Folate Carrier Deficiency Drives Differential Methylation and Enhanced Cellular Potency in the Neural Plate Border

Autor: Nagif Alata Jimenez, Pablo H. Strobl-Mazzulla

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

The neural plate border (NPB) of vertebrate embryos segregates from the neural and epidermal regions, and it is comprised of an intermingled group of multipotent progenitor cells. Folate is the precursor of S-adenosylmethionine, the main methyl donor

Externí odkaz: https://doaj.org/article/53489106b4ed4fc187c4d02bbc71fa25

Extracellular vesicle-localized miR-203 mediates neural crest-placode communication required for trigeminal ganglia formation

Autor: Yanel E Bernardi, Estefania Sanchez-Vasquez, Michael L. Piacentino, Hugo Urrutia, Izadora Rossi, Karina Lidianne Alcântara Saraiva, Antonio Pereira-Neves, Marcel Ivan Ramirez, Marianne E. Bronner, Natalia de Miguel, Pablo H. Strobl-Mazzulla

Publikováno v: bioRxiv

While interactions between neural crest and placode cells are critical for the proper formation of the trigeminal ganglion, the mechanisms underlying this process remain largely uncharacterized. Here, we show that the microRNA-(miR)203, whose epigene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ed39e71b4da80123f0a9a92b4f06a7
https://doi.org/10.1101/2023.03.14.532527

What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Autor: Yanel Bernardi, Pablo H. Strobl-Mazzulla

Publikováno v: The Biochemical journal. 478(9)

Epithelial plasticity involved the terminal and transitional stages that occur during epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), both are essential at different stages of early embryonic development tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f856f4edaf1de99c75918b0bcc31149
https://pubmed.ncbi.nlm.nih.gov/33988704

Adenine DNA methylation, 3D genome organization, and gene expression in the parasite Trichomonas vaginalis

Autor: Natalia de Miguel, Konstantinos Boulias, Patricia J. Johnson, Zach Klapholz O’Brown, Pablo H. Strobl-Mazzulla, Ayelen Lizarraga, Lara Roach, Eric L. Greer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 23
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract causing infections that range from asymptomatic to highly inflammatory. Recent works have highlighted the importance of histone modifications in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0978c9d54d041a99a5ecfef31686ca2
https://escholarship.org/uc/item/7v66f295

Epigenetic activation of Sox2 gene in the developing vertebrate neural plate

Autor: Melisa S. Marini, David A. Morales Vicente, Santiago O. Bouzas, Eliana Torres Zelada, Pablo H. Strobl-Mazzulla, Ailín L. Buzzi

Publikováno v: Molecular Biology of the Cell
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The in vivo requirement of the histone demethylase JmjD2A, together with the kinase MSK1, results in a series of epigenetic events necessary for early activation of Sox2 and subsequent neural fate commitment in vertebrates.
One of the earliest m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164edd4dc61b5e5dad35223dcf7821b2
http://europepmc.org/articles/PMC4907725