Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pablo F. Canete"'
Autor:
Melisa Gorosito Serrán, Facundo Fiocca Vernengo, Laura Almada, Cristian G. Beccaria, Yamila Gazzoni, Pablo F. Canete, Jonathan A. Roco, Jimena Tosello Boari, Maria Cecilia Ramello, Ellen Wehrens, Yeping Cai, Elina I. Zuniga, Carolina L. Montes, Ian A. Cockburn, Eva V. Acosta Rodriguez, Carola G. Vinuesa, Adriana Gruppi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation product of
Externí odkaz:
https://doaj.org/article/e2cf7f337a5340039ee73c984b6bf218
Autor:
Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in th
Externí odkaz:
https://doaj.org/article/78a180011b6f49c096a0159adcd221f4
Autor:
Melisa Gorosito Serrán, Facundo Fiocca Vernengo, Laura Almada, Cristian G. Beccaria, Yamila Gazzoni, Pablo F. Canete, Jonathan A. Roco, Jimena Tosello Boari, Maria Cecilia Ramello, Ellen Wehrens, Yeping Cai, Elina I. Zuniga, Carolina L. Montes, Ian A. Cockburn, Eva V. Acosta Rodriguez, Carola G. Vinuesa, Adriana Gruppi
Publikováno v:
Frontiers in immunology. 13
During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation product of
Autor:
Carola G. Vinuesa, Pablo F. Canete
Publikováno v:
Cell
Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SA
Autor:
Grant Brown, Huihua Ding, Eric Mallack, Xiangpeng Meng, Gaetan Burgio, Yaoyuan Zhang, Pablo F. Canete, Denis Tvorogov, T. Andrews, Lisa A. Miosge, Angel F. Lopez, Cynthia Turnbull, Carola G. Vinuesa, Julia I. Ellyard, Jean Capello, Arti Medhavy, Jeffrey J. Babon, Philip Wu, Carmen de Lucas Collantes, Matthew A. Field, Cristina Aparicio López, Yuke He, Katharine J. Bassett, Vicky Athanasopoulos, Africa Gonzalez-Murillo, Virginia Pascual, Matthew C. Cook, Vicky Cho, Tess Levy, Nan Shen
While circumstantial evidence supports enhanced TLR7 signaling as a mechanism of human systemic autoimmune disease, we have lacked the proof afforded by lupus-causing TLR7 gene variants. Here we describe monogenic human systemic lupus erythematosus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62dff7a3d6e1eae520d09cf1b0a119cf
https://doi.org/10.21203/rs.3.rs-152145/v1
https://doi.org/10.21203/rs.3.rs-152145/v1
Autor:
Adriana Gruppi, Ian A. Cockburn, María Cecilia Ramello, Rodriguez Eva, Jimena Tosello Boari, Pablo F. Canete, Carolina L. Montes, Melisa Gorosito Serran, Facundo Fiocca Vernengo, Yeping Cai, Cristian Gabriel Beccaria, Laura Almada, Carola G. Vinuesa, Alegre, Zuniga I E, Wehrens E
During infections with protozoan parasites or virus, T cell immunosuppression is generated simultaneously with a high B cell activation. Here, we show that in T. cruzi infection, all plasmablasts detected had higher surface expression of PD-L1, than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52b5ddb3f4ba16e88b6b463ad7e7868
https://doi.org/10.1101/2020.06.10.142067
https://doi.org/10.1101/2020.06.10.142067
Autor:
Simon H. Jiang, Sevcan Mercan, Ilenia Papa, Max Moldovan, Giles D. Walters, Mark Koina, Mitali Fadia, Maurice Stanley, Tom Lea-Henry, Amelia Cook, Julia Ellyard, Brendan McMorran, Madhivanan Sundaram, Russell Thomson, Pablo F. Canete, Wendy Hoy, Holly Hutton, Monika Srivastava, Kathryn McKeon, Iñigo de la Rúa Figueroa, Ricard Cervera, Raquel Faria, Sandra D’Alfonso, Mariele Gatto, Vicki Athanasopoulos, Matthew Field, John Mathews, Eun Cho, Thomas D. Andrews, A. Richard Kitching, Matthew C. Cook, Marta Alarcon Riquelme, Melanie Bahlo, Carola G. Vinuesa
Publikováno v:
Cell Reports Medicine
Summary We identify an intronic deletion in VANGL1 that predisposes to renal injury in high risk populations through a kidney-intrinsic process. Half of all SLE patients develop nephritis, yet the predisposing mechanisms to kidney damage remain poorl
Autor:
Salvatore Valvo, Pablo F. Canete, Ilenia Papa, Michael Meyer-Hermann, David Saliba, Claudio Doglioni, Carola G. Vinuesa, Maurilio Ponzoni, Hayley A. McNamara, Michele A. Grimbaldeston, Paula Gonzalez-Figueroa, Rebecca A. Sweet, Ian A. Cockburn, Harpreet Vohra, Sonia Bustamante, Michael L. Dustin
Publikováno v:
Nature
Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (T FH ) cells in germinal centres. The rapid T-B-cell interactions that occur during this proc
Autor:
Marija Jelušić, Philip Wu, Jean Cappello, Anselm Enders, Maurice Stanley, Ilenia Papa, Julia I. Ellyard, Jeffrey J. Babon, Gaetan Burgio, Eric A. Stone, Jinghua Gu, Aaron Chuah, Lisa A. Miosge, Pablo F. Canete, Carmen de Lucas Collantes, James M. Byers, Jacob Cardenas, T. Andrews, Paul A. Gatenby, Matthew C. Cook, Kathryn P McKeon, Todor Arsov, Nan Shen, Eun Cho, Stephen I. Alexander, Arthur R Kitching, Matthew A. Field, David A. Fulcher, Virginia Pascual, Vicki Athanasopoulos, Savit B. Prabhu, Carola G. Vinuesa, Adrian C. Lungu, Giles Walters, Jonathan A. Roco, Velibor Tasic, Charlotte Burrin, Simon H Jiang, Amelia G. Cook, Mehmet Yabas, Dominic Mallon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci of weak effect act additively to predispose to common autoimmune diseases, while the contribution of rare variants rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd57f7c75cb27d937f805b8ceadb96b7
http://doi.org/10.1038/s41467-019-10242-9
http://doi.org/10.1038/s41467-019-10242-9
Autor:
Matthew C. Cook, Ismail Sayin, Holly A. Bolton, Michael Meyer-Hermann, Emma F Barry, Claudio Doglioni, Barbara Fazekas de St Groth, Katharine J. Bassett, Paula Gonzalez-Figueroa, Naganari Ohkura, Rebecca A. Sweet, Marta Cuenca, David H. Canaday, Pablo F. Canete, Jonathan A. Roco, Angel F. Lopez, Shimon Sakaguchi, Carola G. Vinuesa, Ilenia Papa
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine
Journal of Experimental Medicine 216 (2019) 8, p. 1843-1856--The journal of experimental medicine--J. Exp. Med.--The journal of experimental medicine--0022-1007--1540-9538
The Journal of experimental medicine
Journal of Experimental Medicine 216 (2019) 8, p. 1843-1856--The journal of experimental medicine--J. Exp. Med.--The journal of experimental medicine--0022-1007--1540-9538
Uncontrolled IgE responses drive allergies and anaphylaxis. Here, Cañete et al. describe a human follicular regulatory T cell population that does not express FOXP3 and produces abundant IL-10, which limits IgE switching. These cells appear to be ke