Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pablo Alcón"'
Autor:
Apaza, Juan Pablo Alcon
We study the removability of a singular set for elliptic equations involving weight functions and variable exponents. We consider the case where the singular set satisfies conditions related to some generalization of upper Minkowski content or a net
Externí odkaz:
http://arxiv.org/abs/2205.09101
Autor:
Apaza, Juan Pablo Alcon
We study the removability of a singular set in the boundary of Neumann problem for elliptic equations with variable exponent. We consider the case where the singular set is compact, and give sufficient conditions for removability of this singularity
Externí odkaz:
http://arxiv.org/abs/2203.13439
Autor:
Emny Rochell Bobadilla-Romero, Miriam Artés-Artés, Víctor Javier García-Porcel, Pablo Alcón-Cerro, Pablo Luís Guzmán-Martínez-Valls, José David Jiménez-Parra
Publikováno v:
Revista Mexicana de Urología. 82:1-9
Descripción del caso clínico: Varón de 67 años con antecedente de cistectomía radical por tumor vesical músculo invasivo, presenta un cuadro agudo de edema y eritema periorbitario izquierdo acompañado de dolor y disminución de la motilidad oc
Autor:
Tamara Sijacki, Pablo Alcón, Zhuo A. Chen, Stephen H. McLaughlin, Shabih Shakeel, Juri Rappsilber, Lori A. Passmore
Publikováno v:
Nat Struct Mol Biol
Sijacki, T, Alcón, P, Chen, Z A, Mclaughlin, S H, Shakeel, S, Rappsilber, J & Passmore, L A 2022, ' The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination ', Nature Structural & Molecular Biology, vol. 29, no. 9, pp. 881-890 . https://doi.org/10.1038/s41594-022-00820-9
Sijacki, T, Alcón, P, Chen, Z A, Mclaughlin, S H, Shakeel, S, Rappsilber, J & Passmore, L A 2022, ' The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination ', Nature Structural & Molecular Biology, vol. 29, no. 9, pp. 881-890 . https://doi.org/10.1038/s41594-022-00820-9
DNA interstrand crosslinks are tumor-inducing lesions that block DNA replication and transcription. When crosslinks are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2-FANCI cl
Autor:
José A. Manso, Tamara Marcos, Virginia Ruiz-Martín, Javier Casas, Pablo Alcón, Mariano Sánchez Crespo, Yolanda Bayón, José M. de Pereda, Andrés Alonso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds to LYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572747db1f1eb632d28756392d5bc6ed
http://hdl.handle.net/10261/282511
http://hdl.handle.net/10261/282511
Autor:
Shabih Shakeel, Christopher J. Russo, Gianluca Degliesposti, Pablo Alcón, Eeson Rajendra, J.M. Skehel, Ketan J. Patel, Sarah L. Maslen, Carol V. Robinson, Chris H. Hill, Dror S. Chorev, Francis J. O’Reilly, Juri Rappsilber, Shaoda He, Sjors H.W. Scheres, Lori A. Passmore
Publikováno v:
Shakeel, S, Rajendral, E, Alcón, P, O’Reilly, F J, Chorev, D S, Maslen, S, Degliesposti, G, Russo, C J, He, S, Hill, C H, Skehel, J M, Scheres, S H W, Patel, K J, Rappsilber, J, Robinson, C V & Passmore, L A 2019, ' Structure of the fanconi anaemia monoubiquitin ligase complex ', Nature, vol. 575, pp. 234-237 . https://doi.org/10.1038/s41586-019-1703-4
Nature
Nature
The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC
Publikováno v:
Alcón, P, Shakeel, S, Chen, Z A, Rappsilber, J, Patel, K J & Passmore, L A 2020, ' FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair ', Nature Structural and Molecular Biology, vol. 27, no. 3, pp. 240-248 . https://doi.org/10.1038/s41594-020-0380-1
Nature structural & molecular biology
Nature structural & molecular biology
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dee59bf22e62e4f4da816000c77dee
https://www.pure.ed.ac.uk/ws/files/157669496/PMID32066963_AAM_Rappsilber.pdf
https://www.pure.ed.ac.uk/ws/files/157669496/PMID32066963_AAM_Rappsilber.pdf
Publikováno v:
Nature Structural & Molecular Biology. 24:882-892
CRISPR-Cas is a bacterial defense system against phage infection and nucleic acid invasion. Class 2 type II CRISPR-Cas9 has also been widely used for genome engineering. Here, we review novel insights into the CRISPR class 2 type V enzymes, specifica
Publikováno v:
Nature. 546:559-563
Cpf1 is a single RNA-guided endonuclease of class 2 type V CRISPR-Cas system, emerging as a powerful genome editing tool 1,2. To provide insight into its DNA targeting mechanism, we have determined the crystal structure of Francisella novicida Cpf1 (
Autor:
Matias E. Moses, Pablo Alcón, Bijoya Paul, Simon Jensen, Guillermo Montoya, Stefano Stella, Pablo Mesa, Nikos S. Hatzakis, Johannes Thomsen
Publikováno v:
Biophysical Journal. 118:223a-224a