Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Pablo Bringas"'
Autor:
Yan Zhou, Pablo Bringas, Christina J. Newcomb, Samuel I. Stupp, Yaping Lei, Malcolm L. Snead, Zhan Huang
Publikováno v:
Biomaterials. 34:3303-3314
Enamel formation involves highly orchestrated intracellular and extracellular events; following development, the tissue is unable to regenerate, making it a challenging target for tissue engineering. We previously demonstrated the ability to trigger
Publikováno v:
Development. 139:1640-1650
The tongue is a muscular organ and plays a crucial role in speech, deglutition and taste. Despite the important physiological functions of the tongue, little is known about the regulatory mechanisms of tongue muscle development. TGFβ family members
Autor:
Joseph Zabner, Ira Kurtz, Pablo Bringas, Michael L. Paine, Charles E. Smith, Antonio Nanci, Sanjeev K. Baniwal, Rodrigo S. Lacruz, Pierre Moffatt, Timothy G. Bromage, Michael J. Welsh, Eugene H. Chang
Publikováno v:
Journal of Cellular Physiology. 227:1776-1785
Transcellular bicarbonate transport is suspected to be an important pathway used by ameloblasts to regulate extracellular pH and support crystal growth during enamel maturation. Proteins that play a role in amelogenesis include members of the ABC tra
Autor:
Michael Glogauer, Rodrigo S. Lacruz, Vesa Kaartinen, Jieun Kim, Malcolm L. Snead, Timothy G. Bromage, Zhan Huang, Pablo Bringas
Publikováno v:
European Journal of Oral Sciences. 119:168-176
The Ras-related C3 botulinum toxin substrate 1 (Rac1) gene encodes a 21-kDa GTP-binding protein belonging to the RAS superfamily. RAS members play important roles in controlling focal adhesion complex formation and cytoskeleton contraction, activitie
Autor:
Pablo Bringas, Susan Smith, Michael L. Paine, Charles E. Smith, Janet Moradian-Oldak, Ping Hu, Miklós Sahin-Tóth, Rodrigo S. Lacruz
Publikováno v:
Journal of Dental Research. 90:1228-1233
Two main proteases cleave enamel extracellular matrix proteins during amelogenesis. Matrix metalloprotease-20 (Mmp20) is the predominant enzyme expressed during the secretory stage, while kallikrein-related peptidase-4 (Klk4) is predominantly express
Autor:
Tina Jaskoll, Pablo Bringas, George Abichaker, Khine Htet, Scott Morita, Michael Melnick, Parish P. Sedghizadeh
Publikováno v:
Cells Tissues Organs. 192:221-239
Of the approximately 8,400 children born each year in the US with cytomegalovirus (CMV)-induced birth defects, more than one third exhibit hypoplasia and hypocalcification of tooth enamel. Our prior studies indicated that CMV severely delayed, but di
Autor:
Jun Han, John L.R. Rubenstein, Jingyuan Li, Pablo Bringas, Richard L. Maas, Xun Xu, Julie Mayo, Yang Chai
Publikováno v:
Development. 136:4225-4233
Cleft palate represents one of the most common congenital birth defects in human. During embryonic development, palatal shelves display oronasal (O-N) and anteroposterior polarity before the onset of fusion, but how the O-N pattern is established and
Publikováno v:
Developmental Biology. 320(1):19-29
TGF-beta superfamily members signal through a heteromeric receptor complex to regulate craniofacial development. TGF-beta type II receptor appears to bind only TGF-beta, whereas TGF-beta type I receptor (ALK5) also binds to ligands in addition to TGF
Autor:
Hui Chen, David Warburton, Pablo Bringas, Jeffrey C. Ma, Cheng Chen, Jeffrey A. Whitsett, Wei Shi, Yuji Mishina, Jianping Sun
Publikováno v:
The American Journal of Pathology. 172:571-582
Bone morphogenetic proteins (BMPs) play important roles in regulating lung development and function although the endogenous regulatory effects of BMP signaling are still controversial. We found that BMP type I receptor Alk3 is expressed predominantly
Publikováno v:
Archives of Oral Biology. 52:1161-1171
Objective The enamel matrix contains amelogenin, leucine-rich amelogenin-polypeptide (LRAP), resulting from alternative splicing of the primary amelogenin-RNA transcript and tyrosine-rich amelogenin-polypeptide (TRAP), a proteolytic product of amelog