The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study

Autor: Anna Wawruszak, Wiesława Bednarek, Magdalena Dmoszyńska-Graniczka, Iwona Wertel, Pablo Garcia-Sanz, Jan Kotarski, Karolina Okła, Marcin Bobiński

Publikováno v: Archivum Immunologiae et Therapiae Experimentalis

The aim of the study was to assess the activity of fucoidan on the uterine sarcomas (MES-SA and ESS-1) and carcinosarcoma cell lines (SK-UT-1 and SK-UT-1B) and its toxicity on the human skin fibroblasts (HSF). Two uterine sarcomas and two carcinosarc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85380a1dd9ca4b7797288570b579d56
http://europepmc.org/articles/PMC6420609

Gemcitabine and Selected mTOR Inhibitors in Uterine Sarcomas and Carcinosarcoma Cells- an Isobolographic Analysis

Autor: Karolina Okła, Magdalena Dmoszyńska-Graniczka, Wiesława Bednarek, Marcin Bobiński, Pablo Garcia-Sanz, Rafał Tarkowski, Jarogniew J. Łuszczki, Jan Kotarski, Anna Wawruszak, Gema Moreno-Bueno

Publikováno v: International Journal of Medical Sciences

Introduction: mTOR inhibitors are anticancer agents affecting mTOR/AKT/PI3K pathway that is one of the most important in human cancer cells. Hyperactivation of mTOR/AKT/PI3K and overexpression of this pathway members are frequently reported in uterin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48257b82c6c1dc25dbaef4508c87ea0
https://pubmed.ncbi.nlm.nih.gov/33173419

Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers

Autor: Alejandro Rojo-Sebastian, Sonia Gatius, Xavier Matias-Guiu, Luis Chiva, Jaume Reventós, Eva Colás, Antonio Gil-Moreno, Irene Campoy, Marcin Bobiński, Ángel García, August Vidal, Rafael López-López, Patrycja Ziober-Malinowska, Miguel Abal, Alba Mota, Berta Díaz-Feijoo, Pablo Garcia-Sanz, Xavier Gonzalez-Tallada, Sonsoles Alonso, Gema Moreno-Bueno

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Endometrial cancer is the most common cancer of the female genital tract in developed countries. Although the majority of endometrial cancers are diagnosed at early stages and the 5-year overall survival is around 80%, early detection of these tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e508ff2cda956ea56858f0ad7a4061d
http://hdl.handle.net/10261/150778

A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer

Autor: Marta Hergueta-Redondo, Gema Moreno-Bueno, M. Angeles López-García, Xavier Matias-Guiu, Juan Díaz-Martín, M Ángeles Castilla, Laura Romero-Pérez, Susanna Leskelä, Pablo Garcia-Sanz, José Palacios, Ángel Martínez-Ramírez, Alba Mota, Robert A. Soslow

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Although TAZ, the final effector of the Hippo pathway that modulates epithelial to mesenchymal transition and stemness, has been implicated in the development of different types of cancer, its role in endometrial cancer has not yet been studied. Thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86254519ca4b0ef0cb52d604e0c538d5
http://hdl.handle.net/10261/154311

Sin3b Interacts with Myc and decreases Myc levels

Autor: M. Carmen Lafita, Ignacio Varela, Pablo Garcia-Sanz, Javier León, Vedrana Tabor, Yuzuru Shiio, Lars-Gunnar Larsson, Lucía García-Gutiérrez, Gema Moreno-Bueno, Francisco Portillo, Andrea Quintanilla

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
J Biol Chem. 2014 Aug 8;289(32):22221-36
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

et al.
Myc expression is deregulated in many human cancers. A yeast two-hybrid screen has revealed that the transcriptional repressor Sin3b interacts with Myc protein. Endogenous Myc and Sin3b co-localize and interact in the nuclei of human and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8675fafc14ab61ba7a93f05ab8b04a27
http://hdl.handle.net/10261/124572