Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Pablo Hernán Palestro"'
1
Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity
Autor: Pablo Hernán Palestro, Andrea Enrique, Pedro Martín, Valentina Pastore, Luciana Gavernet, María Laura Sbaraglini, Laureano Leonel Sabatier
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1465-1473 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
In this investigation, we studied a family of compounds with an oxathiazolidine-4-one-2,2-dioxide skeleton and their amide synthetic precursors as new anticonvulsant drugs. The cyclic structures were synthesized using a three-step protocol that inclu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1841d138c113b041c0afb791f4d41fb
https://pubmed.ncbi.nlm.nih.gov/31411081
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2
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents
Autor: Pedro Martín, Maria Villalba, Luciana Gavernet, Sofía Goicoechea, Nicolás Jorge Enrique, Luis Enrique Bruno Blanch, Pablo Hernán Palestro, Verónica Milesi, Laureano Leonel Sabatier
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9e458886f9780fe8dccb7661ff689d
http://pubs.acs.org/doi/10.1021/acs.jcim.7b00721
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3
Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake
Autor: Juan Francisco Morales, Agustina María Pino Martínez, María Daniela Ruiz, Lucas Nicolás Alberca, Pablo Hernán Palestro, María Laura Sbaraglini, Catalina D. Alba Soto, Roque Carlos Dietrich, Alan Talevi, Laura Virginia Fraccaroli, Carolina Carrillo, Cristian Gabriel Miranda
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cellular and Infection Microbiology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and structure-based methods. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ca34a9bef8119aedd5953fcd274f49
https://doi.org/10.3389/fcimb.2018.00173
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4
Identification of cisapride as new inhibitor of putrescine uptake in Trypanosoma cruzi by combined ligand- and structure-based virtual screening
Autor: Pablo Hernán Palestro, María Daniela Ruiz, Roque Carlos Dietrich, Luciana Gavernet, Alan Talevi, Carolina Carrillo, Lucas Nicolás Alberca
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nowadays, the pharmacological therapy for the treatment of Chagas disease is based on two old drugs, benznidazole and nifurtimox, which have restricted efficacy against the chronic phase of the illness. To overcome the lack of efficacy of the traditi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae1afe47adbef1d7de490a634271d97
http://sedici.unlp.edu.ar/handle/10915/101758
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5
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy
Autor: Andrea Enrique, Pablo Hernán Palestro, Guido Pesce, Alan Talevi, Manuel Couyoupetrou, María Esperanza Ruiz, Luis E. Bruno-Blanch, Luciana Gavernet, Melisa Edith Gantner, Mauricio E. Di Ianni
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Despite the introduction of more than 15 third generation antiepileptic drugs to the market from 1990 to the moment, about one third of the epileptic patients still suffer from refractory to intractable epilepsy. Several hypotheses seek to explain th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b125d60b062e7122d2126747ec893a8
http://sedici.unlp.edu.ar/handle/10915/103425
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6
Búsqueda de nuevos anticonvulsivos a partir de métodos computacionales
Autor: Pablo Hernán Palestro
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
La epilepsia es uno de los desórdenes neurológicos crónicos de mayor prevalencia en el mundo. De acuerdo a la Organización Mundial de la Salud, afecta a alrededor de 50 millones de personas, presentando una mayor incidencia en países en vías de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e65d0c6b0062ac9018b929032bbb96d
https://doi.org/10.35537/10915/53752
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8
Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
Autor: Cecilia Saiz, Graciela Mahler, Agustina Chidichimo, Luis Enrique Bruno Blanch, Alan Talevi, Diego Benítez, Peter Wipf, Pablo Hernán Palestro, Carolina Leticia Bellera, Luciana Gavernet, Chiara Pizzo, Juan José Cazzulo
Publikováno v: Chemical Biology & Drug Design. 77:166-172
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a745321303bf27d35d13e7e4a386b3fa
https://doi.org/10.1111/j.1747-0285.2010.01071.x
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9
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action
Autor: Jose L. Gonzalez Funes, Pablo Hernán Palestro, Mariangela Ceruso, Luis Enrique Bruno Blanch, Claudiu T. Supuran, Maria Villalba, Luciana Gavernet, Alan Talevi
Publikováno v: Bioorganicmedicinal chemistry. 24(4)
A set of N,N0 -disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0db4990612b4cc2ceec11416d008181
https://pubmed.ncbi.nlm.nih.gov/26795114
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