4 Combinations of immune checkpoint inhibitors with fractionated radiotherapy or DNA damage response agents leads to improved anti-tumour responses and modulates the tumour immune microenvironment

Autor: Emily Wright, Stewart Brown, Lorraine Mooney, Charlotte Bell, Nick Moore, Theoni Katopodi, Yin Xin Ho, Lyndsey Hanson, Amy Cantrell, Jane Kendrew, Pablo Binder, Tobias Bunday, Paul Farrington, Shannon Sharman

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/04843d98fa6b46d29dbefe7fe5341d13

Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart

Autor: Pablo Binder, Binh Nguyen, Lucy Collins, Min Zi, Wei Liu, Foteini Christou, Xiaojing Luo, Susanne S. Hille, Norbert Frey, Elizabeth J. Cartwright, Jonathan Chernoff, Oliver J. Müller, Kaomei Guan, Xin Wang

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Endoplasmic Reticulum (ER) stress and oxidative stress have been highly implicated in the pathogenesis of cardiac hypertrophy and heart failure (HF). However, the mechanisms involved in the interplay between these processes in the heart are not fully

Externí odkaz: https://doaj.org/article/cf127567c6ca4514b48d2a9c96e5f4e9

Regulation of Long Non-coding RNAs and MicroRNAs in Heart Disease: Insight Into Mechanisms and Therapeutic Approaches

Autor: Lucy Collins, Pablo Binder, Hongshan Chen, Xin Wang

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Cardiovascular disease is the leading cause of mortality worldwide and there is an increasing need to identify new therapeutic targets that could be used to prevent or treat these diseases. Due to recent scientific advances, non-coding RNAs are widel

Externí odkaz: https://doaj.org/article/b0b6e3e09f6f44b989a1e79289e4df65

Regulation of Long Non-coding RNAs and MicroRNAs in Heart Disease: Insight Into Mechanisms and Therapeutic Approaches

Autor: Pablo Binder, Lucy Collins, Xin Wang, Hongshan Chen

Publikováno v: Frontiers in Physiology, Vol 11 (2020)
Collins, L, Binder, P, Chen, H & Wang, X 2020, ' Regulation of Long Non-coding RNAs and MicroRNAs in Heart Disease: Insight Into Mechanisms and Therapeutic Approaches ', Frontiers in Physiology, vol. 11 . https://doi.org/10.3389/fphys.2020.00798
Frontiers in Physiology

Cardiovascular disease is the leading cause of mortality worldwide and there is an increasing need to identify new therapeutic targets that could be used to prevent or treat these diseases. Due to recent scientific advances, non-coding RNAs are widel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce3982e87c3b8d97088d2e7e51bb6c0
https://doi.org/10.3389/fphys.2020.00798

Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

Autor: Oliver J. Müller, Elizabeth J. Cartwright, Lucy Collins, Norbert Frey, Wei Liu, Binh Yen Nguyen, Pablo Binder, Min Zi, Karolina Sekeres, Tayyiba Azam, Xin Wang, Juwei Jiang, Namrita Kaur, Fay Pu, Kaomei Guan, Susanne Hille, Andrea Ruiz-Velasco, Han Xiao

Publikováno v: eLife, Vol 9 (2020)

Myocardial insulin resistance contributes to heart failure in response to pathological stresses, therefore, a therapeutic strategy to maintain cardiac insulin pathways requires further investigation. We demonstrated that insulin receptor substrate 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29554f94d3e128937a936abe09884f0b
https://elifesciences.org/articles/54298