection with human cytomegalovirus (HCMV) is accompanied by a strong increase in the number of resting, effector-type CD4+ and CD8+ T cells with constitutive cytolytic activity in the circulation. Longitudinal studies in kidney transplant re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f512b413f636264bc01016c276d0711
https://pubmed.ncbi.nlm.nih.gov/18061537