Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pablo B. Martinez de Morentin"'
Autor:
Eleanor J. McKay, Ineke Luijten, Xiong Weng, Pablo B. Martinez de Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G. Kolonin, Lora K. Heisler, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101933- (2024)
Objective: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS
Externí odkaz:
https://doaj.org/article/6169fc3899214b92ba7975f834effd36
Autor:
Stefan Wagner, Daniel I. Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Y.H. Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M. Gribble, Pablo B. Martinez de Morentin, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101665- (2023)
Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e.g
Externí odkaz:
https://doaj.org/article/a7f4d6b4357e4a4d9af68e183e845a6f
Autor:
Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1092-1102 (2017)
Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medicat
Externí odkaz:
https://doaj.org/article/d5d57fc4ef3a41a08e876808e1d9eeec
Autor:
Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 5, Iss 3, Pp 245-252 (2016)
Objective: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration nodes are the brain pro-
Externí odkaz:
https://doaj.org/article/c6e907e380bc4741a86d183bf11641af
Autor:
Pablo B Martinez de Morentin, J Antonio Gonzalez, Yuliia Martynova, Sergiy Sylantyev, Lora K Heisler
The obesity epidemic is principally driven by the consumption of more calories than the body requires. It is therefore essential that the mechanisms underpinning feeding behavior are defined. The brainstem nucleus of the solitary tract (NTS) receives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f12721dfad8530a247807bebbbecdb
https://doi.org/10.1101/2023.05.03.538908
https://doi.org/10.1101/2023.05.03.538908
Autor:
Romain, Gerbier, Delphine, Ndiaye-Lobry, Pablo B, Martinez de Morentin, Erika, Cecon, Lora K, Heisler, Philippe, Delagrange, Florence, Gbahou, Ralf, Jockers
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(1)
Association of G protein-coupled receptors into heterodimeric complexes has been reported for over 50 receptor pairs in vitro but functional in vivo validation remains a challenge. Our recent in vitro studies defined the functional fingerprint of het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb0d534939a648691e3dd46e476adab1
https://pubmed.ncbi.nlm.nih.gov/33156577
https://pubmed.ncbi.nlm.nih.gov/33156577
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ecaa84175ea24c51befe9f2016ac4508
Autor:
Ismael González-García, Cristina Contreras, Ánxela Estévez-Salguero, Francisco Ruíz-Pino, Benoit Colsh, Iván Pensado, Laura Liñares-Pose, Eva Rial-Pensado, Pablo B. Martínez de Morentin, Johan Fernø, Carlos Diéguez, Rubén Nogueiras, Hervé Le Stunff, Christophe Magnan, Manuel Tena-Sempere, Miguel López
Publikováno v:
Cell Reports, Vol 25, Iss 2, Pp 413-423.e5 (2018)
Summary: Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The anorectic effect of E2 i
Externí odkaz:
https://doaj.org/article/c1db47d61cee4185bf03bacbe6c6c71a