Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pablo Gabatto"'
Publikováno v:
Neuroscience. 310:306-321
The state of protein folding in the endoplasmic reticulum (ER), via the unfolded protein response (UPR), regulates a pro- or anti-apoptotic cell fate. Hypoxic preconditioning (HPC) is a potent anti-apoptotic stimulus, wherein ischemic neural injury i
Publikováno v:
Journal of neurosurgical anesthesiology. 29(4)
Background Repeated episodes of reduced glucose availability can precondition the brain against damage caused by severe hypoglycemia. Because N-methyl-D-aspartate (NMDA) receptor activation may contribute to neuronal loss in the hippocampus following
Autor:
Heather Brosnan, Pablo Gabatto, John P. Clark, Daniel E. Warren, Maren Gregersen, Philip E. Bickler
Publikováno v:
Anesthesiology. 117:280-292
Background Mild hypothermia is neuroprotective after cerebral ischemia but surgery involving profound hypothermia (PH, temperature less than 18°C) is associated with neurologic complications. Rewarming (RW) from PH injures hippocampal neurons by glu
Autor:
Philip E. Bickler, Heather Brosnan, Pablo Gabatto, John P. Clark, Maren Gregersen, William McKleroy, Daniel E. Warren
Publikováno v:
Neuroscience. 207:316-325
This study examines the causes of hypothermia and rewarming injury in CA1, CA3, and dentate neurons in rat hippocampal slice cultures. Neuronal death, assessed with propidium iodide or Sytox® fluorescence, Fluoro-Jade labeling, and Cresyl Violet sta
Autor:
Fuying Gao, Sergio E. Baranzini, Derek J. Pappas, Daniel H. Geschwind, Pablo Gabatto, Jorge R. Oksenberg, Giovanni Coppola
Publikováno v:
Physiological Genomics. 38:362-371
Type I interferons (IFNs) are pleiotropic cytokines that modulate both innate and adaptive immune responses. They have been used to treat autoimmune disorders, cancers, and viral infection and have been demonstrated to elicit differential responses w
Autor:
D. A. S. Compston, J. L. Haines, Lisa F. Barcellos, Stephen L. Hauser, Margaret A. Pericak-Vance, Patricia P. Ramsay, Stacy J. Caillier, Jorge R. Oksenberg, Silke Schmidt, Stephen Sawcer, Pablo Gabatto
Publikováno v:
Genes & Immunity. 9:493-500
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component. Variation in the major histocompatibility complex on chromosome 6p21, specifically the HLA-DRB1*15 haplotype, is the strongest g
Publikováno v:
Therapeutic hypothermia and temperature management. 3(4)
Mild hypothermia (33°C-34°C) after cerebral ischemia in intact animals or ischemia-like conditions in vitro reduces neuron death. However, it is now clear that more profound hypothermia or delayed hypothermia may not provide significant protection.
Autor:
Jorge R. Oksenberg, Li Gan, Sergio E. Baranzini, Derek J. Pappas, Pablo Gabatto, Pouya Khankhanian, D. Oksenberg
Publikováno v:
Pappas, DJ; Gabatto, PA; Oksenberg, D; Khankhanian, P; Baranzini, SE; Gan, L; et al.(2012). Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience, 226, 10-20. doi: 10.1016/j.neuroscience.2012.09.007. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8k2646qr
Glutamate-mediated excitotoxicity has been purported to underlie many neurodegenerative disorders. A subtype of glutamate receptors, namely N-methyl-d-aspartate (NMDA) receptors, has been recognized as potential targets for neuroprotection. To increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8593994f4dcc8e29a73bada5b9b8e032
https://escholarship.org/uc/item/8k2646qr
https://escholarship.org/uc/item/8k2646qr
Autor:
Philip E, Bickler, Daniel E, Warren, John P, Clark, Pablo, Gabatto, Maren, Gregersen, Heather, Brosnan
Publikováno v:
Anesthesiology. 117(2)
Mild hypothermia is neuroprotective after cerebral ischemia but surgery involving profound hypothermia (PH, temperature less than 18°C) is associated with neurologic complications. Rewarming (RW) from PH injures hippocampal neurons by glutamate exci
Publikováno v:
The FASEB Journal. 25