Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Paavo Honkakoski"'
Autor:
William A. Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D. Guy, Manal F. Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Hepatology Communications, Vol 8, Iss 3 (2024)
Background:. NAFLD is highly prevalent with limited treatment options. Bile acids (BAs) increase in the systemic circulation and liver during NAFLD progression. Changes in plasma membrane localization and zonal distribution of BA transporters can inf
Externí odkaz:
https://doaj.org/article/aac573e3c0734319af4532863a1f9a55
Autor:
Chitra Saran, Dong Fu, Henry Ho, Abigail Klein, John K. Fallon, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Hepatic cell lines serve as economical and reproducible alternatives for primary human hepatocytes. However, the utility of hepatic cell lines to examine bile acid homeostasis and cholestatic toxicity is limited due to abnormal expression an
Externí odkaz:
https://doaj.org/article/2e928e8ce9f046e3be3c75900b5eddad
Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV). Regulation of human NTCP re
Externí odkaz:
https://doaj.org/article/b61567257f57433bbe976e0248d56cad
Autor:
Mery Giantin, Minna Rahnasto-Rilla, Roberta Tolosi, Lorena Lucatello, Marianna Pauletto, Giorgia Guerra, Francesca Pezzato, Rosa M. Lopparelli, Roberta Merlanti, Paolo Carnier, Francesca Capolongo, Paavo Honkakoski, Mauro Dacasto
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Cytochrome P450 3A is the most important CYP subfamily in humans, and CYP3A4/CYP3A5 genetic variants contribute to inter-individual variability in drug metabolism. However, no information is available for bovine CYP3A (bCYP3A). Here we descr
Externí odkaz:
https://doaj.org/article/c25ec162a21642f68798b8d5ca6a8b2b
Autor:
Henna Martiskainen, Kaisa M. A. Paldanius, Teemu Natunen, Mari Takalo, Mikael Marttinen, Stina Leskelä, Nadine Huber, Petra Mäkinen, Enni Bertling, Hiramani Dhungana, Mikko Huuskonen, Paavo Honkakoski, Pirta Hotulainen, Kirsi Rilla, Jari Koistinaho, Hilkka Soininen, Tarja Malm, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer’s
Externí odkaz:
https://doaj.org/article/6ffdfce30aa34abe808f0d76198110f4
Autor:
Mery Giantin, Jenni Küblbeck, Vanessa Zancanella, Viktoria Prantner, Fabiana Sansonetti, Axel Schoeniger, Roberta Tolosi, Giorgia Guerra, Silvia Da Ros, Mauro Dacasto, Paavo Honkakoski
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214338 (2019)
The regulation of cytochrome P450 3A (CYP3A) enzymes is established in humans, but molecular mechanisms of its basal and xenobiotic-mediated regulation in cattle are still unknown. Here, ~10 kbp of the bovine CYP3A28 gene promoter were cloned and seq
Externí odkaz:
https://doaj.org/article/10a856486a344243b0db48ce3b235c05
Publikováno v:
Cells, Vol 9, Iss 10, p 2306 (2020)
During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules.
Externí odkaz:
https://doaj.org/article/0b49b7976100414f932f6bd3cac927da
Autor:
Jenni Küblbeck, Taina Vuorio, Jonna Niskanen, Vittorio Fortino, Albert Braeuning, Khaled Abass, Arja Rautio, Jukka Hakkola, Paavo Honkakoski, Anna-Liisa Levonen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 3021 (2020)
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been
Externí odkaz:
https://doaj.org/article/ff26a03b74de4fce88dd9c25a9c96461
Autor:
Katayun Bahrami, Juulia Järvinen, Tuomo Laitinen, Mika Reinisalo, Paavo Honkakoski, Antti Poso, Kristiina M. Huttunen, Jarkko Rautio
Publikováno v:
Molecular Pharmaceutics. 20:206-218
L-type amino acid transporter 1 (LAT1) transfers essential amino acids across cell membranes. Owing to its predominant expression in the blood-brain barrier and tumor cells, LAT1 has been exploited for drug delivery and targeting to the central nervo
Autor:
Anam Hammid, John K. Fallon, Toni Lassila, Paula Vieiro, Anusha Balla, Francisco Gonzalez, Arto Urtti, Philip C. Smith, Ari Tolonen, Paavo Honkakoski
Publikováno v:
Drug Metabolism and Disposition. 50:1483-1492
As a multitissue organ, the eye possesses unique anatomy and physiology, including differential expression of drug-metabolizing enzymes. Several hydrolytic enzymes that play a major role in drug metabolism and bioactivation of prodrugs have been dete