Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Pablo J, Ross"'
Autor:
Insung Park, Sergio Navarro-Serna, Raquel M. Pinho, Trish Berger, Elizabeth A. Maga, Joaqu?n Gadea, Seung K. Kim, Pablo J. Ross
Publikováno v:
Re:GEN Open, Vol 4, Iss 1, Pp 9-20 (2024)
Introduction: CRISPR/Cas9-mediated editing of embryos through microinjection is limited in efficiency because of high rates of mosaicism and off-target mutations. Electroporation has been proposed as an easier and faster procedure compared to single
Externí odkaz:
https://doaj.org/article/ca79aef459f941d493f6c8f1535e9b85
Autor:
Maci L. Mueller, Bret R. McNabb, Joseph R. Owen, Sadie L. Hennig, Alba V. Ledesma, Mitchell L. Angove, Alan J. Conley, Pablo J. Ross, Alison L. Van Eenennaam
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
NANOS3 is expressed in migrating primordial germ cells (PGCs) to protect them from apoptosis, and it is known to be a critical factor for germline development of both sexes in several organisms. However, to date, live NANOS3 knockout (KO) cattle have
Externí odkaz:
https://doaj.org/article/bb5e53530cf64fdbaedd03b77d8af4c0
Autor:
Yuelin Yao, Shuli Liu, Charley Xia, Yahui Gao, Zhangyuan Pan, Oriol Canela-Xandri, Ava Khamseh, Konrad Rawlik, Sheng Wang, Bingjie Li, Yi Zhang, Erola Pairo-Castineira, Kenton D’Mellow, Xiujin Li, Ze Yan, Cong-jun Li, Ying Yu, Shengli Zhang, Li Ma, John B. Cole, Pablo J. Ross, Huaijun Zhou, Chris Haley, George E. Liu, Lingzhao Fang, Albert Tenesa
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Cross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited to model organisms
Externí odkaz:
https://doaj.org/article/8e63f5a62bc44afea9ce80f059475d95
Autor:
Stephen Meek, Tom Watson, Lel Eory, Gus McFarlane, Felicity J. Wynne, Stephen McCleary, Laura E. M. Dunn, Emily M. Charlton, Chloe Craig, Barbara Shih, Tim Regan, Ryan Taylor, Linda Sutherland, Anton Gossner, Cosmin Chintoan-Uta, Sarah Fletcher, Philippa M. Beard, Musa A. Hassan, Finn Grey, Jayne C. Hope, Mark P. Stevens, Monika Nowak-Imialek, Heiner Niemann, Pablo J. Ross, Christine Tait-Burkard, Sarah M. Brown, Lucas Lefevre, Gerard Thomson, Barry W. McColl, Alistair B. Lawrence, Alan L. Archibald, Falko Steinbach, Helen R. Crooke, Xuefei Gao, Pentao Liu, Tom Burdon
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and
Externí odkaz:
https://doaj.org/article/cf7ad4f4a1df46abb42ac71785840eab
Autor:
Dailu Guan, Michelle M. Halstead, Alma D. Islas-Trejo, Daniel E. Goszczynski, Hans H. Cheng, Pablo J. Ross, Huaijun Zhou
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
To identify and annotate transcript isoforms in the chicken genome, we generated Nanopore long-read sequencing data from 68 samples that encompassed 19 diverse tissues collected from experimental adult male and female White Leghorn chickens. More tha
Externí odkaz:
https://doaj.org/article/915560d8bc5a44b6a2e37a48342c5262
Autor:
Maria Questa, Maryam Moshref, Robert J. Jimenez, Veronica Lopez‐Cervantes, Charles K. Crawford, Matthew L. Settles, Pablo J. Ross, Amir Kol
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 441-454 (2021)
Abstract Naturally occurring disease in pet dogs is an untapped and unique resource for stem cell‐based regenerative medicine translational research, given the many similarities and complexity such disease shares with their human counterparts. Cani
Externí odkaz:
https://doaj.org/article/d67bbb971eca48b1beb4fa3850d5d57e
Autor:
Joseph R. Owen, Sadie L. Hennig, Bret R. McNabb, Tamer A. Mansour, Justin M. Smith, Jason C. Lin, Amy E. Young, Josephine F. Trott, James D. Murray, Mary E. Delany, Pablo J. Ross, Alison L. Van Eenennaam
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background The homologous recombination (HR) pathway is largely inactive in early embryos prior to the first cell division, making it difficult to achieve targeted gene knock-ins. The homology-mediated end joining (HMEJ)-based strategy has b
Externí odkaz:
https://doaj.org/article/8631b0fe8f854c6b809a56145bbc2a7d
Autor:
Sadie L. Hennig, Joseph R. Owen, Jason C. Lin, Amy E. Young, Pablo J. Ross, Alison L. Van Eenennaam, James D. Murray
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract The CRISPR/Cas9 genome editing tool has the potential to improve the livestock breeding industry by allowing for the introduction of desirable traits. Although an efficient and targeted tool, the CRISPR/Cas9 system can have some drawbacks, i
Externí odkaz:
https://doaj.org/article/a638503bf58644bba5b9de2748db09bb
Autor:
Michelle M. Halstead, Colin Kern, Perot Saelao, Ying Wang, Ganrea Chanthavixay, Juan F. Medrano, Alison L. Van Eenennaam, Ian Korf, Christopher K. Tuggle, Catherine W. Ernst, Huaijun Zhou, Pablo J. Ross
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Although considerable progress has been made towards annotating the noncoding portion of the human and mouse genomes, regulatory elements in other species, such as livestock, remain poorly characterized. This lack of functional an
Externí odkaz:
https://doaj.org/article/021ea6b0f94e46c5a3998910d08cf005
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Preimplantation embryos undergo extensive transcriptomic and epigenomic remodeling. Here the authors assay open chromatin in bovine oocytes, embryos, and embryonic stem cells, and compare the transcriptomes and epigenomes of cattle, human and mouse e
Externí odkaz:
https://doaj.org/article/adda09c2b03041b794820756fb6f469e