Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pablo C Alarcon"'
Autor:
Jarren R. Oates, Keisuke Sawada, Daniel A. Giles, Pablo C. Alarcon, Michelle S.M.A. Damen, Sara Szabo, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Senad Divanovic
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionInflammation is a common unifying factor in experimental models of non-alcoholic fatty liver disease (NAFLD) progression. Recent evidence suggests that housing temperature-driven alterations in hepatic inflammation correlate with exacerba
Externí odkaz:
https://doaj.org/article/1f1bb9be755e44ee861e3cade70d99e3
Autor:
Calvin C. Chan, Isaac T. W. Harley, Paul T. Pfluger, Aurelien Trompette, Traci E. Stankiewicz, Jessica L. Allen, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, Jarren R. Oates, Pablo C. Alarcon, Jessica R. Doll, Matthew J. Flick, Leah M. Flick, Joan Sanchez-Gurmaches, Rajib Mukherjee, Rebekah Karns, Michael Helmrath, Thomas H. Inge, Stuart P. Weisberg, Sünje J. Pamp, David A. Relman, Randy J. Seeley, Matthias H. Tschöp, Christopher L. Karp, Senad Divanovic
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar i
Externí odkaz:
https://doaj.org/article/1874a0fdf3df440c914731f67be8205d
Autor:
Calvin C. Chan, Michelle S. M. A. Damen, Maria E. Moreno-Fernandez, Traci E. Stankiewicz, Monica Cappelletti, Pablo C. Alarcon, Jarren R. Oates, Jessica R. Doll, Rajib Mukherjee, Xiaoting Chen, Rebekah Karns, Matthew T. Weirauch, Michael A. Helmrath, Thomas H. Inge, Senad Divanovic
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipoc
Externí odkaz:
https://doaj.org/article/d7769e000a41416a858c145b467956f7
Autor:
Alyssa L. Thomas, Pablo C. Alarcon, Senad Divanovic, Claire A. Chougnet, David A. Hildeman, Maria E. Moreno-Fernandez
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Aging and obesity are two conditions characterized by chronic, low-grade inflammation. While both conditions are also associated with dysfunctional immune responses, the shared and distinct underlying mechanisms are just starting to be uncovered. In
Externí odkaz:
https://doaj.org/article/071eff6706d84f6c9f411082e6cb5b5d
Autor:
George S. Deepe, Paul Spearman, Sing Sing Way, Michelle S M A Damen, Rajat Madan, Senad Divanovic, Pablo C Alarcon
Publikováno v:
Mucosal Immunology
Epidemiological evidence establishes obesity as an independent risk factor for increased susceptibility and severity to viral respiratory pneumonias associated with H1N1 influenza and SARS-CoV-2 pandemics. Given the global obesity prevalence, a bette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950e1a0f8269813df14c5f60bb9f1e4c
https://doi.org/10.1038/s41385-021-00404-8
https://doi.org/10.1038/s41385-021-00404-8
Autor:
Sanjay Varikuti, Steve Oghumu, Mohamad Elbaz, Greta Volpedo, Dinesh K. Ahirwar, Pablo C. Alarcon, Rachel H. Sperling, Ellen Moretti, Marissa S. Pioso, Jennifer Kimble, Mohd W. Nasser, Ramesh K. Ganju, Cesar Terrazas, Abhay R. Satoskar
Publikováno v:
OncoImmunology, Vol 6, Iss 11 (2017)
Signal transducer and activator of transcription 1 (STAT1) mediates interferon gamma signaling which activates the expression of various genes related to apoptosis, inflammation, cell cycle and angiogenesis. Several experimental and clinical studies
Externí odkaz:
https://doaj.org/article/b1369d431596477c9ba3fea8ce5c0661
Autor:
David E. Ochayon, Ayad Ali, Leah C. Kottyan, Stephen N. Waggoner, Durga Krishnamurthy, Pablo C. Alarcon, Michael T. Borchers
Publikováno v:
J Leukoc Biol
This study tests the hypothesis that activation of MAPK by physiologically relevant concentrations of IL-33 contributes to enhanced cytokine expression by IL-12 stimulated human NK cells. While IL-33 canonically triggers type 2 cytokine responses, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db0699f3846e4b63a4d0af2fb4af66d
https://doi.org/10.1002/jlb.3a0120-379rr
https://doi.org/10.1002/jlb.3a0120-379rr
Publikováno v:
Obes Rev
Type 2 diabetes (T2D) and obesity are independent risk factors for increased morbidity and mortality associated with influenza and SARS-CoV-2 infection. Skewed cellular metabolism shapes immune cell inflammatory responsiveness and function in obesity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c3f4db7a2f6499d1aaa13df8e9c365
https://europepmc.org/articles/PMC9771603/
https://europepmc.org/articles/PMC9771603/
Autor:
Maria E. Moreno-Fernandez, Michelle S M A Damen, Isaac T.W. Harley, Joan Sanchez-Gurmaches, David A. Relman, Stuart P. Weisberg, Pablo C Alarcon, Matthew J. Flick, Matthias H. Tschöp, Calvin C. Chan, Aurelien Trompette, Rajib Mukherjee, Christopher L. Karp, Randy J. Seeley, Traci E. Stankiewicz, Leah M. Flick, Paul T. Pfluger, Jessica R Doll, Sünje Johanna Pamp, Michael A. Helmrath, Senad Divanovic, Thomas H. Inge, Jarren R Oates, Jessica L. Allen, Rebekah Karns
Publikováno v:
Nature Communications
Chan, C C, Harley, I T W, Pfluger, P T, Trompette, A, Stankiewicz, T E, Allen, J L, Moreno-Fernandez, M E, Damen, M S M A, Oates, J R, Alarcon, P C, Doll, J R, Flick, M J, Flick, L M, Sanchez-Gurmaches, J, Mukherjee, R, Karns, R, Helmrath, M, Inge, T H, Weisberg, S P, Pamp, S J, Relman, D A, Seeley, R J, Tschöp, M H, Karp, C L & Divanovic, S 2021, ' A BAFF/APRIL axis regulates obesogenic diet-driven weight gain ', Nature Communications, vol. 12, no. 1, 2911 . https://doi.org/10.1038/s41467-021-23084-1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nat. Commun. 12:2911 (2021)
Chan, C C, Harley, I T W, Pfluger, P T, Trompette, A, Stankiewicz, T E, Allen, J L, Moreno-Fernandez, M E, Damen, M S M A, Oates, J R, Alarcon, P C, Doll, J R, Flick, M J, Flick, L M, Sanchez-Gurmaches, J, Mukherjee, R, Karns, R, Helmrath, M, Inge, T H, Weisberg, S P, Pamp, S J, Relman, D A, Seeley, R J, Tschöp, M H, Karp, C L & Divanovic, S 2021, ' A BAFF/APRIL axis regulates obesogenic diet-driven weight gain ', Nature Communications, vol. 12, no. 1, 2911 . https://doi.org/10.1038/s41467-021-23084-1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nat. Commun. 12:2911 (2021)
The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role for B cell activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263f2646adf0ada712afeb8ddda964b2
https://doi.org/10.1038/s41467-021-23084-1
https://doi.org/10.1038/s41467-021-23084-1
Autor:
Maria E. Moreno-Fernandez, Matthew T. Weirauch, Jessica R Doll, Rajib Mukherjee, Monica Cappelletti, Michael A. Helmrath, Calvin C. Chan, Thomas H. Inge, Traci E. Stankiewicz, Michelle S M A Damen, Senad Divanovic, Pablo C Alarcon, Xiaoting Chen, Rebekah Karns, Jarren R Oates
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation in disease pathogenesis remain poorly defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae20cadacee51aaaa0ece92bf541e0e9
https://pubmed.ncbi.nlm.nih.gov/32488081
https://pubmed.ncbi.nlm.nih.gov/32488081