Zobrazeno 1 - 10 of 108 pro vyhledávání: '"Pablo Arnoletti"'
1
Akademický článek
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells
Autor: Sarah B. Gitto, Jordan M. Beardsley, Sai Preethi Nakkina, Jeremiah L. Oyer, Kathryn A. Cline, Sally A. Litherland, Alicja J. Copik, Amr S. Khaled, Na’im Fanaian, J. Pablo Arnoletti, Deborah A. Altomare
Publikováno v: Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background While inflammation is associated with pancreatic cancer, the underlying mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote or inhibit tumor growth, although the specific role in pancreatic
Externí odkaz: https://doaj.org/article/182a76e644af4cc9a41cfff458d20fb4
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2
Akademický článek
Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation
Autor: Juan Pablo Arnoletti, Joseph Reza, Armando Rosales, Alberto Monreal, Na’im Fanaian, Suzanne Whisner, Milan Srivastava, Julia Rivera-Otero, Gongxin Yu, Otto Phanstiel IV, Deborah A. Altomare, Quang Tran, Sally A. Litherland
Publikováno v: PLoS ONE, Vol 17, Iss 3 (2022)
The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of metastasis. Turbulent flow in the portal circulation promotes retention of PDAC shed circul
Externí odkaz: https://doaj.org/article/9635aceb322141dd801e0f80dcad7104
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3
Akademický článek
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
Autor: Kathleen Smith, Elnaz Karimian Azari, Traci E. LaMoia, Tania Hussain, Veronika Vargova, Katalin Karolyi, Paula P. Veldhuis, Juan Pablo Arnoletti, Sebastian G. de la Fuente, Richard E. Pratley, Timothy F. Osborne, George A. Kyriazis
Publikováno v: Molecular Metabolism, Vol 17, Iss , Pp 98-111 (2018)
Objective: Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown. Methods: Using T1R
Externí odkaz: https://doaj.org/article/b5f0a7377256460193c5a2ac2e6f68cf
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9
Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function
Autor: Aiste Dobrovolskaite, Holly Moots, Mukund P. Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M. Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel
Publikováno v: Journal of medicinal chemistry. 65(22)
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5048172ae7721fd307b0c1dc01dcba9b
https://pubmed.ncbi.nlm.nih.gov/36382923
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