Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pablo D, Garcia"'
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7a0911566c282b44322df88773977
https://doi.org/10.1158/1078-0432.c.6522398
https://doi.org/10.1158/1078-0432.c.6522398
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Figure 3. KINO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf370c3ede2546f0f7aab800bf1d63
https://doi.org/10.1158/1078-0432.22452158.v1
https://doi.org/10.1158/1078-0432.22452158.v1
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 6, Iss 1, Pp 369-379 (2015)
We present a simulation environment, dForce, which can be used for a better understanding of dynamic force microscopy experiments. The simulator presents the cantilever–tip dynamics for two dynamic AFM methods, tapping mode AFM and bimodal AFM. It
Externí odkaz:
https://doaj.org/article/a5220040b6db44aa96bbf15781740b50
Autor:
Catherine E. Gleason, Pablo D. Garcia, Ranya Odeh, Frances Hamkins-Indik, Daphne He, Meisam Nosrati, Gavin Situ, Roberta Sala, Bernard Levin, Li-Fen Liu, Evelyn W. Wang, Siegfried Leung, Breena Fraga, Andrew T. Bockus, Justin Shapiro, Nathan Dupper, Chinmay Bhatt, Kai Yang, Megan DeMart, Sammy Metobo, James Aggen, Peadar Cremin, Ramesh Bambal, Constantine Kreatsoulas, David J. Earp, Rajinder Singh
Publikováno v:
Cancer Research. 83:1560-1560
RB and E2F genes are frequently altered in cancer. Cyclin/Cdk (cyclin-dependent kinase) complexes regulate the activity of RB and E2F to drive cell cycle progression and ensure fidelity of DNA replication. A critical subset of their substrates (Rb, E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0da7b3d05cfd0214fb1750100fd482
https://doi.org/10.1158/1538-7445.am2023-1560
https://doi.org/10.1158/1538-7445.am2023-1560
Autor:
Shilpa Singh, Yavuz T. Durmaz, Catherine E. Gleason, Evelyn W. Wang, Rajinder Singh, David J. Earp, Pablo D. Garcia, Matthew G. Oser
Publikováno v:
Cancer Research. 83:1559-1559
Most cancer-directed targeted therapies are developed using small molecule inhibitors that require a druggable binding pocket on the target of interest. Macrocyclic peptides can selectively block protein-protein interactions required for function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa433aae0bb6b90871de08d2b3c60d6
https://doi.org/10.1158/1538-7445.am2023-1559
https://doi.org/10.1158/1538-7445.am2023-1559
Autor:
Pablo D. Garcia, Catherine E. Gleason, Miles Membreno, Frances Hamkins-Indik, Gavin Situ, Bernard Levin, Evelyn W. Wang, Siegfried Leung, Breena Fraga, Andrew Bockus, James Aggen, David Spellmeyer, David J. Earp, Rajinder Singh
Publikováno v:
Cancer Research. 82:5379-5379
Inhibition of substrate binding to Cyclin A has been postulated to be synthetically lethal in retinoblastoma (Rb) mutated cancers (Chen et al 1999). While compounds that target the cyclin-associated kinases are approved for clinical use, attempts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94cc85dfbb00c536ea96cf5d178016ec
https://doi.org/10.1158/1538-7445.am2022-5379
https://doi.org/10.1158/1538-7445.am2022-5379
Autor:
Matthew T, Burger, Gisele, Nishiguchi, Wooseok, Han, Jiong, Lan, Robert, Simmons, Gordana, Atallah, Yu, Ding, Victoriano, Tamez, Yanchen, Zhang, Michelle, Mathur, Kristine, Muller, Cornelia, Bellamacina, Mika K, Lindvall, Richard, Zang, Kay, Huh, Paul, Feucht, Tatiana, Zavorotinskaya, Yumin, Dai, Steve, Basham, Julie, Chan, Elaine, Ginn, Alex, Aycinena, Jocelyn, Holash, Joseph, Castillo, John L, Langowski, Yingyun, Wang, Min Y, Chen, Amy, Lambert, Christine, Fritsch, Audry, Kauffmann, Estelle, Pfister, K Gary, Vanasse, Pablo D, Garcia
Publikováno v:
Journal of medicinal chemistry. 58(21)
Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM kinase inhibition may provide benefit to cancer patients. Herein, the synthesis, in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::520e2275f65794da2b12343a31ae7d5e
https://pubmed.ncbi.nlm.nih.gov/26505898
https://pubmed.ncbi.nlm.nih.gov/26505898
Autor:
Vijay, Easwaran, Sang H, Lee, Landon, Inge, Lida, Guo, Cheryl, Goldbeck, Evelyn, Garrett, Marion, Wiesmann, Pablo D, Garcia, John H, Fuller, Vivien, Chan, Filippo, Randazzo, Robert, Gundel, Robert S, Warren, Jaime, Escobedo, Sharon L, Aukerman, Robert N, Taylor, Wendy J, Fantl
Publikováno v:
Cancer research. 63(12)
To evaluate whether beta-catenin signaling has a role in the regulation of angiogenesis in colon cancer, a series of angiogenesis-related gene promoters was analyzed for beta-catenin/TCF binding sites. Strikingly, the gene promoter of human vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ed23bdee706edcfac51cf717e1a3d45
https://pubmed.ncbi.nlm.nih.gov/12810642
https://pubmed.ncbi.nlm.nih.gov/12810642
Autor:
Pablo D Garcia, John L Langowski, Jocelyn Holash, Matthew Burger, Richard Zang, Tatiana Zavorotinskaya, Christie Fanton, Abdel Saci, Joseph Growney, K. Gary Vanasse
Publikováno v:
Blood. 122:1666-1666
Background PIM1, PIM2, and PIM3 are a closely related family of constitutively active serine/threonine kinases. PIM kinases were first identified as common integration sites in MMLV-induced murine T-cell lymphomas, with these viral insertions resulti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b6939872b88507a93cde738bd629e3
https://doi.org/10.1182/blood.v122.21.1666.1666
https://doi.org/10.1182/blood.v122.21.1666.1666