Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Pablo Huertas"'
Autor:
Daniel Salas-Lloret, Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín, Arnoud H. de Ru, Peter A. van Veelen, Pablo Huertas, Alfred C. O. Vertegaal, Román González-Prieto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer with ubiquitin E3
Externí odkaz:
https://doaj.org/article/3e5701fc02264129ac1bfa7414d7e198
Autor:
Sonia Jimeno, Rosario Prados-Carvajal, María Jesús Fernández-Ávila, Sonia Silva, Domenico Alessandro Silvestris, Martín Endara-Coll, Guillermo Rodríguez-Real, Judit Domingo-Prim, Fernando Mejías-Navarro, Amador Romero-Franco, Silvia Jimeno-González, Sonia Barroso, Valeriana Cesarini, Andrés Aguilera, Angela Gallo, Neus Visa, Pablo Huertas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I
Externí odkaz:
https://doaj.org/article/09d9d77f3a254b6e952ffa2219df630e
Publikováno v:
FEBS Open Bio, Vol 11, Iss 3, Pp 622-632 (2021)
The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing flanking chromatin. Here, we
Externí odkaz:
https://doaj.org/article/a7b7abe3664d43cfb15a9c1840ad0911
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for
Externí odkaz:
https://doaj.org/article/54db10d75f0f47d8878b50011974a189
Autor:
Judit Domingo-Prim, Martin Endara-Coll, Franziska Bonath, Sonia Jimeno, Rosario Prados-Carvajal, Marc R. Friedländer, Pablo Huertas, Neus Visa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis o
Externí odkaz:
https://doaj.org/article/8660cb7f19ec4cacaf434de3f58eee41
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several path
Externí odkaz:
https://doaj.org/article/2eb1557ff80c43ffb5f2a1225e749225
Autor:
Fernando R Balestra, Andrés Domínguez-Calvo, Benita Wolf, Coralie Busso, Alizée Buff, Tessa Averink, Marita Lipsanen-Nyman, Pablo Huertas, Rosa M Ríos, Pierre Gönczy
Publikováno v:
eLife, Vol 10 (2021)
TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we
Externí odkaz:
https://doaj.org/article/43c73efe37f44b62a2ac44ad88b4b1c6
Autor:
Fernando Mejías-Navarro, Guillermo Rodríguez-Real, Javier Ramón, Rosa Camarillo, Pablo Huertas
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008787 (2020)
During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection is activated, the break will be channeled through homologous recombination; if not, it will be simply ligated using the non-h
Externí odkaz:
https://doaj.org/article/fd2e6cc2be4e4c9eb9103b14ceebef18
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead
Externí odkaz:
https://doaj.org/article/f80b5fb8431a48af955ae03d4fdc956d
Autor:
Gonzalo Hernández, María José Ramírez, Jordi Minguillón, Paco Quiles, Gorka Ruiz de Garibay, Miriam Aza-Carmona, Massimo Bogliolo, Roser Pujol, Rosario Prados-Carvajal, Juana Fernández, Nadia García, Adrià López, Sara Gutiérrez-Enríquez, Orland Diez, Javier Benítez, Mónica Salinas, Alex Teulé, Joan Brunet, Paolo Radice, Paolo Peterlongo, Detlev Schindler, Pablo Huertas, Xose S Puente, Conxi Lázaro, Miquel Àngel Pujana, Jordi Surrallés
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Mutations in BRCA1 are associated with an increased risk of breast and ovarian cancer. Here the authors show that EDC4, a component of P-bodies, is a member of the BRCA1 complex with roles in stimulating end resection at breaks.
Externí odkaz:
https://doaj.org/article/9dd58df3757244329f9ae097492e7706