Zobrazeno 1 - 10
of 382
pro vyhledávání: '"Pärt Peterson"'
Autor:
Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have exp
Externí odkaz:
https://doaj.org/article/e691596e5a1945598aa5b7e47fe61d36
Autor:
Thea Sjøgren, Shahinul Islam, Igor Filippov, Adrianna Jebrzycka, André Sulen, Lars E. Breivik, Alexander Hellesen, Anders P. Jørgensen, Kari Lima, Liina Tserel, Kai Kisand, Pärt Peterson, Annamari Ranki, Eystein S. Husebye, Bergithe E. Oftedal, Anette S.B. Wolff
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109610- (2024)
Summary: Immune tolerance fails in autoimmune polyendocrine syndrome type 1 (APS-1) because of AIRE mutations. We have used single cell transcriptomics to characterize regulatory T cells (Tregs) sorted directly from blood and from in vitro expanded T
Externí odkaz:
https://doaj.org/article/d561157f8af44cf283e99d4081208415
Autor:
Lehte Türk, Igor Filippov, Christian Arnold, Judith Zaugg, Liina Tserel, Kai Kisand, Pärt Peterson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As humans age, their memory T cell compartment expands due to the lifelong exposure to antigens. This expansion is characterized by terminally differentiated CD8+ T cells (Temra), which possess NK cell-like phenotype and are associated with chronic i
Externí odkaz:
https://doaj.org/article/7c983ae33dc644d99c2f03c56307f8ec
Autor:
Antoine Freuchet, Apolline Salama, Séverine Bézie, Laurent Tesson, Séverine Rémy, Romain Humeau, Hadrien Règue, Céline Sérazin, Léa Flippe, Pärt Peterson, Nadège Vimond, Claire Usal, Séverine Ménoret, Jean‐Marie Heslan, Franck Duteille, Frédéric Blanchard, Magali Giral, Marco Colonna, Ignacio Anegon, Carole Guillonneau
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Background Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL‐34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its
Externí odkaz:
https://doaj.org/article/66e3ea0bfcc54419864f02858ee50ceb
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 952 (2023)
mRNA-based therapeutics are presently one of the nucleic acid-based therapeutics with a high potential for extraordinary success as preventive vaccines. Current applications with mRNA therapeutics rely on lipid nanoparticle (LNP) mediated delivery of
Externí odkaz:
https://doaj.org/article/288cfc8152c14aedae77b5a6ca3bd054
Autor:
Marine Besnard, Céline Sérazin, Jason Ossart, Anne Moreau, Nadège Vimond, Léa Flippe, Hanna Sein, Grace A. Smith, Stefania Pittaluga, Elise M.N. Ferré, Claire Usal, Ignacio Anegon, Annamari Ranki, Michail S. Lionakis, Pärt Peterson, Carole Guillonneau
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Targeted monoclonal antibody (mAb) therapies show great promise for the treatment of transplant rejection and autoimmune diseases by inducing more specific immunomodulatory effects than broadly immunosuppressive drugs routinely used. We recently desc
Externí odkaz:
https://doaj.org/article/3354f3a8b337479b98648db65c0555cf
Autor:
Liis Haljasmägi, Ahto Salumets, Anna Pauliina Rumm, Meeri Jürgenson, Ekaterina Krassohhina, Anu Remm, Hanna Sein, Lauri Kareinen, Olli Vapalahti, Tarja Sironen, Hedi Peterson, Lili Milani, Anu Tamm, Adrian Hayday, Kai Kisand, Pärt Peterson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring inte
Externí odkaz:
https://doaj.org/article/122d14a3063c481cb0cc3d33b02d79ac
Autor:
Liina Tserel, Piia Jõgi, Paul Naaber, Julia Maslovskaja, Annika Häling, Ahto Salumets, Eva Zusinaite, Hiie Soeorg, Freddy Lättekivi, Diana Ingerainen, Mari Soots, Karolin Toompere, Katrin Kaarna, Kai Kisand, Irja Lutsar, Pärt Peterson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The clinical features of SARS-CoV-2 infection range from asymptomatic to severe disease with life-threatening complications. Understanding the persistence of immune responses in asymptomatic individuals merit special attention because of their import
Externí odkaz:
https://doaj.org/article/16d58d8a765443ca94de79c1eecf2447
Autor:
Martti Laan, Ahto Salumets, Annabel Klein, Kerli Reintamm, Rudolf Bichele, Hedi Peterson, Pärt Peterson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While there is convincing evidence on the role of Aire-positive medullary thymic epithelial cells (mTEC) in the induction of central tolerance, the nature and function of post-Aire mTECs and Hassall’s corpuscles have remained enigmatic. Here we sum
Externí odkaz:
https://doaj.org/article/d5c2e9c9aaa443a390376ab6ef20e726
Autor:
Epp Kaleviste, Malte Rühlemann, Jaanika Kärner, Liis Haljasmägi, Liina Tserel, Elin Org, Katarina Trebušak Podkrajšek, Tadej Battelino, Corinna Bang, Andre Franke, Pärt Peterson, Kai Kisand
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by recessive mutations in the AIRE gene. The hallmark of the disease is the production of highly neutralizing autoantibodies against type I interferons and IL-22. Consi
Externí odkaz:
https://doaj.org/article/7d0543e10bfe4cca82d92a0830a8d842