Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pablo E. Morales"'
Autor:
César Vásquez-Trincado, Mario Navarro-Márquez, Pablo E. Morales, Francisco Westermeier, Mario Chiong, Valentina Parra, Alejandra Espinosa, Sergio Lavandero
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Cardiovascular diseases, especially metabolic-related disorders, are progressively growing worldwide due to high-fat-containing foods, which promote a deleterious response at the cellular level, termed lipotoxicity, or lipotoxic stress.
Externí odkaz:
https://doaj.org/article/ec941d61e8a64c7a84b3f79f7dee5b6e
Autor:
Marina García-Miguel, Jaime A Riquelme, Ignacio Norambuena-Soto, Pablo E Morales, Fernanda Sanhueza-Olivares, Constanza Nuñez-Soto, David Mondaca-Ruff, Nicole Cancino-Arenas, Alejandra San Martín, Mario Chiong
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197210 (2018)
Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC
Externí odkaz:
https://doaj.org/article/b0d6e8556f054aa1bafd24fa673ae7c3
Autor:
Vitor A. Lira, Gourav Bhardwaj, E. Dale Abel, William I. Sivitz, Kennedy Poro, Antentor Othrell Hinton, Brian T. O’Neill, Taylor L. Junck, Jayashree Jena, Pablo E. Morales, Jordan D. Fuqua, Rhonda Souvenir, Pablo A. Suarez Beltran, Collin M. Foster, Roberto Bravo-Sagua, Christie M. Penniman
Publikováno v:
J Clin Invest
Decreased skeletal muscle strength and mitochondrial dysfunction are characteristic of diabetes. The actions of insulin and IGF-1 through the insulin receptor (IR) and IGF-1 receptor (IGF1R) maintain muscle mass via suppression of forkhead box O (Fox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8998d4c67081f0a14b7f720715e34025
https://europepmc.org/articles/PMC8439595/
https://europepmc.org/articles/PMC8439595/
Autor:
Pablo E. Morales, Satya Murthy Tadinada, Alejandra Espinosa, Nicole De Gregorio, Matias Monsalves-Alvarez, Andrea Ramírez-Sagredo, Renata O. Pereira, Matthew Harris, Ximena Calle, Sergio Lavandero, Vitor A. Lira, Jafet Ortiz-Quintero, Mayarling Francisca Troncoso, E. Dale Abel
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(10)
In obesity, skeletal muscle mitochondrial activity changes to cope with increased nutrient availability. Autophagy has been proposed as an essential mechanism involved in the regulation of mitochondrial metabolism. Still, the contribution of autophag
Autor:
Pablo E. Morales, Gareth I. Owen, Chukwuemeka R. Nwokocha, Fredi Cifuentes, Mario Chiong, Adrián Paredes, Julio Benites, Javier Palacios
Publikováno v:
Journal of cardiovascular pharmacology. 77(2)
Vasomotion is defined as rhythmic oscillations in arterial diameter that regulate the blood flow and blood pressure. Because antitumor treatment may impair vascular functions and increase the blood pressure, we sought to evaluate whether a new naphth
Autor:
Taylor L. Junck, Gourav Bhardwaj, Brian T. O’Neill, Kennedy Poro, Rhonda Souvenir, Pablo E. Morales, Jordan D. Fuqua, Collin M. Foster, Roberto Bravo-Sagua, Christie M. Penniman, Pablo A. Suarez Beltran, Antentor Othrell Hinton, Jayashree Jena, Vitor A. Lira, Evan Dale Abel
Publikováno v:
Diabetes. 69
Diabetes is associated with decreased muscle strength and mitochondrial metabolism which can lead to disability. Recently, we reported that insulin receptor (IR) and IGF-1 receptor (IGF1R) prevent muscle atrophy via suppression of FoxOs, but how FoxO
Autor:
Juan Manuel Rodríguez, Mauricio Castro-Sepulveda, Rodrigo Troncoso, Matias Monsalves-Alvarez, Verónica Eisner, Mario Chiong, Sergio Lavandero, Carlos Sepúlveda, Pablo E. Morales
Publikováno v:
Nutrients
Nutrients, Vol 12, Iss 1930, p 1930 (2020)
Volume 12
Issue 7
Nutrients, Vol 12, Iss 1930, p 1930 (2020)
Volume 12
Issue 7
&beta
hydroxybutyrate is the main ketone body generated by the liver under starvation. Under these conditions, it can sustain ATP levels by its oxidation in mitochondria. As mitochondria can modify its shape and function under different nutritio
hydroxybutyrate is the main ketone body generated by the liver under starvation. Under these conditions, it can sustain ATP levels by its oxidation in mitochondria. As mitochondria can modify its shape and function under different nutritio
Autor:
Mariana Cifuentes, Pablo E. Morales, Sergio Lavandero, Matias Monsalves-Alvarez, James R. Krycer, Beverly A. Rothermel, Alexis Diaz-Vegas, Pablo Sanchez-Aguilera
Publikováno v:
Endocr Rev
Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in
Autor:
Juan Carlos Roa, Beverly A. Rothermel, Valentina Parra, Alejandro H. Corvalan, Camila López-Crisosto, Pablo E. Morales, Iva Polakovicova, Pablo Rivera-Mejías, César Vásquez-Trincado, María Paz Ocaranza, Hung Ho-Xuan, Vinicius Maracaja-Coutinho, Victor Aliaga-Tobar, Sergio Lavandero, Cristian Sotomayor-Flores, Lorena García, Mario Chiong, Gunter Meister, Christian Pennanen
Publikováno v:
Cell Death Differ
Angiotensin-(1-9) is a peptide from the noncanonical renin-angiotensin system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study we aimed to elucidate it, basing us initially on previous work from our grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa29cedee69a85034cb2e92634bf4b5
https://europepmc.org/articles/PMC7429871/
https://europepmc.org/articles/PMC7429871/
Autor:
Natalia Torrealba, Amira Klip, Pablo E. Morales, Lorena García, Rodrigo Troncoso, Mario Chiong, Marcelo Rodriguez, Enrique Jaimovich, Sergio Lavandero, Koichi Kokame, Mario Navarro-Marquez, Yuka Eura, César Vásquez-Trincado, Elisa Villalobos
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:1653-1662
Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane protein that maintains int